INT145821

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Context Info
Confidence 0.41
First Reported 2002
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 8.05
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) protein complex (Mapk1)
cytoplasm (Mapk1) cytosol (Mapk1) signal transduction (Mapk1)
Anatomy Link Frequency
cortex 6
neuronal 4
spinal 2
endothelial cells 2
spinal cords 2
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 80 100.00 Very High Very High Very High
Spinal cord 19 97.56 Very High Very High Very High
Opioid 23 97.52 Very High Very High Very High
Dynorphin 3 96.24 Very High Very High Very High
intrathecal 6 93.08 High High
Pain 23 92.92 High High
Nerve growth factor 3 91.28 High High
Morphine 1 87.08 High High
Inflammation 49 86.56 High High
agonist 30 83.12 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 350 100.00 Very High Very High Very High
Depression 91 100.00 Very High Very High Very High
Cancer 36 100.00 Very High Very High Very High
Congenital Anomalies 41 99.74 Very High Very High Very High
Suicidal Behaviour 10 99.08 Very High Very High Very High
Apoptosis 17 98.08 Very High Very High Very High
Disease 19 97.16 Very High Very High Very High
Aging 125 97.04 Very High Very High Very High
Pain 22 92.92 High High
Obesity 171 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, anti-NGF treatment did not reduce p-ERK and c-Fos expression at 20 and 90 min, respectively, following fracture.
Neg (not) Negative_regulation (reduce) of Gene_expression (expression) of ERK
1) Confidence 0.41 Published 2007 Journal Pain Section Abstract Doc Link 17693023 Disease Relevance 0.93 Pain Relevance 0.94
In the current studies, we do not observe suppressed basal ERK activation in the spinal cords of the DN MEK mice.
Neg (not) Negative_regulation (suppressed) of Gene_expression (activation) of ERK in spinal cords
2) Confidence 0.41 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.40 Pain Relevance 0.28
DSLET-mediated ERK activation was significantly inhibited by the Src kinase inhibitor, PP1 (10 ?
Negative_regulation (inhibited) of Gene_expression (activation) of ERK
3) Confidence 0.39 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0 Pain Relevance 0.16
Moreover, the expression of phosphorylated extracellular signal-regulated kinase (p-ERK) protein was significantly decreased in the prefrontal cortex of HB-EGF KO mice (P<0.05 vs. control mice), despite comparable levels of total ERK expression (Fig. 6d).
Negative_regulation (decreased) of Gene_expression (expression) of ERK in cortex associated with targeted disruption
4) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.91 Pain Relevance 0.04
Moreover, the expression of phosphorylated extracellular signal-regulated kinase (p-ERK) protein was significantly decreased in the prefrontal cortex of HB-EGF KO mice (P<0.05 vs. control mice), despite comparable levels of total ERK expression (Fig. 6d).
Negative_regulation (decreased) of Gene_expression (expression) of p-ERK in cortex associated with targeted disruption
5) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.84 Pain Relevance 0.04
The same PMA treating procedures produced a higher level of phosphorylated ERK peaked at 10 min, then gradually decreased in 30 and 60 min.
Negative_regulation (decreased) of Gene_expression (produced) of ERK
6) Confidence 0.26 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1865092 Disease Relevance 0 Pain Relevance 0.13
Moreover, the expression of phosphorylated extracellular signal-regulated kinase (p-ERK) protein was significantly decreased in the prefrontal cortex of HB-EGF KO mice (P<0.05 vs. control mice), despite comparable levels of total ERK expression (Fig. 6d).
Negative_regulation (decreased) of Gene_expression (expression) of extracellular signal-regulated kinase in cortex associated with targeted disruption
7) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.84 Pain Relevance 0.04
Expression of non-phosphorylated
                   ERK was unaffected by short-term leptin treatment at 1.0 nM. 
Neg (unaffected) Negative_regulation (unaffected) of Gene_expression (Expression) of ERK
8) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.96 Pain Relevance 0
In anaesthetized mice, URB597 (30 microg i.pl.) and biochanin A (100 microg i.pl.) both inhibited the spinal phosphorylation of extracellular signal-regulated kinase produced by the intraplantar injection of formalin.
Negative_regulation (inhibited) of Gene_expression (produced) of extracellular signal-regulated kinase in spinal
9) Confidence 0.16 Published 2010 Journal Br. J. Pharmacol. Section Body Doc Link 20590565 Disease Relevance 0 Pain Relevance 0
Abnormalities in ERK1 and ERK2 have been noted in animal models of depression (Feng et al 2003), and decreased neuronal ERK expression is seen in victims of suicide (Dwivedi et al 2001).
Negative_regulation (decreased) of Gene_expression (expression) of ERK in neuronal associated with suicidal behaviour, depression and congenital anomalies
10) Confidence 0.16 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.53 Pain Relevance 0.21
[18, 19], and reduces expression of the Ras tumor suppressor, NORE1A [20], which inhibits ERK
Negative_regulation (reduces) of Gene_expression (expression) of ERK associated with cancer
11) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430014 Disease Relevance 0.81 Pain Relevance 0.08
Abnormalities in ERK1 and ERK2 have been noted in animal models of depression (Feng et al 2003), and decreased neuronal ERK expression is seen in victims of suicide (Dwivedi et al 2001).
Negative_regulation (decreased) of Gene_expression (expression) of ERK2 in neuronal associated with suicidal behaviour, depression and congenital anomalies
12) Confidence 0.11 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.54 Pain Relevance 0.26
Inhibition of AP-1 expression through suppression of the extracellular receptor kinase (ERK) MAPK pathway activity resulted in significant downregulation of the total level of sigma-1 receptors[14].
Negative_regulation (suppression) of Gene_expression (expression) of ERK
13) Confidence 0.05 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0.19 Pain Relevance 0.21
Inhibition of AP-1 expression through suppression of the extracellular receptor kinase (ERK) MAPK pathway activity resulted in significant downregulation of the total level of sigma-1 receptors[14].
Negative_regulation (Inhibition) of Gene_expression (expression) of ERK
14) Confidence 0.05 Published 2007 Journal J Mol Signal Section Body Doc Link PMC2045653 Disease Relevance 0.19 Pain Relevance 0.21
MAPK ERK1/2 pathway inhibitors blunted IL-6 production following NGF or BDNF exposure
Negative_regulation (inhibitors) of Gene_expression (pathway) of ERK1/2
15) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0 Pain Relevance 0
Moreover, PSP dramatically decreased the levels of phosphorylated AKT and ERK1/2 in endothelial cells.
Negative_regulation (decreased) of Gene_expression (levels) of ERK1/2 in endothelial cells
16) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2751803 Disease Relevance 0.91 Pain Relevance 0.17

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