INT145826

Context Info Confidence 0.75 First Reported 2008 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 3 Total Number 7 Disease Relevance 3.05 Pain Relevance 1.66

extracellular space (Calca, Igf1) extracellular region (Calca, Igf1) aging (Calca) nucleus (Calca) intracellular (Calca) cytoplasm (Calca)

Anatomy Link Frequency sensory neuron 14 Calca (Rattus norvegicus) Igf1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Calcitonin gene-related peptide 23 100.00 Spinal cord 24 97.44 Inflammatory response 8 95.88 qutenza 13 75.00 dorsal root ganglion 4 61.76 antagonist 4 51.84

Disease Link Frequency Relevance Heat Frailty 36 97.44 Hypertension 6 97.24 INFLAMMATION 8 95.88 Injury 12 66.72 Ganglion Cysts 4 60.80 Cancer 4 25.00 Apoptosis 4 25.00 Necrosis 4 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Calcitonin gene-related peptide (CGRP) increases IGF-I production in vitro and in vivo, suggesting that stimulation of sensory neurons might increase the production of IGF-I in SHR.

CGRP Positive_regulation (increases) of Gene_expression (production) of IGF-I in sensory neurons

1) Confidence 0.75 Published 2008 Journal Growth Horm. IGF Res. Section Abstract Doc Link 17693108 Disease Relevance 0.17 Pain Relevance 0.12

Calcitonin gene-related peptide (CGRP) increases IGF-I production in vitro and in vivo, suggesting that stimulation of sensory neurons might increase the production of IGF-I in SHR.

Calcitonin gene-related peptide Positive_regulation (increases) of Gene_expression (production) of IGF-I in sensory neurons

2) Confidence 0.75 Published 2008 Journal Growth Horm. IGF Res. Section Abstract Doc Link 17693108 Disease Relevance 0.17 Pain Relevance 0.12

Calcitonin gene-related peptide (CGRP) released from sensory neurons increases the production of a neuroprotective substance insulin-like growth factor I (IGF-I), and sensory neuron stimulation contributes to a reduction of spinal cord injury (SCI) by inhibiting inflammatory responses in rats.

CGRP Positive_regulation (increases) of Gene_expression (production) of insulin-like growth factor I in sensory neuron associated with inflammatory response, frailty, spinal cord and calcitonin gene-related peptide

3) Confidence 0.72 Published 2010 Journal Transl Res Section Abstract Doc Link 20970752 Disease Relevance 0.63 Pain Relevance 0.32

Calcitonin gene-related peptide (CGRP) released from sensory neurons increases the production of a neuroprotective substance insulin-like growth factor I (IGF-I), and sensory neuron stimulation contributes to a reduction of spinal cord injury (SCI) by inhibiting inflammatory responses in rats.

gene-related peptide Positive_regulation (increases) of Gene_expression (production) of insulin-like growth factor I in sensory neuron associated with inflammatory response, frailty, spinal cord and calcitonin gene-related peptide

4) Confidence 0.63 Published 2010 Journal Transl Res Section Abstract Doc Link 20970752 Disease Relevance 0.63 Pain Relevance 0.32

Calcitonin gene-related peptide (CGRP) increases IGF-I production in vitro and in vivo, suggesting that stimulation of sensory neurons might increase the production of IGF-I in SHR.

CGRP Spec (might) Positive_regulation (increase) of Gene_expression (production) of IGF-I in sensory neurons

5) Confidence 0.54 Published 2008 Journal Growth Horm. IGF Res. Section Abstract Doc Link 17693108 Disease Relevance 0.17 Pain Relevance 0.12

Calcitonin gene-related peptide (CGRP) released from sensory neurons increases the production of a neuroprotective substance insulin-like growth factor I (IGF-I), and sensory neuron stimulation contributes to a reduction of spinal cord injury (SCI) by inhibiting inflammatory responses in rats.

CGRP Positive_regulation (increases) of Gene_expression (production) of IGF-I in sensory neuron associated with inflammatory response, frailty, spinal cord and calcitonin gene-related peptide

6) Confidence 0.52 Published 2010 Journal Transl Res Section Abstract Doc Link 20970752 Disease Relevance 0.64 Pain Relevance 0.32

Calcitonin gene-related peptide (CGRP) released from sensory neurons increases the production of a neuroprotective substance insulin-like growth factor I (IGF-I), and sensory neuron stimulation contributes to a reduction of spinal cord injury (SCI) by inhibiting inflammatory responses in rats.

gene-related peptide Positive_regulation (increases) of Gene_expression (production) of IGF-I in sensory neuron associated with inflammatory response, frailty, spinal cord and calcitonin gene-related peptide

7) Confidence 0.45 Published 2010 Journal Transl Res Section Abstract Doc Link 20970752 Disease Relevance 0.64 Pain Relevance 0.32

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