INT145879

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Context Info
Confidence 0.30
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.23
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Pgp)
Anatomy Link Frequency
capillary 2
brain 2
Pgp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
IPN 6 99.60 Very High Very High Very High
Hyperalgesia 2 90.16 High High
opiate 1 89.92 High High
Inflammation 4 89.64 High High
Analgesic 1 89.36 High High
Morphine 7 87.92 High High
Inflammatory mediators 1 84.20 Quite High
Serotonin 5 72.40 Quite High
antinociception 1 66.80 Quite High
analgesia 1 62.80 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Pain 6 99.60 Very High Very High Very High
Hyperalgesia 2 90.16 High High
INFLAMMATION 5 89.64 High High
Epilepsy 1 82.16 Quite High
Brain Disease 1 81.44 Quite High
Cancer 1 80.16 Quite High
Urological Neuroanatomy 4 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Coagulation Disorder 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis of enriched brain microvessel fractions showed increased Pgp expression 3 h post-CIP.
Positive_regulation (increased) of Gene_expression (expression) of Pgp in brain associated with ipn
1) Confidence 0.30 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17697052 Disease Relevance 1.23 Pain Relevance 1.54
Specifically, it was shown in vitro that fluvoxamine induces intermediate Pgp inhibition in MDR1 cells (model for human Pgp) as well as in primary porcine brain capillary endothelial cells (model for the BBB) (15), although this could not be confirmed in another study in MDR-1 cells (16).
Positive_regulation (induces) of Neg (inhibition) Gene_expression (inhibition) of Pgp in capillary
2) Confidence 0.30 Published 2007 Journal Pharm Res Section Body Doc Link PMC2279155 Disease Relevance 0 Pain Relevance 0.09

General Comments

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