INT145959

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 2.75
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (DSPP) proteinaceous extracellular matrix (DSPP)
Anatomy Link Frequency
dentin 16
mouth 1
teeth 1
tubule 1
DSPP (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 34 99.98 Very High Very High Very High
anesthesia 9 98.60 Very High Very High Very High
Enkephalin 1 94.40 High High
substance P 2 93.88 High High
bradykinin 2 92.88 High High
rheumatoid arthritis 1 82.12 Quite High
Potency 1 79.36 Quite High
chemokine 2 73.92 Quite High
Neuropeptide 4 72.64 Quite High
cytokine 1 51.40 Quite High
Disease Link Frequency Relevance Heat
Dentin Sensitivity 20 100.00 Very High Very High Very High
Disease 7 97.92 Very High Very High Very High
Cancer 1 95.80 Very High Very High Very High
Dentin Dysplasia 7 94.68 High High
Pain 28 93.04 High High
Diabetes Mellitus 59 92.56 High High
Natriuresis 1 92.00 High High
Smear Layer 136 90.84 High High
Rheumatoid Arthritis 1 82.12 Quite High
Toxicity 1 75.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV.
Negative_regulation (inhibitor) of DPP
1) Confidence 0.57 Published 2007 Journal Acta Crystallogr. D Biol. Crystallogr. Section Title Doc Link 17704566 Disease Relevance 0.24 Pain Relevance 0.19
Shellac F reduced dentin hypersensitivity and did not differ from the two desensitizing agents used as controls.
Negative_regulation (reduced) of dentin in dentin associated with dentin sensitivity
2) Confidence 0.34 Published 2009 Journal J Oral Rehabil Section Abstract Doc Link 19522897 Disease Relevance 0.51 Pain Relevance 0.09
Previous in vitro permeability and scanning electron microscopic studies have demonstrated the effectiveness of a new natural based-resin varnish (Shellac F) in dentin permeability reduction and effective tubule occlusion.
Negative_regulation (reduction) of dentin in tubule
3) Confidence 0.30 Published 2009 Journal J Oral Rehabil Section Abstract Doc Link 19522897 Disease Relevance 0.16 Pain Relevance 0
The aim of this randomized double-blind, controlled, split mouth 8-week clinical study was to evaluate the efficiency of Shellac F in reducing dentin hypersensitivity.
Negative_regulation (reducing) of dentin in mouth associated with dentin sensitivity
4) Confidence 0.30 Published 2009 Journal J Oral Rehabil Section Abstract Doc Link 19522897 Disease Relevance 0.17 Pain Relevance 0
Clinical efficiency of a natural resin fluoride varnish (Shellac F) in reducing dentin hypersensitivity.
Negative_regulation (reducing) of dentin in dentin associated with dentin sensitivity
5) Confidence 0.30 Published 2009 Journal J Oral Rehabil Section Title Doc Link 19522897 Disease Relevance 0.18 Pain Relevance 0
Although there seems to be no need to identify more than 2 distinct types of this relatively rare inherited defect of human dentin, the possible existence of additional forms of the disease cannot be ruled out.
Negative_regulation (defect) of dentin in dentin associated with disease
6) Confidence 0.26 Published 2009 Journal Quintessence Int Section Abstract Doc Link 19417880 Disease Relevance 0.76 Pain Relevance 0.08
Currently, all data obtained using ‘nonselective’ and ‘selective’ DPP inhibitors need to be interpreted with caution.
Negative_regulation (inhibitors) of DPP
7) Confidence 0.13 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597770 Disease Relevance 0.43 Pain Relevance 0.33
Chemomechanical caries removal involves the selective removal of soft carious dentin without the painful removal of sound dentin.
Negative_regulation (removal) of dentin in dentin associated with pain
8) Confidence 0.03 Published 2010 Journal International Journal of Dentistry Section Body Doc Link PMC2862321 Disease Relevance 0 Pain Relevance 0.17
Chemomechanical caries removal involves the selective removal of soft carious dentin without the painful removal of sound dentin.
Negative_regulation (removal) of dentin in dentin associated with pain
9) Confidence 0.03 Published 2010 Journal International Journal of Dentistry Section Body Doc Link PMC2862321 Disease Relevance 0 Pain Relevance 0.17
In addition, unwanted removal of sound dentin is avoided and the need for local anesthesia is less.
Negative_regulation (removal) of dentin in dentin associated with anesthesia
10) Confidence 0.03 Published 2010 Journal International Journal of Dentistry Section Body Doc Link PMC2862321 Disease Relevance 0 Pain Relevance 0.18
Researchers have stated that in the determination of the complete removal of the carious dentin, color (visual criteria) and hardness (tactile criteria) have been used as criteria for the clinical assessment.3 Estimation of hardness of the remaining dentin by tactile procedures, however, may not be a reliable guide for the clinical removal of caries.3 Discoloration is considered reliable only in chronic caries where it is usually marked, and that the extent of bacterial invasion follows closely the discoloration front.
Negative_regulation (removal) of dentin in dentin
11) Confidence 0.01 Published 2008 Journal European Journal of Dentistry Section Body Doc Link PMC2635900 Disease Relevance 0 Pain Relevance 0
The usefulness of DIAGNOdent device for the assessment of carious dentin removal has previously been reported by Lussi et al.16 The distribution of DIAGNOdent values in primary teeth exhibits a difference in an unimportant degree with respect to that of permanent teeth.17 The best performance of DIAGNOdent is said to be in dentinal caries which is emerged by opening the fissure18 and to predict the extension of caries lesions, mainly at dentinal caries threshold in primary teeth. 19
Negative_regulation (removal) of dentin in teeth
12) Confidence 0.01 Published 2008 Journal European Journal of Dentistry Section Body Doc Link PMC2635900 Disease Relevance 0.19 Pain Relevance 0
In acute caries, the zones of discoloration are less evident, and bacterial invasion is usually diffuse and extends beyond the discoloration front.3 Thus, discoloration is not a reliable guide for the removal of infected dentin.
Negative_regulation (removal) of dentin in dentin
13) Confidence 0.01 Published 2008 Journal European Journal of Dentistry Section Body Doc Link PMC2635900 Disease Relevance 0 Pain Relevance 0
The aim of this study was to evaluate the performance of a visual-tactile examination and a laser fluorescence device for detecting residual dentinal caries after carious dentin removal with bur excavation, hand excavation and chemomechanical excavation (Carisolv™].


