INT145904

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 5
Disease Relevance 0.94
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr2) plasma membrane (Cnr2) signal transducer activity (Cnr2)
Anatomy Link Frequency
microglial cells 4
Cnr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 24 100.00 Very High Very High Very High
opioid receptor 11 100.00 Very High Very High Very High
Endocannabinoid 1 99.96 Very High Very High Very High
agonist 90 95.68 Very High Very High Very High
Cannabinoid 46 91.60 High High
Opioid 2 81.76 Quite High
cytokine 28 79.36 Quite High
Inflammation 20 78.68 Quite High
chemokine 4 68.44 Quite High
MU agonist 1 67.92 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 28 78.68 Quite High
Dementia 4 64.48 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 16 64.12 Quite High
Multiple Sclerosis 40 63.72 Quite High
Disease 60 62.72 Quite High
Neurodegenerative Disease 16 61.32 Quite High
Targeted Disruption 10 59.88 Quite High
Necrosis 8 5.00 Very Low Very Low Very Low
Cancer 8 5.00 Very Low Very Low Very Low
Overdose 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these findings suggest that stimulation of CB2 decreases CD40 expression on primary cultured microglial cells.


Negative_regulation (decreases) of Positive_regulation (stimulation) of CB2 in microglial cells
1) Confidence 0.39 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.08
Finally, we showed that CB2 activation by JWH-015 markedly attenuated CD40-mediated inhibition of microglial phagocytosis of A?
Negative_regulation (attenuated) of Positive_regulation (activation) of CB2
2) Confidence 0.39 Published 2005 Journal J Neuroinflammation Section Abstract Doc Link PMC1352348 Disease Relevance 0.11 Pain Relevance 0.37
Stimulation of CB2 inhibits functional CD40 signaling in microglial cells
Negative_regulation (inhibits) of Positive_regulation (Stimulation) of CB2 in microglial cells
3) Confidence 0.39 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.12 Pain Relevance 0.23
We found that the selective stimulation of cannabinoid receptor CB2 by JWH-015 suppressed IFN-?
Negative_regulation (suppressed) of Positive_regulation (stimulation) of cannabinoid receptor CB2 associated with cannabinoid receptor
4) Confidence 0.34 Published 2005 Journal J Neuroinflammation Section Abstract Doc Link PMC1352348 Disease Relevance 0.59 Pain Relevance 0.50
Noladin ether, a putative endocannabinoid, inhibits mu-opioid receptor activation via CB2 cannabinoid receptors.
Negative_regulation (inhibits) of Positive_regulation (activation) of CB2 associated with endocannabinoid, cannabinoid receptor and opioid receptor
5) Confidence 0.32 Published 2008 Journal Neurochem. Int. Section Title Doc Link 17698254 Disease Relevance 0.12 Pain Relevance 0.95

General Comments

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