INT145954

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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.81
Pain Relevance 0.47

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plasma membrane (BSG, MME) peptidase activity (MME) mitochondrion (BSG)
small molecule metabolic process (BSG) cell-cell signaling (MME)
BSG (Homo sapiens)
MME (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 3 78.68 Quite High
substance P 3 77.72 Quite High
Enkephalin 3 77.20 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 6 97.60 Very High Very High Very High
Natriuresis 3 79.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, the synthesis and crystal structures of the soluble extracellular domain of human NEP (residues 52-749) complexed with the NEP, competitive and potent dual NEP/DPP-IV inhibitor MCB3937 are described.
extracellular Binding (complexed) of NEP
1) Confidence 0.00 Published 2007 Journal Acta Crystallogr. D Biol. Crystallogr. Section Abstract Doc Link 17704566 Disease Relevance 0.27 Pain Relevance 0.16
Here, the synthesis and crystal structures of the soluble extracellular domain of human NEP (residues 52-749) complexed with the NEP, competitive and potent dual NEP/DPP-IV inhibitor MCB3937 are described.
extracellular Binding (complexed) of NEP
2) Confidence 0.00 Published 2007 Journal Acta Crystallogr. D Biol. Crystallogr. Section Abstract Doc Link 17704566 Disease Relevance 0.27 Pain Relevance 0.16
Here, the synthesis and crystal structures of the soluble extracellular domain of human NEP (residues 52-749) complexed with the NEP, competitive and potent dual NEP/DPP-IV inhibitor MCB3937 are described.
extracellular Binding (complexed) of NEP
3) Confidence 0.00 Published 2007 Journal Acta Crystallogr. D Biol. Crystallogr. Section Abstract Doc Link 17704566 Disease Relevance 0.27 Pain Relevance 0.16

General Comments

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