INT145925

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.09
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Dlx3)
Anatomy Link Frequency
colon 2
Dlx3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 5 82.08 Quite High
cINOD 5 79.72 Quite High
Pain 1 74.36 Quite High
Disease Link Frequency Relevance Heat
Cancer 1 98.96 Very High Very High Very High
Colon Cancer 6 90.84 High High
Aberrant Crypt Foci 1 86.68 High High
Apoptosis 1 86.48 High High
INFLAMMATION 5 82.08 Quite High
Pain 1 74.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of proximal and distal colon tissue from 8- and 28-week rat/azoxymethane studies showed that GT-094 treatment reduced colon crypt proliferation by 30% to 69%, reduced inducible NO synthase (iNOS) levels by 33% to 67%, reduced poly(ADP-ribose)polymerase-1 expression and cleavage 2- to 4-fold, and elevated levels of p27 in the distal colon 3-fold.
Negative_regulation (reduced) of Positive_regulation (elevated) of distal colon 3-fold in colon
1) Confidence 0.05 Published 2007 Journal Mol. Cancer Ther. Section Abstract Doc Link 17699720 Disease Relevance 1.09 Pain Relevance 0.57

General Comments

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