INT145801

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.89
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cysltr1) plasma membrane (Cysltr1) signal transducer activity (Cysltr1)
Cysltr1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 5 100.00 Very High Very High Very High
Inflammation 6 78.92 Quite High
Neuropeptide 1 65.68 Quite High
aspirin 7 64.72 Quite High
Migraine 1 40.40 Quite Low
corticosteroid 24 38.56 Quite Low
agonist 15 35.08 Quite Low
fibrosis 1 33.44 Quite Low
tolerance 2 33.28 Quite Low
Bioavailability 3 17.12 Low Low
Disease Link Frequency Relevance Heat
Chronic Disease 2 97.64 Very High Very High Very High
Asthma 85 96.48 Very High Very High Very High
Rhinitis 4 95.64 Very High Very High Very High
Anaphylaxis 1 92.52 High High
Edema 1 85.36 High High
INFLAMMATION 8 78.92 Quite High
Dyspnea 2 67.12 Quite High
Disease 6 64.64 Quite High
Pulmonary Disease 1 58.48 Quite High
Interstitial Lung Diseases 1 55.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By competitive binding to the Cys-LT(1) receptor, leukotriene receptor antagonist drugs such as montelukast, zafirlukast, and pranlukast, block the effects of Cys-LTs and alleviate the symptoms of many chronic diseases, especially bronchial asthma and allergic rhinitis.
Negative_regulation (block) of Cys-LT Binding (binding) of associated with asthma, rhinitis, antagonist and chronic disease
1) Confidence 0.39 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17691939 Disease Relevance 0.97 Pain Relevance 0.09
The leukotriene receptor antagonists (LTRAs) selectively block the binding of cysteinyl leukotrienes to the CysLT1 receptor, which has been identified as the receptor through which most of their actions are mediated (Drazen et al 1999).
Negative_regulation (block) of CysLT1 receptor Binding (binding) of associated with antagonist
2) Confidence 0.21 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376066 Disease Relevance 0.93 Pain Relevance 0.26

General Comments

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