INT145971

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Context Info
Confidence 0.81
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 10.30
Pain Relevance 18.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
ganglion cell layer 4
sciatic nerve 2
sensory neuron 1
myofibril 1
cardiac myocytes 1
Nav1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 236 100.00 Very High Very High Very High
Nav1.2 123 100.00 Very High Very High Very High
nav1.8 114 100.00 Very High Very High Very High
nav1.3 65 100.00 Very High Very High Very High
Nav1.1 49 100.00 Very High Very High Very High
Nav1.6 30 100.00 Very High Very High Very High
Nav1.9 16 100.00 Very High Very High Very High
Nav1.7 7 99.88 Very High Very High Very High
tetrodotoxin 73 99.80 Very High Very High Very High
Central nervous system 6 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 213 99.68 Very High Very High Very High
Injury 231 99.32 Very High Very High Very High
Nerve Compression Syndromes 124 99.28 Very High Very High Very High
Multiple Trauma 4 99.08 Very High Very High Very High
Dyspepsia 41 98.76 Very High Very High Very High
Nociception 48 98.40 Very High Very High Very High
Neuropathic Pain 83 98.32 Very High Very High Very High
Poisoning 1 97.04 Very High Very High Very High
Non-diabetic Peripheral Neuropathy 12 94.72 High High
Pain 60 89.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results confirmed that Nav1.1, Nav1.2, Nav1.3, and Nav1.6 are localized in the ganglion cell layer (GCL).
Localization (localized) of Nav1 in ganglion cell layer associated with ganglion cysts, nav1.3, nav1.1, nav1.2 and nav1.6
1) Confidence 0.81 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17709186 Disease Relevance 0.17 Pain Relevance 2.05
Our results confirmed that Nav1.1, Nav1.2, Nav1.3, and Nav1.6 are localized in the ganglion cell layer (GCL).
Localization (localized) of Nav1 in ganglion cell layer associated with ganglion cysts, nav1.3, nav1.1, nav1.2 and nav1.6
2) Confidence 0.81 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17709186 Disease Relevance 0.17 Pain Relevance 2.06
Our results confirmed that Nav1.1, Nav1.2, Nav1.3, and Nav1.6 are localized in the ganglion cell layer (GCL).
Localization (localized) of Nav1 in ganglion cell layer associated with ganglion cysts, nav1.3, nav1.1, nav1.2 and nav1.6
3) Confidence 0.81 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17709186 Disease Relevance 0.17 Pain Relevance 2.04
Our results confirmed that Nav1.1, Nav1.2, Nav1.3, and Nav1.6 are localized in the ganglion cell layer (GCL).
Localization (localized) of Nav1 in ganglion cell layer associated with ganglion cysts, nav1.3, nav1.1, nav1.2 and nav1.6
4) Confidence 0.81 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17709186 Disease Relevance 0.17 Pain Relevance 2.05
Nav1.4 (which is normally expressed within skeletal muscle), Nav1.5 (cardiac muscle), Nav1.7, Nav1.8, and Nav1.9 (normally expressed in peripheral ganglia and not in brain) were not studied.


