INT145946

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Context Info
Confidence 0.59
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 6
Disease Relevance 2.65
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcnk2)
Anatomy Link Frequency
pyramidal neurons 2
pore 1
Kcnk2 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 26 100.00 Very High Very High Very High
antagonist 18 100.00 Very High Very High Very High
antidepressant 274 99.68 Very High Very High Very High
fluoxetine 68 99.08 Very High Very High Very High
Pyramidal cell 16 98.60 Very High Very High Very High
Lamotrigine 2 98.08 Very High Very High Very High
depression 148 95.80 Very High Very High Very High
Raphe 16 84.32 Quite High
Glutamate 6 77.52 Quite High
sSRI 36 69.08 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 52 99.16 Very High Very High Very High
Depression 154 98.24 Very High Very High Very High
Manic Depressive Disorder 6 93.92 High High
Stress 30 89.28 High High
Mental Disorders 6 84.64 Quite High
Neurodegenerative Disease 64 62.28 Quite High
Death 8 23.28 Low Low
Disease 12 5.00 Very Low Very Low Very Low
Shock 12 5.00 Very Low Very Low Very Low
Body Weight 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using the whole-cell patch-clamp technique on TREK-1 transfected COS cells, we first assessed the ability of the full length peptide to inhibit the TREK-1 channel activity.
Negative_regulation (inhibit) of TREK-1
1) Confidence 0.59 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0 Pain Relevance 0
Electrophysiological studies showed that spadin efficiently blocked the TREK-1 activity in COS-7 cells, cultured hippocampal pyramidal neurons, and CA3 hippocampal neurons in brain slices.
Negative_regulation (blocked) of TREK-1 in pyramidal neurons associated with pyramidal cell
2) Confidence 0.59 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2854129 Disease Relevance 0.34 Pain Relevance 0.60
Electrophysiological studies show that spadin efficiently blocks the TREK-1 activity in COS-7 cells, cultured pyramidal neurons, as well as CA3 hippocampal neurons in brain slices of wild-type mice and not in kcnk2?
Negative_regulation (blocks) of TREK-1 in pyramidal neurons associated with pyramidal cell
3) Confidence 0.43 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.06 Pain Relevance 0.24
This is in good agreement with the fact that TREK-1 deficient mice do not show an anxiety-resistant phenotype [1].
Negative_regulation (deficient) of TREK-1 associated with anxiety disorder
4) Confidence 0.43 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.56 Pain Relevance 0.34
Sipatrigine (BW619C89), a neuroprotective agent, has been found to be a potent antagonist of TREK-1.
Negative_regulation (antagonist) of TREK-1 associated with antagonist
5) Confidence 0.43 Published 2008 Journal Med. Hypotheses Section Abstract Doc Link 17703894 Disease Relevance 0.88 Pain Relevance 0.78
Recent studies have demonstrated that the TREK-1 protein, one of the 17 members of the two-pore domain K+ (K2P) potassium channel family, is inhibited by the antidepressant fluoxetine.
Negative_regulation (inhibited) of TREK-1 in pore associated with antidepressant, potassium channel and fluoxetine
6) Confidence 0.43 Published 2008 Journal Med. Hypotheses Section Abstract Doc Link 17703894 Disease Relevance 0.82 Pain Relevance 0.55

General Comments

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