INT145758

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 0.94
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tlr2) cytoplasm (Tlr2)
Anatomy Link Frequency
fibroblasts 1
Tlr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 63 76.28 Quite High
Inflammation 69 72.16 Quite High
Inflammatory mediators 3 27.88 Quite Low
Inflammatory response 27 16.96 Low Low
ketamine 6 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
Thoracotomy 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 3 98.40 Very High Very High Very High
Disease 6 93.08 High High
Arterial Occlusive Diseases 3 92.72 High High
INFLAMMATION 96 72.16 Quite High
Injury 3 68.96 Quite High
Pressure And Volume Under Development 6 58.84 Quite High
Adult Respiratory Distress Syndrome 6 57.88 Quite High
Targeted Disruption 6 53.04 Quite High
Lung Injury 39 50.00 Quite Low
Pathologic Constriction 3 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Systemic TLR2 and TLR4 response and expression decrease after PCI.
Regulation (response) of TLR2
1) Confidence 0.43 Published 2008 Journal Heart Section Body Doc Link 17686802 Disease Relevance 0.05 Pain Relevance 0
OBJECTIVE: To examine the effect of a percutaneous coronary intervention (PCI) on TLR2 and TLR4 response and expression.
Spec (examine) Regulation (effect) of TLR2
2) Confidence 0.31 Published 2008 Journal Heart Section Body Doc Link 17686802 Disease Relevance 0.19 Pain Relevance 0
We used a cell line of human lung fibroblasts IMR-90 (American Type Culture Collection), as positive control for TLR2 protein levels.
Regulation (control) of TLR2 in fibroblasts
3) Confidence 0.26 Published 2010 Journal Respir Res Section Body Doc Link PMC2841148 Disease Relevance 0 Pain Relevance 0
We observed that high VT MV for 4 h induced up-regulation of TLR4 (and not TLR2) protein levels, a receptor related to LPS signal transduction and the classical NF-?
Regulation (regulation) of TLR2
4) Confidence 0.19 Published 2010 Journal Respir Res Section Body Doc Link PMC2841148 Disease Relevance 0.32 Pain Relevance 0.12
B and up-regulated TLR4 but not TLR2
Neg (not) Regulation (regulated) of TLR2
5) Confidence 0.19 Published 2010 Journal Respir Res Section Body Doc Link PMC2841148 Disease Relevance 0.26 Pain Relevance 0.10
Furthermore, 2 hours after PCI a significant decrease in TLR2 and TLR4 response (p<0.001) and TLR2 and TLR4 expression (p = 0.001 and p = 0.068, respectively) was seen.
Regulation (response) of TLR2
6) Confidence 0.08 Published 2008 Journal Heart Section Body Doc Link 17686802 Disease Relevance 0.12 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox