INT14582

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Context Info
Confidence 0.56
First Reported 1982
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 0.52
Pain Relevance 8.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
neuronal 4
neurons 2
lamina 2
Sst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 69 100.00 Very High Very High Very High
gABA 12 100.00 Very High Very High Very High
Clonidine 9 100.00 Very High Very High Very High
Opioid 6 100.00 Very High Very High Very High
substance P 5 100.00 Very High Very High Very High
Paracetamol 7 99.60 Very High Very High Very High
MU agonist 10 99.46 Very High Very High Very High
tetrodotoxin 4 99.46 Very High Very High Very High
antagonist 3 98.94 Very High Very High Very High
GABA receptor 1 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bordatella Infection 2 99.12 Very High Very High Very High
Fistula 1 86.96 High High
Pain 1 81.16 Quite High
Convulsion 2 77.28 Quite High
Nociception 4 62.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blockade of axonal neuronal transmission by tetrodotoxin (10(-7) mol/L) completely abolished the inhibitory effect of somatostatin (992 +/- 53 U/30 min).
Negative_regulation (abolished) of Negative_regulation (effect) of somatostatin in neuronal associated with tetrodotoxin and somatostatin
1) Confidence 0.56 Published 1990 Journal Metab. Clin. Exp. Section Abstract Doc Link 1698248 Disease Relevance 0 Pain Relevance 0.49
Somatostatin monoclonal antibody injected intravenously (2 mg) completely reversed the inhibitory effect of somatostatin (20 micrograms/kg.h) on pentagastrin (24 micrograms/kg.h)-stimulated gastric acid secretion.
Negative_regulation (reversed) of Negative_regulation (effect) of somatostatin associated with somatostatin
2) Confidence 0.42 Published 1990 Journal Gastroenterology Section Abstract Doc Link 1974217 Disease Relevance 0.09 Pain Relevance 0.51
These results indicate that the prolonged activation of somatostatin receptors induces the desensitization of somatostatin-induced inhibition on low [Mg(2+)](o)-induced [Ca(2+)](i) spikes through the activation of GRK2 and partly a novel PKCepsilon in cultured rat hippocampal neurons.
Negative_regulation (desensitization) of Negative_regulation (inhibition) of somatostatin-induced in neurons associated with somatostatin
3) Confidence 0.40 Published 2006 Journal Brain Res. Section Abstract Doc Link 16879804 Disease Relevance 0.06 Pain Relevance 0.55
The inhibitory effects of somatostatin were blocked by pretreatment with pertussis toxin (PTX, 100 ng/ml) for 18-24 h.
Negative_regulation (blocked) of Negative_regulation (effects) of somatostatin associated with bordatella infection and somatostatin
4) Confidence 0.40 Published 2006 Journal Brain Res. Section Abstract Doc Link 16879804 Disease Relevance 0.18 Pain Relevance 0.46
The GABA receptor antagonist, bicuculline methiodide, at 10(-5) but not 10(-6) M attenuated the GABA-induced inhibition of somatostatin release.
Negative_regulation (attenuated) of Negative_regulation (inhibition) of somatostatin associated with gaba, antagonist, gaba receptor and somatostatin
5) Confidence 0.37 Published 1990 Journal Brain Res. Section Abstract Doc Link 1967972 Disease Relevance 0.12 Pain Relevance 0.97
Inclusion of either atropine or pirenzepine in incubation medium prevented GABA-induced stimulation of gastrin release and inhibition of somatostatin release.
Negative_regulation (prevented) of Negative_regulation (inhibition) of somatostatin associated with gaba and somatostatin
6) Confidence 0.34 Published 1986 Journal Gastroenterology Section Abstract Doc Link 2875917 Disease Relevance 0 Pain Relevance 0.73
These results were confirmed by parallel immunocytochemical analysis which localised the dramatic decreases of substance P and somatostatin to lamina 1 and lamina 2.
Negative_regulation (localised) of Negative_regulation (decreases) of somatostatin in lamina associated with somatostatin and substance p
7) Confidence 0.31 Published 1982 Journal Neuroscience Section Abstract Doc Link 7162630 Disease Relevance 0 Pain Relevance 1.19
PO/AHA idazoxan 10 nmol prevented GH release caused by both clonidine and DAGO, suggesting that idazoxan prevents opioid-induced as well as clonidine-induced suppression of somatostatin release.
Negative_regulation (prevents) of Negative_regulation (suppression) of somatostatin associated with mu agonist, somatostatin, opioid and clonidine
8) Confidence 0.20 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8105398 Disease Relevance 0 Pain Relevance 2.38
Indeed, down-regulation of sst3R mRNA depends on acetaminophen-elicited, 5-HT1A receptor-dependent increase in neuronal extracellular signal-regulated kinase 1/2 (ERK1/2) activities that mediate antinociception.
Negative_regulation (down) of Negative_regulation (regulation) of sst3R in neuronal associated with antinociception and paracetamol
9) Confidence 0.02 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17088403 Disease Relevance 0.08 Pain Relevance 1.10

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