INT145932

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Context Info
Confidence 0.77
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.69
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Hck) plasma membrane (Hck) cytoskeleton (Hck)
nucleus (Hck) kinase activity (Hck) lysosome (Hck)
Hck (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 2 99.82 Very High Very High Very High
rheumatoid arthritis 24 89.08 High High
Arthritis 192 82.16 Quite High
spinal inflammation 8 65.96 Quite High
Inflammation 24 58.52 Quite High
fibrosis 3 43.52 Quite Low
Bioavailability 1 10.64 Low Low
cytokine 4 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Parenteral administration 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Erythrocytosis 35 99.06 Very High Very High Very High
Myelodysplastic Syndromes 62 97.82 Very High Very High Very High
Sprains And Strains 63 91.20 High High
Chondrosarcoma 2 90.88 High High
Rheumatoid Arthritis 24 89.08 High High
Reticulocytosis 5 84.40 Quite High
Immunization 32 83.52 Quite High
Arthritis 204 82.16 Quite High
Disease 26 79.80 Quite High
Leukemia 17 75.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cloning, expression, and pharmacological activity of BmK AS, an active peptide from scorpion Buthus martensii Karsch.
Gene_expression (expression) of BmK AS associated with analgesic
1) Confidence 0.77 Published 2008 Journal Biotechnol. Lett. Section Title Doc Link 17701272 Disease Relevance 0 Pain Relevance 0.18
Although Src kinases are activated by JAK2 in erythroid cells upon Epo stimulation [28] and a Src inhibitor impaired Epo-independent maturation of PV erythroid progenitors [13], we demonstrated that polycythemia induced by JAK2 V617F was independent of Lyn, Hck, and Fgr, the three principal Src family kinases expressed in myeloerythroid cells.
Gene_expression (expressed) of Hck associated with erythrocytosis and myelodysplastic syndromes
2) Confidence 0.54 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 1.18 Pain Relevance 0
DS and TK produced the recombinant proteins (hG6PI, mG6Pi and hCK) and were involved in designing the study and critically read the manuscript.



Gene_expression (produced) of hCK
3) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297579 Disease Relevance 0.88 Pain Relevance 0.50
Using the same strategy, human creatine kinase (hCK) and mouse G6PI (mG6PI) was produced.
Gene_expression (produced) of hCK
4) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297579 Disease Relevance 0.55 Pain Relevance 0.04
Several mechanisms may contribute to imatinib resistance, including increased expression of BCR-ABL kinase through gene amplification, decreased intracellular drug concentrations caused by drug efflux proteins (OCT1), clonal evolution, or over-expression of Src kinases (Lyn, Hck) involved in BCR-ABL independent activation of alternative pathways (Apperley 2007).
Gene_expression (expression) of Hck
5) Confidence 0.36 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994207 Disease Relevance 0.08 Pain Relevance 0

General Comments

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