INT145853

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.68
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Casp1, Mapk14) nucleus (Casp1, Mapk14) mitochondrion (Mapk14)
cell morphogenesis (Mapk14) intracellular (Casp1) protein complex (Casp1)
Casp1 (Rattus norvegicus)
Mapk14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Thermal hyperalgesia 2 99.14 Very High Very High Very High
central sensitization 1 94.88 High High
IPN 1 93.88 High High
antagonist 1 93.56 High High
allodynia 1 91.68 High High
nociceptor 1 89.76 High High
intrathecal 1 80.64 Quite High
Spinal cord 2 79.04 Quite High
Pain 3 75.00 Quite High
Dorsal horn 1 70.32 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 2 99.14 Very High Very High Very High
Inflammatory Pain 1 93.88 High High
Neuropathic Pain 1 91.68 High High
Nociception 2 79.52 Quite High
Pain 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-1beta-induced NO levels and thermal hyperalgesia in rats, likely via either inhibiting the IL-1beta-mediated p38 MAPK activation and subsequent iNOS induction, or direct attenuation of the central iNOS activity, which therefore reduces the central sensitization of inflammatory pain.
IL-1beta-mediated Spec (likely) Positive_regulation (mediated) of p38 associated with central sensitization, ipn and thermal hyperalgesia
1) Confidence 0.02 Published 2007 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 17694686 Disease Relevance 0.68 Pain Relevance 0.93

General Comments

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