INT145878

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.30
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.20
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Pgp)
Anatomy Link Frequency
capillary 2
Pgp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 7 99.40 Very High Very High Very High
Analgesic 1 98.32 Very High Very High Very High
opiate 1 97.92 Very High Very High Very High
IPN 6 93.16 High High
antinociception 1 83.60 Quite High
Hyperalgesia 2 81.84 Quite High
Inflammation 4 81.32 Quite High
analgesia 1 79.60 Quite High
Inflammatory mediators 1 75.88 Quite High
Serotonin 5 72.40 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Pain 6 93.16 High High
Hyperalgesia 2 81.84 Quite High
INFLAMMATION 5 81.32 Quite High
Epilepsy 1 73.84 Quite High
Brain Disease 1 73.12 Quite High
Cancer 1 71.84 Quite High
Urological Neuroanatomy 4 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Coagulation Disorder 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclosporin A-mediated inhibition of Pgp enhanced the uptake of morphine in lambda-carrageenan and control animals.
Positive_regulation (enhanced) of Negative_regulation (inhibition) of Pgp associated with morphine
1) Confidence 0.30 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17697052 Disease Relevance 1.20 Pain Relevance 1.66
Specifically, it was shown in vitro that fluvoxamine induces intermediate Pgp inhibition in MDR1 cells (model for human Pgp) as well as in primary porcine brain capillary endothelial cells (model for the BBB) (15), although this could not be confirmed in another study in MDR-1 cells (16).
Positive_regulation (induces) of Negative_regulation (inhibition) of Pgp in capillary
2) Confidence 0.28 Published 2007 Journal Pharm Res Section Body Doc Link PMC2279155 Disease Relevance 0 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox