INT145768

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 8.31
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR4) plasma membrane (TLR4) intracellular (TLR4)
cytoplasm (TLR4)
Anatomy Link Frequency
nasal mucosa 2
MD2 1
platelet 1
fibroblasts 1
nervous system 1
TLR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 1 100.00 Very High Very High Very High
Inflammation 252 99.84 Very High Very High Very High
endometriosis 21 99.40 Very High Very High Very High
tolerance 17 99.24 Very High Very High Very High
spinal inflammation 10 99.24 Very High Very High Very High
Central nervous system 5 99.12 Very High Very High Very High
Arthritis 5 98.56 Very High Very High Very High
Lasting pain 1 97.52 Very High Very High Very High
Inflammatory mediators 12 97.00 Very High Very High Very High
Inflammatory response 63 94.44 High High
Disease Link Frequency Relevance Heat
Cirrhosis 122 99.96 Very High Very High Very High
INFLAMMATION 307 99.84 Very High Very High Very High
Endometriosis (extended) 38 99.40 Very High Very High Very High
Low Back Pain 10 99.24 Very High Very High Very High
Neonatal Necrotizing Enterocolitis 102 98.76 Very High Very High Very High
Disease 194 98.64 Very High Very High Very High
Seronegative Spondarthritis 1 98.56 Very High Very High Very High
Graft Vs Host Disease 2 98.36 Very High Very High Very High
Rhinitis 52 98.00 Very High Very High Very High
Sepsis 12 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, toll-like receptor 4 (TLR4) has emerged as a therapeutic target for the treatment of CNS-related diseases such as sepsis and chronic pain.
Regulation (target) of toll-like receptor 4 in CNS associated with lasting pain, central nervous system, disease and sepsis
1) Confidence 0.45 Published 2009 Journal Chembiochem Section Abstract Doc Link 19184989 Disease Relevance 0.29 Pain Relevance 0.28
Pharmacological inhibition of endotoxin responses has also been achieved by targeting the TLR4 co-receptor, MD2 [149].
Regulation (targeting) of TLR4 in MD2
2) Confidence 0.42 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.17 Pain Relevance 0.33
We have recently found evidence of an important role for TLR4 in experimental reactive arthritis, raising the question to be addressed whether genetic polymorphisms in TLR4 affects susceptibility to AS.
Spec (whether) Regulation (affects) of TLR4 associated with seronegative spondarthritis, spinal inflammation and arthritis
3) Confidence 0.40 Published 2008 Journal Rheumatol. Int. Section Abstract Doc Link 18034244 Disease Relevance 0.80 Pain Relevance 0.56
These results indicate that stimulation with PAF activates STAT3, a transcription factor that may be involved in TLR4 transcriptional regulation.


Regulation (regulation) of TLR4
4) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0 Pain Relevance 0
Systemic TLR2 and TLR4 response and expression decrease after PCI.
Regulation (response) of TLR4
5) Confidence 0.33 Published 2008 Journal Heart Section Body Doc Link 17686802 Disease Relevance 0.05 Pain Relevance 0
OBJECTIVE: To examine the effect of a percutaneous coronary intervention (PCI) on TLR2 and TLR4 response and expression.
Regulation (response) of TLR4
6) Confidence 0.33 Published 2008 Journal Heart Section Body Doc Link 17686802 Disease Relevance 0.19 Pain Relevance 0
The data on HO-1, TLR2, TLR4, and TNF-?
Regulation (data) of TLR4
7) Confidence 0.32 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.15 Pain Relevance 0
CONCLUSION: Up-regulation of TLR4 in IBS patients may contribute to occurrence of IBS.
Regulation (regulation) of TLR4
8) Confidence 0.32 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 19159572 Disease Relevance 0 Pain Relevance 0
TLR4 regulation is altered in monocytes from patients with cirrhosis.
Regulation (regulation) of TLR4 in monocytes associated with cirrhosis
9) Confidence 0.25 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.33 Pain Relevance 0.49
Roles of TLR2, TLR4, NOD2, and NOD1 in pulp fibroblasts.
Regulation (Roles) of TLR4 in fibroblasts associated with cox2
10) Confidence 0.24 Published 2009 Journal J. Dent. Res. Section Title Doc Link 19734466 Disease Relevance 0.51 Pain Relevance 0.55
The present review traces new efforts to characterize and control toll-like receptor 4 in inflammatory etiologies of the nervous system.
Regulation (control) of toll-like receptor 4 in nervous system associated with inflammation
11) Confidence 0.23 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20402965 Disease Relevance 0.44 Pain Relevance 0.14
B [33], both of which have been implicated in TLR4 signaling and/or gene expression regulation [34].
Regulation (regulation) of TLR4
12) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.05 Pain Relevance 0.05
We have previously shown that platelet activating factor (PAF), bacteria and TLR4 are all important factors in the development of NEC.
Regulation (important) of TLR4 in platelet associated with neonatal necrotizing enterocolitis
13) Confidence 0.22 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955554 Disease Relevance 0.45 Pain Relevance 0
An up-regulation of TLR2, TLR3 and TLR4 in the nasal mucosa of patients with symptomatic allergic rhinitis supports the idea of a role for TLRs in allergic inflammation.
Regulation (regulation) of TLR4 in nasal mucosa associated with rhinitis, inflammation and hypersensitivity
14) Confidence 0.21 Published 2005 Journal Respir Res Section Body Doc Link PMC1243240 Disease Relevance 1.24 Pain Relevance 0.21
However, a later report from Ueta et al. [17] showed that LPS incubation had no effect on TLR4 surface distribution or IL-6 and IL-8 secretion in either primary cultured or immortalized human corneal epithelial cells.
Neg (no) Regulation (effect) of TLR4 in corneal epithelial cells
15) Confidence 0.21 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.15 Pain Relevance 0.12
No effect of forced HO-1 expression on TLR2 and TLR4 mRNA in human PBMCs
Neg (No) Regulation (effect) of TLR4
16) Confidence 0.19 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.16 Pain Relevance 0.05
TLR3 and TLR4 expression is deregulated in peritoneal endometriosis
Regulation (deregulated) of TLR4 associated with endometriosis
17) Confidence 0.19 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.10 Pain Relevance 0.05
In another study, TLR4 immunoreactivity was detected in nasal mucosa from both children and adults irrespective of atopy status, revealing a higher expression level among children [17].
Regulation (immunoreactivity) of TLR4 in nasal mucosa associated with rhinitis
18) Confidence 0.19 Published 2005 Journal Respir Res Section Body Doc Link PMC1243240 Disease Relevance 0.73 Pain Relevance 0.06
Furthermore, 2 hours after PCI a significant decrease in TLR2 and TLR4 response (p<0.001) and TLR2 and TLR4 expression (p = 0.001 and p = 0.068, respectively) was seen.
Regulation (response) of TLR4
19) Confidence 0.14 Published 2008 Journal Heart Section Body Doc Link 17686802 Disease Relevance 0.12 Pain Relevance 0
TLR4 expression control may be a novel target for ACS treatment.


Regulation (control) of TLR4
20) Confidence 0.14 Published 2009 Journal Circ. J. Section Body Doc Link 19556696 Disease Relevance 0.13 Pain Relevance 0

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