INT145860

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.52
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igfbp3) extracellular region (Igfbp3) nucleus (Igfbp3)
Igfbp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Snapping jaw 3 90.04 High High
backache 1 14.48 Low Low
Pain 1 13.08 Low Low
cva 7 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 8 97.88 Very High Very High Very High
Temporomandibular Joint Syndrome 3 90.04 High High
Breast Cancer 49 80.16 Quite High
Endometriosis (extended) 13 74.40 Quite High
INFLAMMATION 1 67.64 Quite High
Endometrial Cancer 2 60.44 Quite High
Reprotox - General 2 1 51.48 Quite High
Reprotox - General 1 3 50.16 Quite High
Ovarian Cysts 3 36.68 Quite Low
Thrombosis 2 21.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The gene expression of IGF1, IGF2, IGF1R, IRS1, IGFBP3, and IGFBP5 was significantly (p < 0.05) inhibited when cells were subjected to continuous biophysical strain, as compared to control at both time points.
Negative_regulation (inhibited) of Gene_expression (expression) of IGFBP3 associated with sprains and strains
1) Confidence 0.35 Published 2007 Journal Ann. Anat. Section Abstract Doc Link 17695985 Disease Relevance 1.01 Pain Relevance 0.27
4.6%) (Kimler et al. 2006)IGF-1: IGFBP-3 ratio was significantly reduced (P=0.001) (Fabian et al. 2006).
Negative_regulation (reduced) of Gene_expression (ratio) of IGFBP-3
2) Confidence 0.13 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012444 Disease Relevance 0.51 Pain Relevance 0

General Comments

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