INT145826

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 7
Disease Relevance 3.05
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca, Igf1) extracellular region (Calca, Igf1) aging (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
sensory neuron 14
Calca (Rattus norvegicus)
Igf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 23 100.00 Very High Very High Very High
Spinal cord 24 97.44 Very High Very High Very High
Inflammatory response 8 95.88 Very High Very High Very High
qutenza 13 75.00 Quite High
dorsal root ganglion 4 61.76 Quite High
antagonist 4 51.84 Quite High
Disease Link Frequency Relevance Heat
Frailty 36 97.44 Very High Very High Very High
Hypertension 6 97.24 Very High Very High Very High
INFLAMMATION 8 95.88 Very High Very High Very High
Injury 12 66.72 Quite High
Ganglion Cysts 4 60.80 Quite High
Cancer 4 25.00 Low Low
Apoptosis 4 25.00 Low Low
Necrosis 4 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Calcitonin gene-related peptide (CGRP) increases IGF-I production in vitro and in vivo, suggesting that stimulation of sensory neurons might increase the production of IGF-I in SHR.
CGRP Positive_regulation (increases) of Gene_expression (production) of IGF-I in sensory neurons
1) Confidence 0.75 Published 2008 Journal Growth Horm. IGF Res. Section Abstract Doc Link 17693108 Disease Relevance 0.17 Pain Relevance 0.12
Calcitonin gene-related peptide (CGRP) increases IGF-I production in vitro and in vivo, suggesting that stimulation of sensory neurons might increase the production of IGF-I in SHR.
Calcitonin gene-related peptide Positive_regulation (increases) of Gene_expression (production) of IGF-I in sensory neurons
2) Confidence 0.75 Published 2008 Journal Growth Horm. IGF Res. Section Abstract Doc Link 17693108 Disease Relevance 0.17 Pain Relevance 0.12
Calcitonin gene-related peptide (CGRP) released from sensory neurons increases the production of a neuroprotective substance insulin-like growth factor I (IGF-I), and sensory neuron stimulation contributes to a reduction of spinal cord injury (SCI) by inhibiting inflammatory responses in rats.
CGRP Positive_regulation (increases) of Gene_expression (production) of insulin-like growth factor I in sensory neuron associated with inflammatory response, frailty, spinal cord and calcitonin gene-related peptide
3) Confidence 0.72 Published 2010 Journal Transl Res Section Abstract Doc Link 20970752 Disease Relevance 0.63 Pain Relevance 0.32
Calcitonin gene-related peptide (CGRP) released from sensory neurons increases the production of a neuroprotective substance insulin-like growth factor I (IGF-I), and sensory neuron stimulation contributes to a reduction of spinal cord injury (SCI) by inhibiting inflammatory responses in rats.
gene-related peptide Positive_regulation (increases) of Gene_expression (production) of insulin-like growth factor I in sensory neuron associated with inflammatory response, frailty, spinal cord and calcitonin gene-related peptide
4) Confidence 0.63 Published 2010 Journal Transl Res Section Abstract Doc Link 20970752 Disease Relevance 0.63 Pain Relevance 0.32
Calcitonin gene-related peptide (CGRP) increases IGF-I production in vitro and in vivo, suggesting that stimulation of sensory neurons might increase the production of IGF-I in SHR.
CGRP Spec (might) Positive_regulation (increase) of Gene_expression (production) of IGF-I in sensory neurons
5) Confidence 0.54 Published 2008 Journal Growth Horm. IGF Res. Section Abstract Doc Link 17693108 Disease Relevance 0.17 Pain Relevance 0.12
Calcitonin gene-related peptide (CGRP) released from sensory neurons increases the production of a neuroprotective substance insulin-like growth factor I (IGF-I), and sensory neuron stimulation contributes to a reduction of spinal cord injury (SCI) by inhibiting inflammatory responses in rats.
CGRP Positive_regulation (increases) of Gene_expression (production) of IGF-I in sensory neuron associated with inflammatory response, frailty, spinal cord and calcitonin gene-related peptide
6) Confidence 0.52 Published 2010 Journal Transl Res Section Abstract Doc Link 20970752 Disease Relevance 0.64 Pain Relevance 0.32
Calcitonin gene-related peptide (CGRP) released from sensory neurons increases the production of a neuroprotective substance insulin-like growth factor I (IGF-I), and sensory neuron stimulation contributes to a reduction of spinal cord injury (SCI) by inhibiting inflammatory responses in rats.
gene-related peptide Positive_regulation (increases) of Gene_expression (production) of IGF-I in sensory neuron associated with inflammatory response, frailty, spinal cord and calcitonin gene-related peptide
7) Confidence 0.45 Published 2010 Journal Transl Res Section Abstract Doc Link 20970752 Disease Relevance 0.64 Pain Relevance 0.32

General Comments

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