INT14581

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Context Info
Confidence 0.45
First Reported 1990
Last Reported 2007
Negated 2
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.58
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
neuronal 2
sympathetic 2
Sst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 31 100.00 Very High Very High Very High
Paracetamol 7 99.84 Very High Very High Very High
tetrodotoxin 2 99.08 Very High Very High Very High
Antinociceptive 2 98.36 Very High Very High Very High
Potency 1 97.12 Very High Very High Very High
antagonist 2 96.60 Very High Very High Very High
antinociception 3 94.00 High High
Cholecystokinin 1 81.40 Quite High
Pain 4 80.96 Quite High
addiction 1 78.36 Quite High
Disease Link Frequency Relevance Heat
Death 1 92.48 High High
Convulsion 1 92.04 High High
Nociception 4 88.28 High High
Natriuresis 2 81.12 Quite High
Pain 1 80.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sham operations also affected the effectiveness of somatostatin.
Regulation (affected) of Negative_regulation (effectiveness) of somatostatin associated with somatostatin
1) Confidence 0.45 Published 1990 Journal Life Sci. Section Abstract Doc Link 1978215 Disease Relevance 0.35 Pain Relevance 0.42
The inhibitory effect of somatostatin on amylase output was not affected by cholinergic receptor blockade with atropine (328 +/- 65 U/30 min) or by sympathetic ganglionic blockade with hexamethonium (360 +/- 68 U/30 min).
Neg (not) Regulation (affected) of Negative_regulation (effect) of somatostatin in sympathetic associated with somatostatin
2) Confidence 0.43 Published 1990 Journal Metab. Clin. Exp. Section Abstract Doc Link 1698248 Disease Relevance 0 Pain Relevance 0.50
The somatostatin response to ANP was unaffected by the axonal blocker tetrodotoxin but abolished by addition of the selective NPR-A antagonist, anantin.
Neg (unaffected) Regulation (unaffected) of Neg (unaffected) Negative_regulation (unaffected) of somatostatin associated with tetrodotoxin, antagonist and somatostatin
3) Confidence 0.26 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12527142 Disease Relevance 0.16 Pain Relevance 0.58
Indeed, down-regulation of sst3R mRNA depends on acetaminophen-elicited, 5-HT1A receptor-dependent increase in neuronal extracellular signal-regulated kinase 1/2 (ERK1/2) activities that mediate antinociception.
Regulation (depends) of Negative_regulation (regulation) of sst3R in neuronal associated with antinociception and paracetamol
4) Confidence 0.01 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17088403 Disease Relevance 0.08 Pain Relevance 1.10

General Comments

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