INT145873

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 3.44
Pain Relevance 3.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm2) plasma membrane (Grm2) intracellular (Grm2)
signal transducer activity (Grm2)
Anatomy Link Frequency
dorsal root ganglion 5
neurons 2
spinal cord 1
Grm2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 80 100.00 Very High Very High Very High
dorsal root ganglion 9 100.00 Very High Very High Very High
Glutamate receptor 2 100.00 Very High Very High Very High
Glutamate 2 100.00 Very High Very High Very High
Antihyperalgesic 8 98.16 Very High Very High Very High
analgesia 5 96.04 Very High Very High Very High
Hyperalgesia 34 94.16 High High
antagonist 1 93.52 High High
Pain 34 91.12 High High
Dorsal horn 3 89.48 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 9 100.00 Very High Very High Very High
Hyperalgesia 62 94.16 High High
Hypersensitivity 26 94.00 High High
Nociception 37 93.32 High High
Pain 57 91.12 High High
Attention Deficit Hyperactivity Disorder 2 87.84 High High
Neuropathic Pain 11 79.00 Quite High
Inflammatory Pain 14 76.64 Quite High
Injury 1 69.40 Quite High
Peripheral Neuropathy 1 60.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, recently, the expression of the metabotropic glutamate receptor 2 gene in the spinal cord and dorsal root ganglion was found to be upregulated after systemic administration of MS-275 or SAHA, and this upregulation likely mediates the inhibitory effect of these HDACIs on formalin-induced hyperalgesia [27].
Positive_regulation (upregulated) of Gene_expression (expression) of metabotropic glutamate receptor 2 gene in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, hyperalgesia, glutamate receptor and spinal cord
1) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942827 Disease Relevance 1.03 Pain Relevance 0.88
For example, recently, the expression of the metabotropic glutamate receptor 2 gene in the spinal cord and dorsal root ganglion was found to be upregulated after systemic administration of MS-275 or SAHA, and this upregulation likely mediates the inhibitory effect of these HDACIs on formalin-induced hyperalgesia [27].
Positive_regulation (upregulated) of in spinal cord Gene_expression (expression) of metabotropic glutamate receptor 2 gene in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, hyperalgesia, glutamate receptor and spinal cord
2) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942827 Disease Relevance 1.03 Pain Relevance 0.88
Both MS-275 and SAHA up-regulated the expression of mGlu2 receptors in the dorsal root ganglion (DRG) and spinal cord under conditions in which they caused analgesia, without changing the expression of mGlu1a, mGlu4, or mGlu5 receptors.
Positive_regulation (up-regulated) of Gene_expression (expression) of mGlu2 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, analgesia and spinal cord
3) Confidence 0.00 Published 2009 Journal Mol. Pharmacol. Section Abstract Doc Link 19255242 Disease Relevance 0.63 Pain Relevance 0.85
These processes involve the activation of muscarinic cholinergic receptors in the forebrain, and an increased expression of type-2 metabotropic glutamate (mGlu2) receptors in dorsal root ganglia neurons.
Positive_regulation (increased) of Gene_expression (expression) of mGlu2 in neurons associated with glutamate
4) Confidence 0.00 Published 2007 Journal CNS Drugs Section Abstract Doc Link 17696591 Disease Relevance 0.76 Pain Relevance 0.84

General Comments

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