INT145756

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.74
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 23
Total Number 36
Disease Relevance 20.77
Pain Relevance 5.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tlr2) cytoplasm (Tlr2)
Anatomy Link Frequency
monocytes 4
whiskers 3
microglia 3
dendritic cells 2
astrocytes 2
Tlr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 35 98.94 Very High Very High Very High
Inflammation 402 97.76 Very High Very High Very High
Hyperalgesia 10 97.60 Very High Very High Very High
cytokine 292 97.24 Very High Very High Very High
noradrenaline 12 96.76 Very High Very High Very High
B1 receptor 97 96.16 Very High Very High Very High
Catecholamine 12 95.88 Very High Very High Very High
Spinal cord 29 93.52 High High
Inflammatory mediators 20 92.36 High High
antagonist 26 91.40 High High
Disease Link Frequency Relevance Heat
Stress 300 99.36 Very High Very High Very High
Nociception 8 99.04 Very High Very High Very High
Infection 640 98.92 Very High Very High Very High
Dehydration 6 98.68 Very High Very High Very High
Cold Sores 854 97.84 Very High Very High Very High
INFLAMMATION 496 97.76 Very High Very High Very High
Hyperalgesia 21 97.60 Very High Very High Very High
Disease 164 97.48 Very High Very High Very High
Sprains And Strains 730 97.24 Very High Very High Very High
Pathologic Constriction 5 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the whiskers area of DA rats the increase of cell surface Tlr2 expression was delayed starting from 2 dpi, while in PVG rats an increase was evident from 1 dpi.
Gene_expression (expression) of Tlr2 in whiskers
1) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.31 Pain Relevance 0.05
Notably, the levels of Tlr2 and -9 were higher in the resistant PVG rats (Figure 5A and 5D).
Gene_expression (levels) of Tlr2
2) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.60 Pain Relevance 0.09
In the resistant PVG rat expression of Tlr2 and -9 was significantly higher in the whiskers area at 1 and 2 dpi, the same time point at which the highest number of phagocytic cells was detected.
Gene_expression (expression) of Tlr2 in whiskers
3) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.89 Pain Relevance 0.17
In DA rats increased expression of Tlr2 was observed in the trigeminal ganglia at 2 dpi and in the brain stem at 4 dpi, while the expression in PVG rats was unchanged.
Gene_expression (expression) of Tlr2 in brain stem
4) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.35 Pain Relevance 0.04
In the central nervous system microglia, astrocytes, oligodendrocytes and neurons express TLR2, -3, -4 and -9 [11], [12].
Gene_expression (express) of TLR2 in astrocytes associated with central nervous system
5) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.51 Pain Relevance 0.05
Interestingly, DA rats presented lower expression of Tlr2 in the whiskers area at 1–2 dpi (Figure 5A) and Tlr9 from 2 dpi (Figure 5D), correlating with a lower recruitment of phagocyting cells in this compartment (Figure 4C and 4M).
Gene_expression (expression) of Tlr2 in whiskers
6) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.62 Pain Relevance 0.03
Since Tlr2 is found on the surface of macrophages and dendritic cells, it is likely that the increase in expression reflects a more rapid and vigorous recruitment of phagocyting cells in the resistant PVG strain.
Gene_expression (found) of Tlr2 in macrophages associated with sprains and strains
7) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.79 Pain Relevance 0.16
Few studies have investigated the impact of chronic stress on TLR expression and function, however of those that have done so, repeated social defeat stress has been shown to increase the expression of TLR2 and TLR4 [19] and increase TLR-mediated release of pro-inflammatory cytokines from splenic monocytes and dendritic cells [20].
Gene_expression (expression) of TLR2 in dendritic cells associated with stress, inflammation and cytokine
8) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785428 Disease Relevance 0.98 Pain Relevance 0.31
[56] or H. influenzae [57] to enhance the expression of TLR2 in human colonic or alveolar epithelial cells.
Gene_expression (expression) of TLR2 in epithelial cells
9) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785428 Disease Relevance 1.16 Pain Relevance 0.15
Notably, expression of Tlr2, Tlr4, Myd88 and Tnf?
Gene_expression (expression) of Tlr2
10) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 1.05 Pain Relevance 0.06
Our data demonstrate the novel observation that genetically encoded properties of the host nerve and perineurial cells, recruitment of phagocyting cells together with the low expression of Tlr2 and -9 in the periphery define the susceptibility to HSV-1 entry into the nervous system.



Gene_expression (expression) of Tlr2 in nerve associated with cold sores
11) Confidence 0.57 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2929186 Disease Relevance 0.74 Pain Relevance 0
Our results determine a host dependent difference of Tlr2 and -9 expression with a subsequent difference in Tnf?
Gene_expression (expression) of Tlr2
12) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 1.33 Pain Relevance 0.18
Furthermore, 2 hours after PCI a significant decrease in TLR2 and TLR4 response (p<0.001) and TLR2 and TLR4 expression (p = 0.001 and p = 0.068, respectively) was seen.
Gene_expression (expression) of TLR2
13) Confidence 0.54 Published 2008 Journal Heart Section Body Doc Link 17686802 Disease Relevance 0.12 Pain Relevance 0
TLR2 and TLR4 expression on, and tumour necrosis factor alpha (TNFalpha) levels in, monocytes were measured with flow cytometry.
Gene_expression (expression) of TLR2 in monocytes
14) Confidence 0.54 Published 2008 Journal Heart Section Body Doc Link 17686802 Disease Relevance 0.17 Pain Relevance 0
Infection with the obligate parasite T. gondii has been shown to increase expression of certain TLRs (TLR2, 4, 9 & 11 (murine)) while cold water stress following infection seems to decrease the expression of the same TLRs [58].
Gene_expression (expression) of TLR2 associated with dehydration and infection
15) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785428 Disease Relevance 1.08 Pain Relevance 0.31
No significant differences in expression were found for TLR2 (Figure 3a & 3b) while as before, TLR6 could not be detected in all samples in both strains.
Gene_expression (found) of TLR2 associated with sprains and strains
16) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785428 Disease Relevance 0.82 Pain Relevance 0.09
OBJECTIVE: To examine the effect of a percutaneous coronary intervention (PCI) on TLR2 and TLR4 response and expression.
Gene_expression (expression) of TLR2
17) Confidence 0.47 Published 2008 Journal Heart Section Body Doc Link 17686802 Disease Relevance 0.19 Pain Relevance 0
No significant differences were noted for TLR2, 7, 9 & 10 while TLR6 could not be detected in all samples in both rat strains.


Neg (No) Gene_expression (noted) of TLR2 associated with sprains and strains
18) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785428 Disease Relevance 0.64 Pain Relevance 0.04
Systemic TLR2 and TLR4 response and expression decrease after PCI.
Gene_expression (expression) of TLR2
19) Confidence 0.42 Published 2008 Journal Heart Section Body Doc Link 17686802 Disease Relevance 0.05 Pain Relevance 0
Monocyte toll-like receptor 2 and 4 responses and expression following percutaneous coronary intervention: association with lesion stenosis and fractional flow reserve.
Gene_expression (expression) of toll-like receptor 2 in Monocyte associated with pathologic constriction
20) Confidence 0.41 Published 2008 Journal Heart Section Title Doc Link 17686802 Disease Relevance 0.10 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox