INT14597

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Context Info
Confidence 0.37
First Reported 1990
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.52
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Tpsab1) extracellular region (Tpsab1)
Anatomy Link Frequency
mast cell 2
Tpsab1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Codeine 5 99.68 Very High Very High Very High
Serotonin 6 99.36 Very High Very High Very High
agonist 4 97.44 Very High Very High Very High
corticosteroid 5 96.56 Very High Very High Very High
Inflammation 45 95.84 Very High Very High Very High
lidocaine 1 91.08 High High
antagonist 6 89.52 High High
cytokine 13 88.24 High High
Hyperalgesia 1 87.88 High High
substance P 35 83.24 Quite High
Disease Link Frequency Relevance Heat
Anaphylaxis 7 98.36 Very High Very High Very High
INFLAMMATION 40 95.84 Very High Very High Very High
Neurogenic Inflammation 9 94.72 High High
Adverse Drug Reaction 2 94.68 High High
Asthma 10 92.56 High High
Hyperalgesia 1 87.88 High High
Hypersensitivity 7 78.96 Quite High
Drug Hypersensitivity 1 48.96 Quite Low
Disease 6 9.16 Low Low
Bacterial Infection 1 7.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our series, positive and negative predictive values of tryptase at T(0) for the diagnosis of anaphylaxis were 100% and 60%, respectively.
Negative_regulation (values) of tryptase
1) Confidence 0.37 Published 2008 Journal Acta Anaesthesiol Scand Section Body Doc Link 18005384 Disease Relevance 0.06 Pain Relevance 0
Levels of both tryptase and PGD2 were increased after the first hour of Ag or codeine challenge, and tryptase decreased progressively thereafter at all sites.
Negative_regulation (decreased) of tryptase associated with codeine
2) Confidence 0.14 Published 1990 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 1698845 Disease Relevance 0 Pain Relevance 0.44
A prospective evaluation of tryptase, histamine and serotonin for diagnosing anaphylaxis to anaesthetics was performed over 2 years.
Negative_regulation (evaluation) of tryptase associated with anaphylaxis and serotonin
3) Confidence 0.12 Published 1998 Journal Clin. Exp. Allergy Section Abstract Doc Link 9761037 Disease Relevance 0.35 Pain Relevance 0.13
In addition, a tryptase inhibitor suppressed calcium mobilization in response to degranulated mast cells.
Negative_regulation (inhibitor) of tryptase in mast cells
4) Confidence 0.07 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.26 Pain Relevance 0.48
Inhibition of mast cell products by existing drugs such as heparin or the development of specific inhibitors of mast cell tryptase may also be effective agents, as are selective phosphodiesterase inhibitors, which appear to have anti-inflammatory properties.
Negative_regulation (inhibitors) of tryptase in mast cell associated with inflammation
5) Confidence 0.05 Published 1997 Journal Curr Opin Pulm Med Section Abstract Doc Link 9139770 Disease Relevance 0.85 Pain Relevance 0.54

General Comments

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