Negative_regulation (removal) of dentin in dentin
14) Confidence 0.01 Published 2008 Journal European Journal of Dentistry Section Abstract Doc Link PMC2635900 Disease Relevance 0 Pain Relevance 0
Excessive removal of dentin has been reported when these dyes were used to remove caries.5
Negative_regulation (removal) of dentin in dentin
15) Confidence 0.01 Published 2008 Journal European Journal of Dentistry Section Body Doc Link PMC2635900 Disease Relevance 0 Pain Relevance 0
It has been shown that the DIAGNOdent readings were useful to facilitate accurate removal of the caries-infected dentin.20 Further, Yazici et al9 stated that DIAGNOdent agreed better than the caries detector dye with the histological evaluation in assessing teeth with residual caries.
Negative_regulation (removal) of dentin in dentin
16) Confidence 0.01 Published 2008 Journal European Journal of Dentistry Section Body Doc Link PMC2635900 Disease Relevance 0 Pain Relevance 0
The aim of this in vitro study was to compare the performance of a visual-tactile examination and a laser fluorescence device (DIAGNOdent) for detection of residual dentinal caries after carious dentin removal with the bur excavation, hand excavation and Carisolv system.
Negative_regulation (removal) of dentin in dentin
17) Confidence 0.01 Published 2008 Journal European Journal of Dentistry Section Body Doc Link PMC2635900 Disease Relevance 0.09 Pain Relevance 0
Yamada et al25 stated that the efficiency of complete carious dentin removal by the Carisolv system in no longer difficult when a proper clinical guide (e.g.
Negative_regulation (removal) of dentin in dentin
18) Confidence 0.01 Published 2008 Journal European Journal of Dentistry Section Body Doc Link PMC2635900 Disease Relevance 0 Pain Relevance 0
After removal of the caries-infected dentin DIAGNOdent readings were retaken in all groups.
Negative_regulation (removal) of dentin in dentin
19) Confidence 0.01 Published 2008 Journal European Journal of Dentistry Section Body Doc Link PMC2635900 Disease Relevance 0 Pain Relevance 0
After repeating Caries Detector staining, removal of carious dentin was stopped when the cavity floor dentin stained light pink in groups.
Negative_regulation (removal) of dentin in dentin
20) Confidence 0.01 Published 2008 Journal European Journal of Dentistry Section Body Doc Link PMC2635900 Disease Relevance 0 Pain Relevance 0

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