INT14571

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Context Info
Confidence 0.23
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 2.44
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
plasma 2
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 5 100.00 Very High Very High Very High
Opioid 1 89.68 High High
opiate 1 85.24 High High
tolerance 6 84.16 Quite High
Endogenous opioid 1 55.84 Quite High
Potency 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
potassium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polycystic Ovary Syndrome 9 98.88 Very High Very High Very High
Hyperinsulinism 12 98.08 Very High Very High Very High
Diabetes Mellitus 129 96.76 Very High Very High Very High
Impaired Glucose Tolerance 8 85.52 High High
Obesity 5 80.16 Quite High
Insulin Resistance 2 79.60 Quite High
Syndrome 1 63.72 Quite High
Stress 4 55.32 Quite High
Targeted Disruption 2 18.80 Low Low
Birth Weight 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These mutations affect amino acids involved in insulin receptor binding (B24-Phe, B25-Phe and A3-Val) and as a consequence the mutant insulins have reduced insulin receptor affinity and biological activity.
Regulation (involved) of insulin Binding (binding) of
1) Confidence 0.23 Published 2010 Journal Rev Endocr Metab Disord Section Body Doc Link PMC2974937 Disease Relevance 1.35 Pain Relevance 0.08
Effect of naloxone on plasma insulin, insulin-like growth factor I, and its binding protein 1 in patients with polycystic ovarian disease.
Regulation (Effect) of insulin Binding (binding) of in plasma associated with narcan and polycystic ovary syndrome
2) Confidence 0.06 Published 1990 Journal Fertil. Steril. Section Title Doc Link 1697813 Disease Relevance 1.09 Pain Relevance 0.46

General Comments

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