INT145874

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Context Info
Confidence 0.12
First Reported 2006
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.24
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm2) plasma membrane (Grm2) intracellular (Grm2)
signal transducer activity (Grm2)
Anatomy Link Frequency
neuronal 2
Grm2 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 18 99.54 Very High Very High Very High
hyperexcitability 1 96.28 Very High Very High Very High
Neurotransmitter 7 96.24 Very High Very High Very High
Pain 14 86.96 High High
Glutamate receptor 18 84.60 Quite High
analgesia 15 82.60 Quite High
Lamotrigine 4 77.36 Quite High
Neuropathic pain 14 75.00 Quite High
Antinociceptive 2 73.20 Quite High
sSRI 34 70.96 Quite High
Disease Link Frequency Relevance Heat
Pain 16 86.96 High High
Anxiety Disorder 209 81.36 Quite High
Neuropathic Pain 15 75.00 Quite High
Injury 1 65.24 Quite High
Manic Depressive Disorder 3 63.00 Quite High
Epilepsy 2 62.16 Quite High
Peripheral Neuropathy 1 56.48 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 55.20 Quite High
Diabetes Mellitus 1 54.88 Quite High
Obsessive-compulsive Disorder 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given that in addition to its role in fatty acid metabolism LAC also behaves as a donor of acetyl groups for amino acids and proteins [24], we examined whether LAC-induced mGlu2 upregulation is mediated by the NF-?
Spec (whether) Positive_regulation (mediated) of Spec (whether) Positive_regulation (upregulation) of mGlu2
1) Confidence 0.12 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0 Pain Relevance 0
Given that in addition to its role in fatty acid metabolism LAC also behaves as a donor of acetyl groups for amino acids and proteins [24], we examined whether LAC-induced mGlu2 upregulation is mediated by the NF-?
Spec (whether) Positive_regulation (induced) of Spec (whether) Positive_regulation (upregulation) of mGlu2
2) Confidence 0.12 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0 Pain Relevance 0
Importantly, excessive neuronal activity leading to glutamate spillover seems to be required for activation of mGluR2, suggesting that its function may be to protect against pathological bouts of glutamatergic hyperexcitability [144].
Positive_regulation (required) of Positive_regulation (activation) of mGluR2 in neuronal associated with glutamate and hyperexcitability
3) Confidence 0.02 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.53 Pain Relevance 0.52
Induction of mGlu2 receptors is mediated by acetylation mechanisms that involve transcription factors of the nuclear factor (NF)-kappaB family.
Positive_regulation (mediated) of Positive_regulation (Induction) of mGlu2
4) Confidence 0.00 Published 2007 Journal CNS Drugs Section Abstract Doc Link 17696591 Disease Relevance 0.72 Pain Relevance 0.80

General Comments

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