INT145888

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 27
Total Number 27
Disease Relevance 8.98
Pain Relevance 5.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mthfd1) oxidoreductase activity (Mthfd1) ligase activity (Mthfd1)
cytoplasm (Mthfd1)
Anatomy Link Frequency
macrophages 2
bone marrow 2
T cell 2
blood 1
monocyte 1
Mthfd1 (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 369 100.00 Very High Very High Very High
Central nervous system 296 100.00 Very High Very High Very High
Inflammatory response 24 99.24 Very High Very High Very High
ischemia 26 98.36 Very High Very High Very High
Inflammation 317 98.12 Very High Very High Very High
cytokine 198 96.24 Very High Very High Very High
metalloproteinase 4 95.12 Very High Very High Very High
transdermal 1 92.00 High High
Multiple sclerosis 320 91.68 High High
cINOD 138 88.20 High High
Disease Link Frequency Relevance Heat
Disease 269 99.68 Very High Very High Very High
Central Nervous System Disease 54 99.68 Very High Very High Very High
Injury 177 99.32 Very High Very High Very High
Emphysema 20 99.00 Very High Very High Very High
Recurrence 20 98.88 Very High Very High Very High
INFLAMMATION 357 98.84 Very High Very High Very High
Autoimmune Disease 145 98.84 Very High Very High Very High
Infection 189 98.76 Very High Very High Very High
Coronary Artery Disease 11 98.68 Very High Very High Very High
Cv Unclassified Under Development 26 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intriguingly, IL-10 production was enhanced in TLR4-deficient BMDCs, but completely abolished in TLR2-/- BMDCs.
Negative_regulation (abolished) of DCs
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877707 Disease Relevance 0.11 Pain Relevance 0
Stimulation of both left and right DLPFC with active, but not sham, tDCS reduced craving significantly when comparing craving at baseline and after stimulation, without (p = .007) and with (p = .005) smoking-craving cues.
Negative_regulation (reduced) of tDCS
2) Confidence 0.21 Published 2008 Journal J Clin Psychiatry Section Body Doc Link 18312035 Disease Relevance 0.08 Pain Relevance 0
Lower numbers of macrophages and DCs, combined with impaired release of MMP-12, also resulted in an attenuation of CS-induced pulmonary emphysema in NK1-R-/- mice.
Negative_regulation (numbers) of DCs in macrophages associated with pulmonary emphysema
3) Confidence 0.14 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 1.20 Pain Relevance 0.25
The lower numbers of both macrophages and DCs in CS-exposed NK1-R-/- mice should thus result in a diminished release of MMP-12 in these mice.
Negative_regulation (numbers) of DCs in macrophages
4) Confidence 0.14 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 0.51 Pain Relevance 0.21
In the intestinal PP, a third subset of CD11c+ DCs distinct from lymphoid and myeloid phenotypes, has been characterized which does not express either high levels of CD11b or CD8?
Negative_regulation (subset) of DCs
5) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776531 Disease Relevance 0 Pain Relevance 0.04
Following kidney ischemia-perfusion, resident dentritic cells release TNF, IL-6, MCP-1, and RANTES and the depletion of DCs before ischemic injury significantly reduces TNF levels in the kidney [131].
Negative_regulation (depletion) of DCs in kidney associated with ischemia and injury
6) Confidence 0.12 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.65 Pain Relevance 0.15
However, the number of MLN CXCR3+ plasmacytoid DCs was significantly higher in mycobacterial-challenged mice than in other groups of mice.
Negative_regulation (number) of DCs
7) Confidence 0.09 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.60 Pain Relevance 0.07
The number of PP CXCR3+ DCs was significantly higher in live Mycobacteria-challenged mice than in other groups (Figure 5B).
Negative_regulation (number) of DCs
8) Confidence 0.09 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.56 Pain Relevance 0.07
The absolute number of peripheral-blood DCs was significantly higher in the CAD group compared with the control group (p = 0.04).
