INT145775

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Context Info
Confidence 0.72
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 7.71
Pain Relevance 11.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) signal transduction (Ngf) extracellular space (Ngf)
aging (Ngf) extracellular region (Ngf) plasma membrane (Trpv1)
Anatomy Link Frequency
macrophages 1
neurons 1
nociceptors 1
mast cells 1
Ngf (Rattus norvegicus)
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 904 100.00 Very High Very High Very High
Calcitonin gene-related peptide 864 100.00 Very High Very High Very High
qutenza 502 100.00 Very High Very High Very High
Inflammation 56 100.00 Very High Very High Very High
trigeminal ganglion 531 99.24 Very High Very High Very High
Eae 9 99.04 Very High Very High Very High
Hyperalgesia 27 97.52 Very High Very High Very High
Thermal hyperalgesia 33 97.20 Very High Very High Very High
c fibre 39 95.84 Very High Very High Very High
Pain 135 93.84 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 47 100.00 Very High Very High Very High
Ganglion Cysts 703 99.24 Very High Very High Very High
Injury 207 99.04 Very High Very High Very High
Hyperalgesia 69 97.52 Very High Very High Very High
Cancer 160 96.08 Very High Very High Very High
Pain 147 93.84 High High
Nociception 92 87.36 High High
Bone Cancer 56 83.12 Quite High
Neuropathic Pain 10 44.08 Quite Low
Hypersensitivity 18 39.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NGF, in the setting of inflammation, is known to increase TRPV1 protein, but not mRNA, through activation of the p38/MAP kinase pathway [25,26], and NGF-mediated upregulation of TRPV1 is blocked by over-expression of dominant-negative ras [26].
NGF Neg (not) Positive_regulation (increase) of TRPV1 protein associated with inflammation and nerve growth factor
1) Confidence 0.72 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.56 Pain Relevance 0.82
NGF and GDNF each increased TRPV1 protein, and both upregulated the CGRP content of TG neurons.
NGF Positive_regulation (increased) of TRPV1 protein in neurons associated with nerve growth factor, trigeminal ganglion and calcitonin gene-related peptide
2) Confidence 0.72 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.70 Pain Relevance 0.77
NGF and GDNF (100 ng/ml) each was demonstrated to have increased TRPV1 protein levels by approximately 50% compared with no growth factor-treated cultures (Fig 5).
NGF Positive_regulation (increased) of TRPV1 protein associated with nerve growth factor
3) Confidence 0.72 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.14 Pain Relevance 0.63
Additionally, NGF increases capsaicin (CAP) sensitivity both in vivo and in vitro [20-24].
NGF Positive_regulation (increases) of capsaicin associated with qutenza and nerve growth factor
4) Confidence 0.63 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.84 Pain Relevance 1.41
In accordance with this increased CAP sensitivity, NGF increases the expression of the CAP- and noxious heat-sensitive ion channel vanilloid receptor type 1 (TRPV1) through the ras/p38 MAP kinase signaling pathway, thereby promoting thermal hyperalgesia [25,26].
NGF Positive_regulation (increases) of TRPV1 associated with nerve growth factor, qutenza and thermal hyperalgesia
5) Confidence 0.52 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.90 Pain Relevance 1.55
In accordance with this increased CAP sensitivity, NGF increases the expression of the CAP- and noxious heat-sensitive ion channel vanilloid receptor type 1 (TRPV1) through the ras/p38 MAP kinase signaling pathway, thereby promoting thermal hyperalgesia [25,26].
NGF Positive_regulation (increases) of vanilloid receptor type 1 associated with nerve growth factor, qutenza and thermal hyperalgesia
6) Confidence 0.52 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.90 Pain Relevance 1.55
NGF might increase the sensitivity of nociceptors by increasing the SP mRNA or VR1 mRNA.


NGF Positive_regulation (increasing) of VR1 mRNA in nociceptors
7) Confidence 0.51 Published 2007 Journal Neuroscience bulletin Section Body Doc Link 17687396 Disease Relevance 0.06 Pain Relevance 0
Both the NGF- and GDNF-induced upregulation of TRPV1 appears to be translationally regulated, as neither of these growth factors altered TRPV1 mRNA levels.
NGF Positive_regulation (upregulation) of TRPV1 associated with nerve growth factor
8) Confidence 0.49 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.59 Pain Relevance 0.71
Furthermore, NGF and GDNF increased the releasable pool and total content of CGRP while increasing TRPV1 protein, without increasing its mRNA.
NGF Positive_regulation (increasing) of TRPV1 protein associated with nerve growth factor and calcitonin gene-related peptide
9) Confidence 0.49 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.63 Pain Relevance 1.36
NGF, in the setting of inflammation, is known to increase TRPV1 protein, but not mRNA, through activation of the p38/MAP kinase pathway [25,26], and NGF-mediated upregulation of TRPV1 is blocked by over-expression of dominant-negative ras [26].
NGF-mediated Positive_regulation (upregulation) of TRPV1 associated with inflammation and nerve growth factor
10) Confidence 0.49 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.52 Pain Relevance 0.84
Moreover, formaldehyde up-regulated NGF expression in mast cells in vitro, and NGF secreted by mast cells and macrophages could up-regulate TRPV1 [2].
NGF Positive_regulation (regulate) of TRPV1 in macrophages
11) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858155 Disease Relevance 0.94 Pain Relevance 0.80
Moreover, formaldehyde up-regulated NGF expression in mast cells in vitro, and NGF secreted by mast cells and macrophages could up-regulate TRPV1 [2].
NGF Positive_regulation (regulate) of TRPV1 in mast cells
12) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858155 Disease Relevance 0.94 Pain Relevance 0.80

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