INT14586

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Context Info
Confidence 0.58
First Reported 1986
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 26
Disease Relevance 6.18
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpb1) extracellular region (Cpb1) cellular_component (Cpb1)
biological_process (Cpb1)
Anatomy Link Frequency
blood 11
brains 2
plasma 1
fibroblast 1
stems 1
Cpb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 73 99.70 Very High Very High Very High
Enkephalin 17 99.40 Very High Very High Very High
Inflammation 5 91.68 High High
cva 25 86.88 High High
Neuropeptide 2 79.28 Quite High
Ultiva 20 78.88 Quite High
metalloproteinase 6 75.00 Quite High
Versed 32 74.40 Quite High
Thalamus 4 65.68 Quite High
isoflurane 5 42.48 Quite Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 79 99.88 Very High Very High Very High
Heart Rate Under Development 61 93.88 High High
Emergencies 23 91.72 High High
INFLAMMATION 8 91.68 High High
Increased Venous Pressure Under Development 17 90.32 High High
Sepsis 54 90.24 High High
Arrhythmias 2 Under Development 21 88.92 High High
Cv General 3 Under Development 25 86.88 High High
Diabetes Mellitus 21 86.64 High High
Hyperglycemia 183 86.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After cessation of CPB, the remaining blood left in the CPB circuit was centrifuged for 5 min at 3000 rpm, and the supernatant discarded.
Gene_expression (cessation) of CPB in blood
1) Confidence 0.58 Published 2008 Journal J Cardiothorac Surg Section Body Doc Link PMC2553064 Disease Relevance 0.08 Pain Relevance 0
A significant amount of enkephalin immunoreactivity (178-185 fmol/mg protein) was observed upon trypsin and carboxypeptidase B digestion of fibroblast cell extracts, whereas only 3-5% of this amount was free enkephalin.
Gene_expression (observed) of carboxypeptidase B in fibroblast associated with enkephalin
2) Confidence 0.24 Published 1990 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 1698363 Disease Relevance 0 Pain Relevance 0.37
We demonstrated the link between CPB duration and the MMP-9 concentration.
Gene_expression (duration) of CPB
3) Confidence 0.20 Published 2009 Journal Prz. Lek. Section Abstract Doc Link 20043576 Disease Relevance 0.17 Pain Relevance 0.15
Enkephalin convertase (EC 3.4.17.10), a carboxypeptidase B-like enzyme detected by [3H]guanidinoethylmercaptosuccinic acid (GEMSA) autoradiography, is present in high concentration throughout the brains of rat fetuses 3 days prior to birth.
Gene_expression (present) of carboxypeptidase B-like in brains associated with enkephalin
4) Confidence 0.13 Published 1986 Journal Brain Res. Section Abstract Doc Link 3021286 Disease Relevance 0 Pain Relevance 0.44
Enkephalin convertase (EC 3.4.17.10), a carboxypeptidase B-like enzyme detected by [3H]guanidinoethylmercaptosuccinic acid (GEMSA) autoradiography, is present in high concentration throughout the brains of rat fetuses 3 days prior to birth.
Gene_expression (detected) of carboxypeptidase B-like in brains associated with enkephalin
5) Confidence 0.13 Published 1986 Journal Brain Res. Section Abstract Doc Link 3021286 Disease Relevance 0 Pain Relevance 0.40
However, no cutoff value could be detected for the lowest Do2 during CPB; conversely, cutoff values of 96 minutes for CPB duration (sensitivity 74%, specificity 80%) and of 160 mg/dl for peak blood glucose on CPB (sensitivity 84%, specificity 83%) were found.
Gene_expression (duration) of CPB in blood
6) Confidence 0.08 Published 2006 Journal Crit Care Section Body Doc Link PMC1794481 Disease Relevance 0.42 Pain Relevance 0
The univariate model was then corrected for the other covariates determining the peak blood lactate value (preoperative serum creatinine value, presence of active endocarditis, and CPB duration).
Gene_expression (duration) of CPB in blood associated with cv unclassified under development
7) Confidence 0.08 Published 2006 Journal Crit Care Section Body Doc Link PMC1794481 Disease Relevance 0.74 Pain Relevance 0
The patient population was arranged in order of increasing peak blood glucose levels, lowest Do2, and CPB duration, and a total of 37 subgroups (75% overlapping ranges) were analyzed with respect to the HL incidence.
Gene_expression (duration) of CPB in blood
8) Confidence 0.08 Published 2006 Journal Crit Care Section Body Doc Link PMC1794481 Disease Relevance 0 Pain Relevance 0
At the onset of CPB and every 20 minutes, an arterial blood gas analysis, including blood glucose (mg/dl) and lactate (mmol/l) determination, was obtained.
