INT145864

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Context Info
Confidence 0.71
First Reported 2004
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.34
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Irs1) plasma membrane (Irs1) nucleus (Irs1)
cytoplasm (Irs1) signal transducer activity (Irs1)
Anatomy Link Frequency
skeletal muscle 2
chromaffin cells 1
TMJ 1
Irs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
corticosteroid 48 99.40 Very High Very High Very High
Catecholamine 1 97.82 Very High Very High Very High
Calcium channel 1 97.32 Very High Very High Very High
sodium channel 1 96.42 Very High Very High Very High
Snapping jaw 6 96.28 Very High Very High Very High
Nav1.7 1 96.12 Very High Very High Very High
ischemia 1 84.04 Quite High
Inflammation 7 81.44 Quite High
dexamethasone 10 77.40 Quite High
Antinociceptive 4 37.72 Quite Low
Disease Link Frequency Relevance Heat
Sprains And Strains 16 99.60 Very High Very High Very High
Insulin Resistance 52 98.60 Very High Very High Very High
Temporomandibular Joint Syndrome 6 96.28 Very High Very High Very High
Diabetes Mellitus 123 94.84 High High
INFLAMMATION 9 86.08 High High
Cv Unclassified Under Development 1 84.04 Quite High
Neurodegenerative Disease 1 83.64 Quite High
Disease 4 75.72 Quite High
Attention Deficit Hyperactivity Disorder 1 73.92 Quite High
Neuropathic Pain 2 60.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The gene expression of IGF1, IGF2, IGF1R, IRS1, IGFBP3, and IGFBP5 was significantly (p < 0.05) inhibited when cells were subjected to continuous biophysical strain, as compared to control at both time points.
Gene_expression (expression) of IRS1 associated with sprains and strains
1) Confidence 0.71 Published 2007 Journal Ann. Anat. Section Abstract Doc Link 17695985 Disease Relevance 0.99 Pain Relevance 0.27
The objective of this in vitro study was to determine if continuous biophysical strain regulates the gene expression of IGF1, IGF2, IGF1 receptor (IGF1R), insulin receptor substrate (IRS1), and IGF-binding proteins (IGFBP) 3 and 5 in cells from the fibrocartilaginous disc of the temporomandibular joint (TMJ).
Gene_expression (expression) of IRS1 in TMJ associated with snapping jaw and sprains and strains
2) Confidence 0.71 Published 2007 Journal Ann. Anat. Section Abstract Doc Link 17695985 Disease Relevance 0.83 Pain Relevance 0.28
Previous studies have suggested that IRS-1 plays a central role in the glucose transport in skeletal muscle and that decreased expression of the IRS-1 protein is involved in the development of insulin resistance (40–43).
Gene_expression (expression) of IRS-1 protein in skeletal muscle associated with insulin resistance
3) Confidence 0.59 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.49 Pain Relevance 0
We also determined the upstream of IRS-1 in the insulin-signaling pathway: the protein content of IR-?
Spec (determined) Gene_expression (upstream) of IRS-1
4) Confidence 0.51 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.47 Pain Relevance 0
It has been reported that chronic CS treatment down-regulates the expression of IRS-1 in skeletal muscle (Giorgino et al. 1993).
Gene_expression (expression) of IRS-1 in skeletal muscle associated with corticosteroid
5) Confidence 0.49 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0.13
The proposed PK/PD model reasonably captured the down-regulation of IRS-1 message by MPL administration (Fig. 8).
Gene_expression (message) of IRS-1
6) Confidence 0.42 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0
In adrenal chromaffin cells, GSK-3 inhibition caused up-regulation of voltage-dependent Nav1.7 sodium channel, enhancing voltage-dependent calcium channel gating and catecholamine exocytosis; conversely, chronic treatment with GSK-3 inhibitors caused down-regulation of insulin receptor, IRS-1, IRS-2, and Akt1 levels.
Gene_expression (levels) of IRS-1 in chromaffin cells associated with catecholamine, calcium channel, sodium channel and nav1.7
7) Confidence 0.03 Published 2009 Journal Front. Biosci. Section Abstract Doc Link 19273146 Disease Relevance 0.55 Pain Relevance 0.32

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