INT145937

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Context Info
Confidence 0.39
First Reported 2003
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 32
Total Number 37
Disease Relevance 19.25
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
respiratory 2
blood 1
lung 1
PCS (Homo sapiens)
Pain Link Frequency Relevance Heat
Duloxetine 166 97.48 Very High Very High Very High
psoriasis 50 96.64 Very High Very High Very High
alcohol 27 96.24 Very High Very High Very High
depression 253 95.00 High High
Adalimumab 22 81.04 Quite High
Inflammatory marker 2 80.48 Quite High
Infliximab 24 77.04 Quite High
Pain 104 75.08 Quite High
anesthesia 5 75.00 Quite High
Etanercept 27 73.20 Quite High
Disease Link Frequency Relevance Heat
Chronic Disease 229 100.00 Very High Very High Very High
Sleep Disorders 18 100.00 Very High Very High Very High
Hypertension 202 99.72 Very High Very High Very High
Respiratory Disease 108 99.44 Very High Very High Very High
Mental Disorders 98 99.34 Very High Very High Very High
Aging 17 98.48 Very High Very High Very High
Coronary Artery Disease 121 97.76 Very High Very High Very High
Body Weight 12 97.28 Very High Very High Very High
Psoriasis 55 96.64 Very High Very High Very High
Cancer 91 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patient-controlled sedation (PCS) has been in clinical use for almost 20 years, but has not been reviewed in over 10 years.
Regulation (controlled) of PCS associated with sleep disorders
1) Confidence 0.39 Published 2008 Journal Curr Opin Anaesthesiol Section Abstract Doc Link 18997527 Disease Relevance 0.27 Pain Relevance 0
We included these variables in multivariate analyses of factors affecting the PCS score.
Spec (analyses) Regulation (affecting) of PCS
2) Confidence 0.39 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1187913 Disease Relevance 0.40 Pain Relevance 0.11
BACKGROUND: Patient controlled sedation (PCS) gives liberty to patients to choose the time of sedative administration to attain a desired level of comfort.
Regulation (controlled) of PCS associated with sleep disorders
3) Confidence 0.38 Published 2009 Journal J Postgrad Med Section Abstract Doc Link 19550055 Disease Relevance 0.17 Pain Relevance 0.07
However, patients with respiratory disease reported worse PCS than patients with other chronic disease, and the combination of cardiovascular and respiratory diseases had a negative synergistic effect on the PCS [10].
Regulation (effect) of PCS in respiratory associated with respiratory disease and chronic disease
4) Confidence 0.33 Published 2007 Journal Health Qual Life Outcomes Section Body Doc Link PMC2042974 Disease Relevance 0.72 Pain Relevance 0.09
In addition, women and men differed in how these factors influenced the PCS and MCS scores.
Regulation (influenced) of PCS
5) Confidence 0.28 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1187913 Disease Relevance 0.28 Pain Relevance 0.10
The effect of acute post-traumatic stress and neuropsychological function on acute PCS was relatively small.
Regulation (effect) of PCS
6) Confidence 0.22 Published 2008 Journal J. Neurol. Neurosurg. Psychiatr. Section Body Doc Link 17702772 Disease Relevance 0.06 Pain Relevance 0
The evidence that living alone has a protective effect on PCS in HRQL needs to be confirmed.
Regulation (effect) of PCS
7) Confidence 0.21 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2569037 Disease Relevance 0.30 Pain Relevance 0.04
Multiple logistic regression was performed using two different models to verify the influence on MCS and PCS, respectively, of socio-demographic, lifestyle, social network, geographical area and health care service access/use as independent variables; all explicatory variables were taken as models.
Regulation (influence) of PCS
8) Confidence 0.21 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2569037 Disease Relevance 0.95 Pain Relevance 0.13
Our data confirm the same synergistic effect of these systems on PCS since, in our multivariate model, cardiac problems are not significant, respiratory problems only approach significance and their interaction is highly significant i.e. their combined effect decreases more the PCS than the sum of the independent negative effect of each condition.
Regulation (effect) of PCS in respiratory
9) Confidence 0.20 Published 2007 Journal Health Qual Life Outcomes Section Body Doc Link PMC2042974 Disease Relevance 0.70 Pain Relevance 0.09
Multiple regression analyses assessed the impact of six demographic characteristics and the number of chronic diseases of pregeriatric patients on their PCS and MCS scores (Table 4).
Regulation (impact) of PCS associated with chronic disease
10) Confidence 0.20 Published 2003 Journal Health Qual Life Outcomes Section Body Doc Link PMC280701 Disease Relevance 1.37 Pain Relevance 0
History of cancer and having two or more other conditions were strongly associated with the PCS, and high ALT level, having fewer years of education, and low physical activity also had a significant effect on the PCS score.
Regulation (effect) of PCS associated with cancer
11) Confidence 0.17 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1187913 Disease Relevance 0.57 Pain Relevance 0.19
Undergoing revascularisation improved the PCS in patients, but in the younger patients and those without personal antecedents or risk factors, the PCS was affected more, perhaps due to greater expectations for recovery in these patients.



