INT1459

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Context Info
Confidence 0.67
First Reported 1978
Last Reported 2004
Negated 1
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 0.08
Pain Relevance 10.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
thalamus 3
hypothalamus 2
substantia nigra pars reticulata 2
brain 2
striatum 2
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 76 100.00 Very High Very High Very High
narcan 29 100.00 Very High Very High Very High
Morphine 7 99.28 Very High Very High Very High
Substantia nigra 1 99.16 Very High Very High Very High
Thalamus 9 98.92 Very High Very High Very High
midbrain 9 98.72 Very High Very High Very High
cerebral cortex 2 97.52 Very High Very High Very High
agonist 2 94.04 High High
opiate 12 93.68 High High
opioid receptor 9 93.20 High High
Disease Link Frequency Relevance Heat
Alcohol Addiction 1 75.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significant increase in [(3)H] (2-D-penicillamine, 5-D-penicillamine)-enkephalin binding was observed in the substantia nigra pars reticulata 1 h after ethanol treatment.
Positive_regulation (increase) of enkephalin Binding (binding) of in substantia nigra pars reticulata associated with substantia nigra and enkephalin
1) Confidence 0.67 Published 2004 Journal Brain Res. Section Abstract Doc Link 15527743 Disease Relevance 0.08 Pain Relevance 0.66
In the hypothalamus, specific ENK binding was increased without any change in NAL binding.
Positive_regulation (increased) of ENK Binding (binding) of in hypothalamus associated with narcan and enkephalin
2) Confidence 0.67 Published 1990 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 1965518 Disease Relevance 0 Pain Relevance 1.04
Castration itself produced an increase in specific NAL and ENK binding in the olfactory bulb and thalamus + midbrain.
Positive_regulation (increase) of ENK Binding (binding) of in thalamus associated with narcan, midbrain, thalamus and enkephalin
3) Confidence 0.67 Published 1990 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 1965518 Disease Relevance 0 Pain Relevance 1.02
At 26 degrees C, 0.1--1.0 mM manganese but not magnesium or calcium increases the binding of 3H-methionine enkephalin, while at 0 degrees C manganese decreases the binding of methionine enkephalin.
Neg (not) Positive_regulation (increases) of enkephalin Binding (binding) of associated with enkephalin
4) Confidence 0.58 Published 1978 Journal Eur. J. Pharmacol. Section Abstract Doc Link 204498 Disease Relevance 0 Pain Relevance 1.55
In the absence of sodium, however, guanine nucleotides only slightly lowered the ENK binding at 25 degrees C, and at 0 degree C they strongly increased the ENK binding dose-dependently.
Positive_regulation (increased) of ENK Binding (binding) of associated with enkephalin
5) Confidence 0.50 Published 1985 Journal Peptides Section Abstract Doc Link 2995942 Disease Relevance 0 Pain Relevance 0.95
In the absence of sodium at 0 degree C, cupric ions completely antagonized the nucleotide-induced increase in the ENK binding, although zinc ions did not affect it.
Positive_regulation (increase) of ENK Binding (binding) of associated with enkephalin
6) Confidence 0.50 Published 1985 Journal Peptides Section Abstract Doc Link 2995942 Disease Relevance 0 Pain Relevance 0.92
A specific method is presented for the assay of leucine-enkephalin (Leu-Enk) and its metabolites by reversed-phase high-performance liquid chromatography on a muBondapak C18 column with a mobile phase of methanol-water and 0.005 M tetrabutylammonium phosphate.
Positive_regulation (presented) of leucine-enkephalin Binding (assay) of associated with enkephalin
7) Confidence 0.49 Published 1982 Journal J. Chromatogr. Section Abstract Doc Link 7161327 Disease Relevance 0 Pain Relevance 0.17
Pretreatment of rat brain membranes at pH 4.5 increased GTP and Gpp(NH)p regulation of [3H]-D-ala2-met5-enkephalinamide (D-ala-enk) binding with no change in absolute binding itself.
Positive_regulation (increased) of enk Binding (binding) of in brain
8) Confidence 0.49 Published 1983 Journal Life Sci. Section Abstract Doc Link 6319864 Disease Relevance 0 Pain Relevance 0.11
Scatchard plots of saturation experiments indicate that the increase of ENK binding is due to the increased affinity of the binding sites, and the increase of TRH binding reflects an increase in numbers of binding sites.
Positive_regulation (increase) of ENK Binding (binding) of associated with enkephalin
9) Confidence 0.49 Published 1984 Journal Peptides Section Abstract Doc Link 6324150 Disease Relevance 0 Pain Relevance 0.73
On the other hand, the potencies of morphine and nalorphine against [3H]leucine enkephalin binding were considerably enhanced by the conjugations at the 6-position, whereas the potencies against [3H]morphine binding were decreased.
Positive_regulation (enhanced) of enkephalin Binding (binding) of associated with enkephalin and morphine
10) Confidence 0.45 Published 1987 Journal Life Sci. Section Abstract Doc Link 3041142 Disease Relevance 0 Pain Relevance 0.88
The enkephalin binding in the striatum appears later in embryonic development and gradually increases in density to form the rather homogeneous adult pattern.
Positive_regulation (increases) of enkephalin Binding (binding) of in striatum associated with enkephalin
11) Confidence 0.45 Published 1981 Journal Brain Res. Section Abstract Doc Link 6272946 Disease Relevance 0 Pain Relevance 0.72
A specific method is presented for the assay of leucine-enkephalin (Leu-Enk) and its metabolites by reversed-phase high-performance liquid chromatography on a muBondapak C18 column with a mobile phase of methanol-water and 0.005 M tetrabutylammonium phosphate.
Positive_regulation (presented) of Leu-Enk Binding (assay) of associated with enkephalin
12) Confidence 0.43 Published 1982 Journal J. Chromatogr. Section Abstract Doc Link 7161327 Disease Relevance 0 Pain Relevance 0.17
The binding of Leu-enkephalin (Leu-Enk) to rat striatal synaptosomal membranes is enhanced when the enkephalinase activity or the aminopeptidase activity present in these membranes is inhibited.
Positive_regulation (enhanced) of Leu-enkephalin Binding (binding) of associated with enkephalin
13) Confidence 0.33 Published 1982 Journal Adv. Biochem. Psychopharmacol. Section Abstract Doc Link 6751033 Disease Relevance 0 Pain Relevance 0.51
Castration itself produced an increase in specific NAL and ENK binding in the olfactory bulb and thalamus + midbrain.
Positive_regulation (increase) of ENK in olfactory bulb Binding (binding) of in thalamus associated with narcan, midbrain, thalamus and enkephalin
14) Confidence 0.23 Published 1990 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 1965518 Disease Relevance 0 Pain Relevance 1.02
Two binding sites for BETA are present adjacent to the promoter of the rat proenkephalin gene.
Positive_regulation (present) of proenkephalin gene Binding (binding) of
15) Confidence 0.04 Published 1989 Journal Neuron Section Abstract Doc Link 2701844 Disease Relevance 0 Pain Relevance 0

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