INT145921

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Context Info
Confidence 0.73
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.41
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL21) extracellular region (CCL21) cell-cell signaling (CCL21)
Anatomy Link Frequency
facet 1
neurons 1
skin 1
endothelium 1
CCL21 (Homo sapiens)
Pain Link Frequency Relevance Heat
hyperexcitability 2 98.24 Very High Very High Very High
rheumatoid arthritis 124 98.16 Very High Very High Very High
chemokine 48 96.56 Very High Very High Very High
Pain 7 95.72 Very High Very High Very High
spinothalamic tract 1 89.68 High High
Thalamus 3 82.80 Quite High
Dorsal horn 2 80.52 Quite High
Dorsal horn neuron 1 78.40 Quite High
Spinal cord 2 75.00 Quite High
Lasting pain 1 69.52 Quite High
Disease Link Frequency Relevance Heat
Stress 28 99.56 Very High Very High Very High
Frailty 7 99.40 Very High Very High Very High
Rheumatoid Arthritis 124 98.16 Very High Very High Very High
Nociception 2 96.36 Very High Very High Very High
Pain 6 95.72 Very High Very High Very High
INFLAMMATION 40 65.12 Quite High
Allergic Dermatitis 21 63.48 Quite High
Contact Dermatitis 23 56.24 Quite High
Injury 1 52.72 Quite High
Apoptosis 5 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the cases of IL-8, MCP-1 and SLC, their mRNAs and proteins are present in the RA synovial endothelium [50,57] indicating that such cells can both synthesise and present these chemokines.
Localization (cases) of SLC in endothelium associated with chemokine and rheumatoid arthritis
1) Confidence 0.73 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.36 Pain Relevance 0.59
A couple of years ago it was demonstrated by in vitro experiments that human LEC constitutively secrete CCL21 at their basal side [25], and more recently Weninger et al. found expression of this chemokine by LEC from normal human skin using immunofluorescence staining [13].
Localization (secrete) of CCL21 in skin associated with chemokine
2) Confidence 0.69 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 0.35 Pain Relevance 0.20
After SCI, intra-VPL antibody-mediated neutralization of CCL21 decreases microglial activation and evoked hyperexcitability of VPL neurons, and restores nociceptive thresholds to near-normal levels.
Localization (neutralization) of CCL21 in neurons associated with nociception, frailty and hyperexcitability
3) Confidence 0.63 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17699671 Disease Relevance 0.77 Pain Relevance 0.78
Besides, the predicted facet stress values after DPC and SLC insertion were larger than those after TPC insertion.
Localization (insertion) of SLC in facet associated with stress
4) Confidence 0.34 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2442839 Disease Relevance 0.94 Pain Relevance 0

General Comments

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