INT145760

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.59
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tlr2) cytoplasm (Tlr2)
Anatomy Link Frequency
macrophages 1
blood 1
Monocyte 1
Tlr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 83 99.92 Very High Very High Very High
cytokine 45 99.08 Very High Very High Very High
Inflammatory response 27 97.88 Very High Very High Very High
Angina 2 88.24 High High
chemokine 5 85.84 High High
metalloproteinase 4 76.72 Quite High
fifth nerve 6 50.00 Quite Low
ischemia 11 41.28 Quite Low
fibrosis 14 24.60 Low Low
Mechanotransduction 1 11.12 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 113 99.92 Very High Very High Very High
Pathologic Constriction 2 99.48 Very High Very High Very High
Cold Sores 122 93.68 High High
Cytomegalovirus Infection 2 93.04 High High
Targeted Disruption 7 88.72 High High
Viral Meningitis 64 87.28 High High
Injury 19 84.04 Quite High
Cv General 3 Under Development 2 83.60 Quite High
Infection 65 81.28 Quite High
Arterial Occlusive Diseases 2 77.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surface Tlr2 on DCs and macrophages also bind virus glycoproteins and result in production of pro-inflammatory response [4].
Tlr2 Binding (bind) of in macrophages associated with inflammatory response
1) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 1.38 Pain Relevance 0.18
Tlr2 is associated with pro-inflammatory cytokine secretion, whereas Tlr9 elicits also the secretion of type I Ifn (Figure 5K).
Tlr2 Binding (associated) of associated with inflammation and cytokine
2) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 1.51 Pain Relevance 0.20
Whole blood was stimulated overnight with the TLR2 ligand Pam3Cys and the TLR4 ligand lipopolysaccharide.
TLR2 Binding (overnight) of in blood
3) Confidence 0.26 Published 2008 Journal Heart Section Body Doc Link 17686802 Disease Relevance 0.16 Pain Relevance 0
Monocyte toll-like receptor 2 and 4 responses and expression following percutaneous coronary intervention: association with lesion stenosis and fractional flow reserve.
toll-like receptor 2 Binding (association) of in Monocyte associated with pathologic constriction
4) Confidence 0.23 Published 2008 Journal Heart Section Title Doc Link 17686802 Disease Relevance 0.10 Pain Relevance 0.13
After incubation with TLR2, TLR4, I?
TLR2 Binding (incubation) of
5) Confidence 0.16 Published 2010 Journal Respir Res Section Body Doc Link PMC2841148 Disease Relevance 0 Pain Relevance 0
Fragments of ECM proteins and hyaluronan have the ability to promote inflammation by binding Toll-like receptors (TLR)-4 and TLR-2 [81], by activating the transcriptional regulatory complex of nuclear factor (NF)?
TLR-2 Binding (binding) of associated with inflammation
6) Confidence 0.04 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2637833 Disease Relevance 0.44 Pain Relevance 0.38

General Comments

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