Regulation (affected) of PCS
12) Confidence 0.16 Published 2006 Journal BMC Public Health Section Abstract Doc Link PMC1413520 Disease Relevance 0.15 Pain Relevance 0
The antecedents of CHD and the presence of cardiovascular risk factors considered individually were not variables associated with the change in the PCS scores.
Regulation (change) of PCS associated with coronary artery disease
13) Confidence 0.16 Published 2006 Journal BMC Public Health Section Body Doc Link PMC1413520 Disease Relevance 0.38 Pain Relevance 0
The effect of self-reported health problems and of the physicians' reported diagnosis on the EQ-5D dimensions was estimated using logistic regression while the effect of the same variables on the EQ-5D index, EQ-self rated index, EQ-VAS, PCS-12 and MCS-12 was estimated using multivariate linear regression.
Regulation (effect) of PCS
14) Confidence 0.12 Published 2006 Journal Health Qual Life Outcomes Section Body Doc Link PMC1562359 Disease Relevance 0.22 Pain Relevance 0.10
Change in the RSDI at the individual level correlated moderately well with changes in the RSS-4, SF-12 PCS, CES-D, and PCRQ.
Regulation (changes) of PCS
15) Confidence 0.11 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1308842 Disease Relevance 0.09 Pain Relevance 0
For ease of interpretation of Table 3 data, estimated predicted values of HAQ, PCS, MCS and EQ-5D are presented at time points of -10 and +10 years, based on adjusted regression analyses.


Regulation (values) of PCS
16) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888182 Disease Relevance 0.19 Pain Relevance 0.07
In one analysis, hypertension alone had an effect on PCS that was comparable to the effect of aging in a 'healthy' population.[21,22] However another longitudinal analysis has shown slightly increased odds of a decline in health status over 2 years in patients with hypertension alone relative to those with no chronic conditions.
Regulation (effect) of PCS associated with aging and hypertension
17) Confidence 0.07 Published 2004 Journal Health Qual Life Outcomes Section Body Doc Link PMC519027 Disease Relevance 0.81 Pain Relevance 0
We completed separate regressions to determine the effect on PCS due to each of the main chronic conditions of interest.
Spec (determine) Regulation (effect) of PCS
18) Confidence 0.07 Published 2004 Journal Health Qual Life Outcomes Section Body Doc Link PMC519027 Disease Relevance 0.78 Pain Relevance 0
When only patients never treated with biologics were considered (Table 2) HAQ scores worsened by 0.016 per year (95% CI 0.013, 0.019), but no significant changes were seen for PCS, MCS, or EQ-5D.
Neg (no) Regulation (changes) of PCS
19) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888182 Disease Relevance 0.29 Pain Relevance 0.07
In clinical trials, a 5 point change in the MCS and PCS are regarded as clinically relevant, whereas statistical significance can be reached with changes in 1-2 points in the scores.


Regulation (change) of PCS
20) Confidence 0.06 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC2954977 Disease Relevance 0.40 Pain Relevance 0

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