Gene_expression (onset) of CPB in blood
9) Confidence 0.08 Published 2006 Journal Crit Care Section Body Doc Link PMC1794481 Disease Relevance 0.78 Pain Relevance 0.08
However, no cutoff value could be detected for the lowest Do2 during CPB; conversely, cutoff values of 96 minutes for CPB duration (sensitivity 74%, specificity 80%) and of 160 mg/dl for peak blood glucose on CPB (sensitivity 84%, specificity 83%) were found.
Gene_expression (detected) of CPB in blood
10) Confidence 0.08 Published 2006 Journal Crit Care Section Body Doc Link PMC1794481 Disease Relevance 0.51 Pain Relevance 0
Some of these factors were confirmed in our study, and other new factors were identified; however, our study population had a significantly shorter CPB duration and a lower degree of hemodilution during CPB.
Gene_expression (duration) of CPB
11) Confidence 0.08 Published 2006 Journal Crit Care Section Body Doc Link PMC1794481 Disease Relevance 0.49 Pain Relevance 0
Anesthesia, surgery, and CPB management
Gene_expression (management) of CPB associated with anesthesia
12) Confidence 0.08 Published 2006 Journal Crit Care Section Body Doc Link PMC1794481 Disease Relevance 0.09 Pain Relevance 0.50
In fact, the association between CPB duration and peak blood lactate level is not linear: we could identify a cutoff value of 96 minutes as predictive of HL during CPB.
Gene_expression (duration) of CPB in blood
13) Confidence 0.08 Published 2006 Journal Crit Care Section Body Doc Link PMC1794481 Disease Relevance 0.37 Pain Relevance 0
The measurement of the Svo2 is possible during CPB, but very rarely is it routinely performed using on-line measurement devices in adult patients.
Spec (possible) Gene_expression (possible) of CPB
14) Confidence 0.08 Published 2006 Journal Crit Care Section Body Doc Link PMC1794481 Disease Relevance 0.41 Pain Relevance 0
There are no previous studies addressing Do2 and lactate levels during CPB.
Gene_expression (addressing) of CPB
15) Confidence 0.08 Published 2006 Journal Crit Care Section Body Doc Link PMC1794481 Disease Relevance 0.06 Pain Relevance 0
The following data were collected from the Institutional Database or direct analysis of the perfusion files: demographics: age (months), weight (kg), gender; type of surgical operation with Aristotle complexity score [16]; preoperative laboratory data: hematocrit (percentage), platelet count (cells/microliter), prothrombin time (seconds), activated partial thromboplastin time (seconds), antithrombin (percentage), serum creatinine value (milligrams per deciliter); CPB data: CPB duration (minutes), lowest temperature on CPB (degrees Centigrade), use of blood prime, ScVO2 values (percentage), and lactate values (mmol/L).
Gene_expression (duration) of CPB in blood
16) Confidence 0.05 Published 2010 Journal Crit Care Section Body Doc Link PMC2945132 Disease Relevance 0 Pain Relevance 0
Other factors associated with major morbidity and mortality in a univariate logistic regression analysis were age, weight, Aristotle score, serum creatinine value, CPB duration, and lowest temperature on CPB.
Gene_expression (duration) of CPB
17) Confidence 0.05 Published 2010 Journal Crit Care Section Body Doc Link PMC2945132 Disease Relevance 0 Pain Relevance 0
This association is graphically presented in Figures 2 and 3, for a CPB duration settled at 90 minutes.
Gene_expression (duration) of CPB
18) Confidence 0.05 Published 2010 Journal Crit Care Section Body Doc Link PMC2945132 Disease Relevance 0 Pain Relevance 0
The following data were collected from the Institutional Database or direct analysis of the perfusion files: demographics: age (months), weight (kg), gender; type of surgical operation with Aristotle complexity score [16]; preoperative laboratory data: hematocrit (percentage), platelet count (cells/microliter), prothrombin time (seconds), activated partial thromboplastin time (seconds), antithrombin (percentage), serum creatinine value (milligrams per deciliter); CPB data: CPB duration (minutes), lowest temperature on CPB (degrees Centigrade), use of blood prime, ScVO2 values (percentage), and lactate values (mmol/L).
Gene_expression (data) of CPB in blood
19) Confidence 0.05 Published 2010 Journal Crit Care Section Body Doc Link PMC2945132 Disease Relevance 0 Pain Relevance 0
The following data were collected from the Institutional Database or direct analysis of the perfusion files: demographics: age (months), weight (kg), gender; type of surgical operation with Aristotle complexity score [16]; preoperative laboratory data: hematocrit (percentage), platelet count (cells/microliter), prothrombin time (seconds), activated partial thromboplastin time (seconds), antithrombin (percentage), serum creatinine value (milligrams per deciliter); CPB data: CPB duration (minutes), lowest temperature on CPB (degrees Centigrade), use of blood prime, ScVO2 values (percentage), and lactate values (mmol/L).
Gene_expression (duration) of CPB in blood
20) Confidence 0.05 Published 2010 Journal Crit Care Section Body Doc Link PMC2945132 Disease Relevance 0 Pain Relevance 0

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