Localization (cardiac muscle) of Nav1 in ganglia associated with nav1.8, nav1.7 and nav1.9
5) Confidence 0.75 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 0.21 Pain Relevance 0.84
Nav1.8, formerly called the sensory neuron-specific or the peripheral nerve sodium channel type 3, is expressed exclusively in sensory neurons and is not found in the central nervous system (CNS) [5].
Neg (not) Localization (found) of Nav1 in sensory neuron associated with sodium channel, central nervous system and nav1.8
6) Confidence 0.75 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894792 Disease Relevance 1.46 Pain Relevance 2.40
-actin antibody (green fluorescence) to examine the localization of Nav channels (Fig. 1C).
Spec (examine) Localization (localization) of Nav
7) Confidence 0.71 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2752992 Disease Relevance 0 Pain Relevance 0.25
Several mechanisms may underly the peripheral translocation of NaV1.8 protein observed in multiple injury models.
Localization (translocation) of NaV1 associated with multiple trauma
8) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 1.87 Pain Relevance 0.83
Also, the mechanism by which peripheral translocation of NaV1.8 occurs in the CCI model is unclear [11].
Localization (translocation) of NaV1 associated with eae
9) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 1.24 Pain Relevance 0.88
This peripheral translocation of Nav1.8 together with increased TTX-resistance suggests involvement of peripherally accumulated NaV1.8 in sciatic nerve hyperexcitability after SNE injury.
Localization (translocation) of Nav1 in sciatic nerve associated with injury, nerve compression syndromes, sciatic nerve, nav1.8 and hyperexcitability
10) Confidence 0.58 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 1.87 Pain Relevance 1.00
At the 5-day timepoint, when new cell-cell contacts are forming and ankyrin-G is beginning to co-localize to cell contact sites, immunostaining for Nav1.5 demonstrates a more diffuse localization (Figures 9(a)–9(d)).
Localization (localization) of Nav1
11) Confidence 0.57 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2868981 Disease Relevance 0.11 Pain Relevance 0.06
While previous studies have examined the relationship of desmosomal and gap junction assembly in redifferentiating cardiac myocytes as noted above, the localization of Nav1.5 to the ID has not been well described.
Localization (localization) of Nav1 in cardiac myocytes
12) Confidence 0.54 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2868981 Disease Relevance 0.28 Pain Relevance 0.41
Therefore, to determine the structural requirements for the recruitment of the VGSC to newly formed IDs, the pattern of localization of ankyrin-G, Nav1.5, and the desmosomal protein PKP2 was examined at 5 and 13 days post plating.
Localization (localization) of Nav1 associated with sodium channel
13) Confidence 0.54 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2868981 Disease Relevance 0.25 Pain Relevance 0.13
That ankyrin-G co-localized with Nav1.5 to these sites suggests that the immunostaining is specific and may represent a developmental intermediate as the membrane domains reorganize in the redifferentiation phase of remodeling.
Localization (localized) of Nav1
14) Confidence 0.54 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2868981 Disease Relevance 0 Pain Relevance 0
Whether or not this truly represents localization of Nav1.5 to membrane structures associated with the myofibril remains to be determined.
Localization (localization) of Nav1 in myofibril
15) Confidence 0.54 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2868981 Disease Relevance 0 Pain Relevance 0.03
Later relocalization of Nav1.5 to the ID was demonstrated by immunostaining at 13 days post plating (Figures 9(e)–9(g)).


Localization (relocalization) of Nav1
16) Confidence 0.54 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2868981 Disease Relevance 0 Pain Relevance 0
To address the mechanisms of NaV1.8 translocation and its potential relationship to hyperexcitability, we studied sciatic nerve excitability and NaV1.8 expression in a rat model of painful neuropathy induced by sciatic nerve entrapment (SNE).
Localization (translocation) of NaV1 in sciatic nerve associated with pain, nerve compression syndromes, sciatic nerve and hyperexcitability
17) Confidence 0.47 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 1.22 Pain Relevance 0.90
We demonstrated that CANs co-localize with Nav1.9, a sodium channel that is present on nociceptive DRG neurons as well as enteric neurons [25,26].
Localization (localize) of Nav1 in neurons associated with nociception, dorsal root ganglion, sodium channel and nav1.9
18) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2758842 Disease Relevance 1.09 Pain Relevance 0.94
Strikingly, Kv2.1-Nav1.2 E1111A was correctly localized at the AIS in 52.7 ± 13.9% (n = 178) of the cells displaying surface staining (Fig. 1, D–F, and Fig. 2 E).
Localization (localized) of Nav1 associated with nav1.2
19) Confidence 0.32 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2600743 Disease Relevance 0 Pain Relevance 1.01
The sketch gives an overview of locations of known NaV1.4 mutations
Localization (locations) of NaV1
20) Confidence 0.31 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883924 Disease Relevance 0 Pain Relevance 0.20

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