INT1458

Context Info Confidence 0.53 First Reported 1978 Last Reported 2006 Negated 1 Speculated 0 Reported most in Abstract Documents 12 Total Number 13 Disease Relevance 0.07 Pain Relevance 10.17

extracellular region (Penk)

Anatomy Mention Frequency brain 3 nerves 1 Penk (Rattus norvegicus)

Pain Term Frequency Confidence Heat opiate 47 100.00 Enkephalin 66 100.00 Morphine 4 100.00 Opioid 3 99.12 narcan 4 98.34 Delta opioid receptors 4 98.16 Hippocampus 5 97.28 Neuropeptide 2 96.88 cerebral cortex 4 96.60 Central nervous system 5 80.08

Disease Term Frequency Confidence Heat Urological Neuroanatomy 1 72.76 Osteoporosis 2 37.52 Arthritis 2 31.68 Experimental Arthritis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In vitro, lithium ions inhibited enkephalin binding to opiate receptors through a reduction in the number of binding sites, whereas the affinity was unchanged or only slightly decreased.

opiate receptors Binding (binding) of enkephalin associated with opiate and enkephalin

1) Confidence 0.53 Published 1982 Journal Neuropharmacology Section Abstract Doc Link 6289161 Disease Relevance 0 Pain Relevance 0.74

Methionine-enkephalin (met-enk), an endogenous opiate, mimics many of the effects of morphine by binding to opiate receptors, thereby eliciting similar cellular and behavioral effects.

opiate receptors Binding (binding) of met-enk associated with opiate, enkephalin and morphine

2) Confidence 0.47 Published 1998 Journal J. Bone Miner. Res. Section Abstract Doc Link 9443794 Disease Relevance 0 Pain Relevance 0.47

Methionine-enkephalin (met-enk), an endogenous opiate, mimics many of the effects of morphine by binding to opiate receptors, thereby eliciting similar cellular and behavioral effects.

opiate receptors Binding (binding) of Methionine-enkephalin associated with opiate, enkephalin and morphine

3) Confidence 0.47 Published 1998 Journal J. Bone Miner. Res. Section Abstract Doc Link 9443794 Disease Relevance 0 Pain Relevance 0.47

It was shown that the Leu-enkephalin D analog interacts with the high and low affinity binding sites of opiate receptors, the equilibrium constants being equal to 0.71 and 8.4 nM, respectively.

opiate receptors Binding (interacts) of Leu-enkephalin associated with opiate and enkephalin

4) Confidence 0.46 Published 1981 Journal Biokhimiia Section Abstract Doc Link 6266517 Disease Relevance 0 Pain Relevance 0.68

3H-Methionine enkephalin binds stereospecifically with high affinity to opiate receptors in rat brain membranes.

opiate receptors Binding (binds) of enkephalin in brain associated with opiate and enkephalin

5) Confidence 0.40 Published 1978 Journal Eur. J. Pharmacol. Section Abstract Doc Link 204498 Disease Relevance 0 Pain Relevance 1.16

In vitro and in vivo inhibition by lithium of enkephalin binding to opiate receptors in rat brain.

opiate receptors Binding (binding) of enkephalin in brain associated with opiate and enkephalin

6) Confidence 0.40 Published 1982 Journal Neuropharmacology Section Title Doc Link 6289161 Disease Relevance 0 Pain Relevance 1.07

Inhibition of enkephalin binding to opiate receptors by zinc ions: possible physiological importance in the brain.

opiate receptors Binding (binding) of enkephalin in brain associated with opiate and enkephalin

7) Confidence 0.39 Published 1982 Journal Acta Pharmacol Toxicol (Copenh) Section Title Doc Link 6283789 Disease Relevance 0 Pain Relevance 0.90

(b) The CCK immunoreactive nerves display a distribution similar to that of enkephalin, but the main endogenous CCK forms do not bind to opiate receptors.

opiate receptors Neg (not) Binding (bind) of enkephalin in nerves associated with opiate and enkephalin

8) Confidence 0.32 Published 1981 Journal Peptides Section Abstract Doc Link 6267560 Disease Relevance 0 Pain Relevance 1.06

[The effect of modification of the carboxyl group in short D-arginine 2-containing enkephalin analogs on their affinity and selectivity for opiate receptors].

opiate receptors Binding (affinity) of enkephalin associated with narcan, opiate and enkephalin

9) Confidence 0.29 Published 1990 Journal Ukr. Biokhim. Zh. Section Title Doc Link 2173185 Disease Relevance 0 Pain Relevance 0.80

From the results it could be concluded that Leu-enkephalin binds in a turn conformation to the opiate receptors, but that this conformation is not a (1-4) beta-turn.

opiate receptors Binding (binds) of Leu-enkephalin associated with opiate and enkephalin

10) Confidence 0.20 Published 2006 Journal Org. Biomol. Chem. Section Abstract Doc Link 16446799 Disease Relevance 0 Pain Relevance 0.60

This may suggest that enkephalin, CCK, ACTH and beta-endorphin may interact with each other and with opiate receptors.

opiate receptors Binding (interact) of enkephalin associated with opiate and enkephalin

11) Confidence 0.20 Published 1981 Journal Histochemistry Section Abstract Doc Link 6274830 Disease Relevance 0.07 Pain Relevance 0.96

From the results it could be concluded that Leu-enkephalin binds in a turn conformation to the opiate receptors, but that this conformation is not a (1-4) beta-turn.

opiate receptors Binding (binds) of Leu-enkephalin associated with opiate and enkephalin

12) Confidence 0.16 Published 2006 Journal Org. Biomol. Chem. Section Abstract Doc Link 16446799 Disease Relevance 0 Pain Relevance 0.60

Interaction of dimers of inactive enkephalin fragments with mu opiate receptors.

opiate receptors Binding (Interaction) of enkephalin associated with opiate and enkephalin

13) Confidence 0.05 Published 1987 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 3039993 Disease Relevance 0 Pain Relevance 0.65

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