INT145761

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.97
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tlr2) cytoplasm (Tlr2)
Tlr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 2 96.20 Very High Very High Very High
cytokine 13 95.28 Very High Very High Very High
Inflammation 22 94.92 High High
fifth nerve 6 5.00 Very Low Very Low Very Low
trigeminal ganglion 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cold Sores 122 96.20 Very High Very High Very High
INFLAMMATION 28 94.92 High High
Sprains And Strains 94 88.04 High High
Cytomegalovirus Infection 2 86.36 High High
Targeted Disruption 4 82.04 Quite High
Viral Meningitis 64 80.60 Quite High
Infection 58 71.72 Quite High
Cv General 3 Under Development 1 62.56 Quite High
Arterial Occlusive Diseases 1 56.88 Quite High
Herpes Simplex Virus 8 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A Tlr2 signaling defect in DA rats could lead to impaired immune activation contributing to the spread/replication of HSV-1.
Negative_regulation (defect) of Tlr2 associated with cold sores
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.52 Pain Relevance 0.05
Furthermore, 2 hours after PCI a significant decrease in TLR2 and TLR4 response (p<0.001) and TLR2 and TLR4 expression (p = 0.001 and p = 0.068, respectively) was seen.
Negative_regulation (decrease) of TLR2
2) Confidence 0.41 Published 2008 Journal Heart Section Body Doc Link 17686802 Disease Relevance 0.12 Pain Relevance 0
Our results determine a host dependent difference of Tlr2 and -9 expression with a subsequent difference in Tnf?
Spec (determine) Negative_regulation (difference) of Tlr2
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 1.34 Pain Relevance 0.19

General Comments

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