INT14572

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Context Info
Confidence 0.48
First Reported 1983
Last Reported 2011
Negated 7
Speculated 8
Reported most in Body
Documents 205
Total Number 217
Disease Relevance 175.43
Pain Relevance 13.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
plasma 12
blood 8
heart 4
body 4
coronary artery 3
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 502 100.00 Very High Very High Very High
cytokine 238 100.00 Very High Very High Very High
Somatostatin 27 100.00 Very High Very High Very High
Enkephalin 10 100.00 Very High Very High Very High
Catecholamine 8 100.00 Very High Very High Very High
Inflammatory marker 28 99.80 Very High Very High Very High
narcan 11 99.78 Very High Very High Very High
adenocard 42 99.76 Very High Very High Very High
agonist 164 99.64 Very High Very High Very High
Inflammation 518 99.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 8240 100.00 Very High Very High Very High
Insulin Resistance 1949 100.00 Very High Very High Very High
Obesity 1878 100.00 Very High Very High Very High
Metabolic Syndrome 811 100.00 Very High Very High Very High
Impaired Glucose Tolerance 553 100.00 Very High Very High Very High
Hyperglycemia 536 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 445 100.00 Very High Very High Very High
Cancer 431 100.00 Very High Very High Very High
Hyperinsulinism 326 100.00 Very High Very High Very High
Aging 210 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insulin secretion decreases with increased hyperglycemia (g1ucotoxicity), and diabetic subjects have increased levels of proinsulin, which is recognized by some (but not all) insulin assays.21 Insulin is reported to have considerable cross-reactivity with proinsulin.19,20,22 While the euglycemic clamp test is widely regarded as the 'gold standard' for sensitivity measurement, it remains a laboratory procedure, because it requires sophisticated equipment, highly trained personnel, and is a lengthy procedure.
proinsulin Binding (recognized) of associated with hyperglycemia and diabetes mellitus
1) Confidence 0.48 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815832 Disease Relevance 0.88 Pain Relevance 0.08
First, the antibodies may bind to the insulin blocking its action with resulting hyperglycemia.63,64 Secondly, the insulin may then be released from the antibody complex, with inappropriate insulin action (discordant with carbohydrate intake) and delayed hypoglycemia.65,66 In rare cases, true insulin allergies may develop.62
insulin Binding (bind) of associated with hypoglycemia, hyperglycemia and hypersensitivity
2) Confidence 0.48 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835554 Disease Relevance 0.58 Pain Relevance 0.04
Another hypothesis is that insulin interacts with specific or non-specific binding sites on the scleral structures.
insulin Binding (interacts) of
3) Confidence 0.48 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2633461 Disease Relevance 0.12 Pain Relevance 0.08
Affinity of insulin for the scleral tissue
insulin Binding (Affinity) of
4) Confidence 0.48 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2633461 Disease Relevance 0 Pain Relevance 0.19
Regardless of the nature of this interaction, we have estimated that the affinity of insulin for the sclera was the same for porcine and human tissues.
insulin Binding (affinity) of in sclera
5) Confidence 0.48 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2633461 Disease Relevance 0.05 Pain Relevance 0.07
These intermediates exhibited less immunoprecipitability with antiinsulin antibody and receptor binding with liver membrane preparations than intact insulin.
insulin Binding (binding) of in liver
6) Confidence 0.47 Published 1985 Journal Endocrinology Section Abstract Doc Link 3882399 Disease Relevance 0 Pain Relevance 0.15
Insulin resistance syndrom (IR) is often associated with the syndrome of microvascular angina pectoris (MVAP) or with coronary artery disease (CAD).
Insulin Binding (associated) of in coronary artery associated with angina, coronary artery disease, syndrome, insulin resistance and microvascular angina
7) Confidence 0.47 Published 2000 Journal Vnitr Lek Section Abstract Doc Link 11227172 Disease Relevance 0.85 Pain Relevance 0.41
Insulin binds to its receptor on the cell membrane facilitating the delivery of glucose across the membrane by enhancing the expression of GLUT transporters (Stephens and Pilch 1995).
