INT1458

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Context Info
Confidence 0.53
First Reported 1978
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 0.07
Pain Relevance 10.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Mention Frequency
brain 3
nerves 1
Penk (Rattus norvegicus)
Pain Term Frequency Confidence Heat
opiate 47 100.00 Very High Very High Very High
Enkephalin 66 100.00 Very High Very High Very High
Morphine 4 100.00 Very High Very High Very High
Opioid 3 99.12 Very High Very High Very High
narcan 4 98.34 Very High Very High Very High
Delta opioid receptors 4 98.16 Very High Very High Very High
Hippocampus 5 97.28 Very High Very High Very High
Neuropeptide 2 96.88 Very High Very High Very High
cerebral cortex 4 96.60 Very High Very High Very High
Central nervous system 5 80.08 Quite High
Disease Term Frequency Confidence Heat
Urological Neuroanatomy 1 72.76 Quite High
Osteoporosis 2 37.52 Quite Low
Arthritis 2 31.68 Quite Low
Experimental Arthritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro, lithium ions inhibited enkephalin binding to opiate receptors through a reduction in the number of binding sites, whereas the affinity was unchanged or only slightly decreased.
opiate receptors Binding (binding) of enkephalin associated with opiate and enkephalin
1) Confidence 0.53 Published 1982 Journal Neuropharmacology Section Abstract Doc Link 6289161 Disease Relevance 0 Pain Relevance 0.74
Methionine-enkephalin (met-enk), an endogenous opiate, mimics many of the effects of morphine by binding to opiate receptors, thereby eliciting similar cellular and behavioral effects.
opiate receptors Binding (binding) of met-enk associated with opiate, enkephalin and morphine
2) Confidence 0.47 Published 1998 Journal J. Bone Miner. Res. Section Abstract Doc Link 9443794 Disease Relevance 0 Pain Relevance 0.47
Methionine-enkephalin (met-enk), an endogenous opiate, mimics many of the effects of morphine by binding to opiate receptors, thereby eliciting similar cellular and behavioral effects.
opiate receptors Binding (binding) of Methionine-enkephalin associated with opiate, enkephalin and morphine
3) Confidence 0.47 Published 1998 Journal J. Bone Miner. Res. Section Abstract Doc Link 9443794 Disease Relevance 0 Pain Relevance 0.47
It was shown that the Leu-enkephalin D analog interacts with the high and low affinity binding sites of opiate receptors, the equilibrium constants being equal to 0.71 and 8.4 nM, respectively.
opiate receptors Binding (interacts) of Leu-enkephalin associated with opiate and enkephalin
4) Confidence 0.46 Published 1981 Journal Biokhimiia Section Abstract Doc Link 6266517 Disease Relevance 0 Pain Relevance 0.68
3H-Methionine enkephalin binds stereospecifically with high affinity to opiate receptors in rat brain membranes.
opiate receptors Binding (binds) of enkephalin in brain associated with opiate and enkephalin
5) Confidence 0.40 Published 1978 Journal Eur. J. Pharmacol. Section Abstract Doc Link 204498 Disease Relevance 0 Pain Relevance 1.16
In vitro and in vivo inhibition by lithium of enkephalin binding to opiate receptors in rat brain.
opiate receptors Binding (binding) of enkephalin in brain associated with opiate and enkephalin
6) Confidence 0.40 Published 1982 Journal Neuropharmacology Section Title Doc Link 6289161 Disease Relevance 0 Pain Relevance 1.07
Inhibition of enkephalin binding to opiate receptors by zinc ions: possible physiological importance in the brain.
opiate receptors Binding (binding) of enkephalin in brain associated with opiate and enkephalin
7) Confidence 0.39 Published 1982 Journal Acta Pharmacol Toxicol (Copenh) Section Title Doc Link 6283789 Disease Relevance 0 Pain Relevance 0.90
(b) The CCK immunoreactive nerves display a distribution similar to that of enkephalin, but the main endogenous CCK forms do not bind to opiate receptors.
opiate receptors Neg (not) Binding (bind) of enkephalin in nerves associated with opiate and enkephalin
8) Confidence 0.32 Published 1981 Journal Peptides Section Abstract Doc Link 6267560 Disease Relevance 0 Pain Relevance 1.06
[The effect of modification of the carboxyl group in short D-arginine 2-containing enkephalin analogs on their affinity and selectivity for opiate receptors].
opiate receptors Binding (affinity) of enkephalin associated with narcan, opiate and enkephalin
9) Confidence 0.29 Published 1990 Journal Ukr. Biokhim. Zh. Section Title Doc Link 2173185 Disease Relevance 0 Pain Relevance 0.80
From the results it could be concluded that Leu-enkephalin binds in a turn conformation to the opiate receptors, but that this conformation is not a (1-4) beta-turn.
opiate receptors Binding (binds) of Leu-enkephalin associated with opiate and enkephalin
10) Confidence 0.20 Published 2006 Journal Org. Biomol. Chem. Section Abstract Doc Link 16446799 Disease Relevance 0 Pain Relevance 0.60
This may suggest that enkephalin, CCK, ACTH and beta-endorphin may interact with each other and with opiate receptors.
opiate receptors Binding (interact) of enkephalin associated with opiate and enkephalin
11) Confidence 0.20 Published 1981 Journal Histochemistry Section Abstract Doc Link 6274830 Disease Relevance 0.07 Pain Relevance 0.96
From the results it could be concluded that Leu-enkephalin binds in a turn conformation to the opiate receptors, but that this conformation is not a (1-4) beta-turn.
opiate receptors Binding (binds) of Leu-enkephalin associated with opiate and enkephalin
12) Confidence 0.16 Published 2006 Journal Org. Biomol. Chem. Section Abstract Doc Link 16446799 Disease Relevance 0 Pain Relevance 0.60
Interaction of dimers of inactive enkephalin fragments with mu opiate receptors.
opiate receptors Binding (Interaction) of enkephalin associated with opiate and enkephalin
13) Confidence 0.05 Published 1987 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 3039993 Disease Relevance 0 Pain Relevance 0.65

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