Negative_regulation (number) of DCs in blood associated with coronary artery disease
9) Confidence 0.09 Published 2007 Journal Am. J. Cardiol. Section Abstract Doc Link 17697812 Disease Relevance 0.79 Pain Relevance 0.09
The relative functional preservation of CTL in the CNS could be attributed to the low number of DCs in this compartment during the acute phase of clone 13 persistence (Fig. 7C).
Negative_regulation (number) of DCs associated with central nervous system
10) Confidence 0.09 Published 2007 Journal Virol J Section Body Doc Link PMC1899484 Disease Relevance 0 Pain Relevance 0.37
A reduced number of CNS DCs could potentially expose CTL to a less immunosuppressive milieu.
Negative_regulation (number) of DCs associated with central nervous system
11) Confidence 0.09 Published 2007 Journal Virol J Section Body Doc Link PMC1899484 Disease Relevance 0 Pain Relevance 0.40
In addition, tDCS/TENS induced greater pain reduction than tDCS (P=0.02).
Negative_regulation (reduction) of tDCS
12) Confidence 0.09 Published 2009 Journal Clin J Pain Section Body Doc Link 19920718 Disease Relevance 0.06 Pain Relevance 0
Thereby antigens may be able to approach the LCs in the epidermis and the DCs in the dermis (13).
Negative_regulation (approach) of DCs in dermis
13) Confidence 0.08 Published 2009 Journal Pharm Res Section Body Doc Link PMC2689355 Disease Relevance 0.34 Pain Relevance 0.20
The protective effect of untreated or LAB-pulsed DCs was studied by intra-peritoneal administration of 2×106 cells, 2 h before TNBS-colitis induction.
Negative_regulation (effect) of DCs associated with colitis
14) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819555 Disease Relevance 0.64 Pain Relevance 0.14
In addition, we showed that the DCs generated in the presence of these drugs are profoundly suppressed in MHC-restricted antigen presentation capability.
Negative_regulation (suppressed) of DCs
15) Confidence 0.08 Published 2010 Journal Immune Network Section Body Doc Link PMC2902675 Disease Relevance 0.09 Pain Relevance 0.14
In addition, miR-155 downregulated expression of DC-specific ICAM3-grabbing nonintegrin (DC-SIGN; also known as CD209) by human monocyte-derived DCs through suppression of PU.1 expression [138].
Negative_regulation (155 downregul) of DCs in monocyte
16) Confidence 0.07 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.11 Pain Relevance 0.04
Depletion of pDCs during either the acute or relapse phase of EAE resulted in exacerbation of disease severity [163].
Negative_regulation (Depletion) of pDCs associated with multiple sclerosis, disease and recurrence
17) Confidence 0.07 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 1.46 Pain Relevance 0.33
Although ibuprofen slightly increased the expression of co-stimulatory molecules as well as MHC molecules, the DCs treated with ibuprofen were suppressed in activating OVA-specific CD4 T cells compared to normal DCs.
Negative_regulation (suppressed) of DCs in T cells
18) Confidence 0.06 Published 2010 Journal Immune Network Section Body Doc Link PMC2902675 Disease Relevance 0 Pain Relevance 0.11
Our results show that DCs generated from mouse bone marrow cells in the presence of aspirin (100µM) or ibuprofen (100µM) from the early stage of differentiation (Day 0 or 3 after the differentiation initiation culture) were profoundly suppressed in MHC-restricted exogenous antigen presenting capability.
Negative_regulation (suppressed) of DCs in bone marrow associated with aspirin
19) Confidence 0.06 Published 2010 Journal Immune Network Section Body Doc Link PMC2902675 Disease Relevance 0.26 Pain Relevance 0.48
The present study demonstrates that DCs exposed to aspirin or ibuprofen for 18 h are suppressed in MHC-restricted exogenous antigen presenting capability.
Negative_regulation (suppressed) of DCs associated with aspirin
20) Confidence 0.06 Published 2010 Journal Immune Network Section Body Doc Link PMC2902675 Disease Relevance 0.06 Pain Relevance 0.33

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