Insulin Binding (binds) of
8) Confidence 0.45 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994046 Disease Relevance 1.73 Pain Relevance 0
Another stated: “For me, what I don’t like about insulin is the inconvenience.
insulin Binding (about) of
9) Confidence 0.37 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2915552 Disease Relevance 0 Pain Relevance 0
For example, insulin was complexed with cyclodextrins (CD) in order to improve its solubility and stability in the form of a dry powder, after encapsulation into poly (D,L-lactic-co-glycolic acid) (PLGA) microspheres58.
insulin Binding (complexed) of in poly
10) Confidence 0.37 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792528 Disease Relevance 0 Pain Relevance 0
PAEE was significantly and inversely associated with fasting insulin independently of sex, age and body fat.
insulin Binding (associated) of in fat
11) Confidence 0.37 Published 2008 Journal Diabetologia Section Body Doc Link PMC2491413 Disease Relevance 0.09 Pain Relevance 0
A variety of approaches have been proposed to qualitatively and quantitatively describe insulin sensitivity;12,13 for example, fasting or postprandial insulin and C-peptide, the insulin tolerance test (ITT),14,15 the frequently sampled intravenous glucose tolerance test (FSIVGTT),16,17 and the euglycemic clamp test.18 Of these approaches, insulin concentration, especially fasting insulin concentration, although commonly used as a surrogate for insulin resistance,19,20 may not be an optimum choice as a surrogate for insulin resistance in type 2 diabetic patients.
insulin Binding (surrogate) of associated with diabetes mellitus, tolerance, insulin resistance and impaired glucose tolerance
12) Confidence 0.37 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815832 Disease Relevance 1.04 Pain Relevance 0.10
Insulin secretion decreases with increased hyperglycemia (g1ucotoxicity), and diabetic subjects have increased levels of proinsulin, which is recognized by some (but not all) insulin assays.21 Insulin is reported to have considerable cross-reactivity with proinsulin.19,20,22 While the euglycemic clamp test is widely regarded as the 'gold standard' for sensitivity measurement, it remains a laboratory procedure, because it requires sophisticated equipment, highly trained personnel, and is a lengthy procedure.
Insulin Binding (assays.21) of associated with hyperglycemia and diabetes mellitus
13) Confidence 0.37 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815832 Disease Relevance 0.86 Pain Relevance 0.08
Insulin secretion decreases with increased hyperglycemia (g1ucotoxicity), and diabetic subjects have increased levels of proinsulin, which is recognized by some (but not all) insulin assays.21 Insulin is reported to have considerable cross-reactivity with proinsulin.19,20,22 While the euglycemic clamp test is widely regarded as the 'gold standard' for sensitivity measurement, it remains a laboratory procedure, because it requires sophisticated equipment, highly trained personnel, and is a lengthy procedure.
insulin Binding (assays.21) of associated with hyperglycemia and diabetes mellitus
14) Confidence 0.37 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815832 Disease Relevance 0.86 Pain Relevance 0.08
Biphasic insulin aspart in type 1 diabetes
Biphasic insulin Binding (aspart) of associated with diabetes mellitus
15) Confidence 0.37 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350128 Disease Relevance 0.77 Pain Relevance 0
Biphasic insulin aspart in type 2 diabetes
Biphasic insulin Binding (aspart) of associated with diabetes mellitus
16) Confidence 0.37 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350128 Disease Relevance 0.41 Pain Relevance 0
In recognizing the barriers to achieving current glycemic targets, the Global Partnership for Effective Diabetes Management now recommends that combination therapy or insulin should be initiated immediately for all patients with HbA1c ?
insulin Binding (initiated) of associated with diabetes mellitus
17) Confidence 0.37 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994047 Disease Relevance 0.88 Pain Relevance 0.06
Insulin dosage
Insulin Binding (dosage) of
18) Confidence 0.37 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.30 Pain Relevance 0
A consistent and important clinical finding in all of these large trials was that insulin glargine resulted in a lower incidence of nocturnal hypoglycemia than that associated with NPH insulin.
NPH insulin Binding (associated) of associated with hypoglycemia
19) Confidence 0.37 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.30 Pain Relevance 0
NPH insulin also has an early peak at around 4 to 6 hours following subcutaneous injection and this can be associated with hypoglycemia, a limiting and potentially dangerous adverse effect (Home et al. 2005).
NPH insulin Binding (associated) of associated with hypoglycemia
20) Confidence 0.37 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.36 Pain Relevance 0

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