INT14598

Context Info Confidence 0.73 First Reported 1990 Last Reported 2010 Negated 4 Speculated 3 Reported most in Abstract Documents 40 Total Number 43 Disease Relevance 14.55 Pain Relevance 5.40

peptidase activity (Tpsab1) extracellular region (Tpsab1)

Anatomy Link Frequency mast cell 15 epithelial cells 2 fibroblasts 2 trachea 2 colons 1 Tpsab1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Codeine 5 98.48 anesthesia 16 98.40 chemokine 1 97.96 cytokine 31 97.36 Inflammation 117 96.96 fibrosis 2 95.20 Pain 26 94.84 aspirin 12 93.40 endometriosis 5 93.20 abdominal pain 8 93.00

Disease Link Frequency Relevance Heat Adhesions 3 100.00 Adverse Drug Reaction 2 99.84 Injury 67 99.74 Darier's Disease 2 99.44 Anaphylaxis 26 99.16 Urticaria Pigmentosa 4 99.04 Wound Healing 25 98.60 Hyperplasia 4 97.80 Rupture 10 97.20 Hypersensitivity 18 96.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Tryptase is predominantly found in mast cells, where it resides in secretory granules, and is released with other mediators during mast cell degranulation.

Gene_expression (found) of Tryptase in mast cell

1) Confidence 0.73 Published 1991 Journal Agents Actions Section Abstract Doc Link 1897443 Disease Relevance 0.22 Pain Relevance 0

RESULTS: The patients' spot urine sample tryptase levels were indistinguishable from those of controls, which included the normal women volunteers.

Gene_expression (levels) of tryptase in urine

2) Confidence 0.64 Published 1995 Journal Br J Urol Section Body Doc Link 7648070 Disease Relevance 0.14 Pain Relevance 0

No correlation was found between the IgE levels and tryptase in either group, supporting the hypothesis that tryptase release was not mediated by an allergic reaction.

Gene_expression (levels) of tryptase associated with hypersensitivity

3) Confidence 0.61 Published 1997 Journal Allergy Section Abstract Doc Link 9298181 Disease Relevance 0.33 Pain Relevance 0.26

No correlation was found between the IgE levels and tryptase in either group, supporting the hypothesis that tryptase release was not mediated by an allergic reaction.

Neg (No) Gene_expression (found) of tryptase associated with hypersensitivity

4) Confidence 0.61 Published 1997 Journal Allergy Section Abstract Doc Link 9298181 Disease Relevance 0.33 Pain Relevance 0.26

In an anaphylactic reaction of grade II, which happened after the administering of vecuronium, tryptase was not detected.

Neg (not) Gene_expression (detected) of tryptase associated with anaphylaxis

5) Confidence 0.59 Published 1996 Journal Allerg Immunol (Paris) Section Abstract Doc Link 9011165 Disease Relevance 0.17 Pain Relevance 0

METHOD: Plasma levels of tryptase, a specific marker for mast cell degranulation, were measured by immuno-assay at baseline and 60 min after heroin administration.

Gene_expression (levels) of tryptase in mast cell

6) Confidence 0.59 Published 2006 Journal Drug Alcohol Depend Section Body Doc Link 16765536 Disease Relevance 0 Pain Relevance 0

The common signs in both cases were skin changes of urticaria pigmentosa, presence of Darier's symptom, very high blood levels of tryptase and prostaglandin D2 and rise in urinary LTE4 concentration.

Gene_expression (levels) of tryptase in blood associated with darier's disease and urticaria pigmentosa

7) Confidence 0.59 Published 2001 Journal Pol. Arch. Med. Wewn. Section Abstract Doc Link 11761803 Disease Relevance 0.73 Pain Relevance 0.09

The mast cell tryptase was also significantly elevated at 76 microg/L, (Normal 2-14 microg/L).

Gene_expression (The) of tryptase in mast cell

8) Confidence 0.57 Published 2009 Journal Am J Forensic Med Pathol Section Abstract Doc Link 19465816 Disease Relevance 0.96 Pain Relevance 0.48

Although preliminary due to the limited numbers of patients, they also suggest that increased levels of neurotrophin-3, nerve growth factor, glial cell line-derived neurotrophic factor and tryptase in the urine could serve as a basis for adjunct diagnosis, monitoring and treatment of interstitial cystitis.

Gene_expression (levels) of tryptase in glial cell

9) Confidence 0.48 Published 1999 Journal J. Urol. Section Body Doc Link 9915421 Disease Relevance 0 Pain Relevance 0

CONCLUSION: Serum levels of tryptase are not elevated in patients with acute coronary syndromes.

Gene_expression (levels) of tryptase

10) Confidence 0.41 Published 2001 Journal Int. J. Cardiol. Section Body Doc Link 11259815 Disease Relevance 0.06 Pain Relevance 0

Levels of tryptase did not differ between patients with acute myocardial infarction (7.9+/-4.6 microg/l), unstable angina pectoris (6.0+/-2.1 microg/l) or controls (6.9+/-4.1 microg/l), nor could a relation with levels of C-reactive protein be demonstrated.

Gene_expression (Levels) of tryptase

11) Confidence 0.41 Published 2001 Journal Int. J. Cardiol. Section Body Doc Link 11259815 Disease Relevance 0.07 Pain Relevance 0

METHODS: Serum levels of tryptase were determined in the following three groups of patients: 13 patients with acute myocardial infarction, 10 patients with unstable angina pectoris, and 14 patients without ischaemic cardiovascular disease who were used as controls.

Gene_expression (levels) of tryptase

12) Confidence 0.41 Published 2001 Journal Int. J. Cardiol. Section Body Doc Link 11259815 Disease Relevance 0.09 Pain Relevance 0

Mast cell activity can be determined by measuring serum levels of tryptase, as has been demonstrated in patients with anaphylaxis and mastcytosis.

Gene_expression (levels) of tryptase in Mast cell associated with anaphylaxis

13) Confidence 0.41 Published 2001 Journal Int. J. Cardiol. Section Abstract Doc Link 11259815 Disease Relevance 1.07 Pain Relevance 0.27

HYPOTHESIS: Acute coronary events (acute myocardial infarction and unstable angina pectoris) are associated with increased mast cell activity, reflected by elevated serum tryptase levels.

Gene_expression (levels) of tryptase in mast cell

14) Confidence 0.36 Published 2001 Journal Int. J. Cardiol. Section Body Doc Link 11259815 Disease Relevance 0.09 Pain Relevance 0

Synchronous appearance of fibronectin, integrin alpha 5 beta 1, vinculin and actin in epithelial cells and fibroblasts during rat tracheal wound healing.

Gene_expression (appearance) of alpha 5 beta 1 in epithelial cells associated with wound healing

15) Confidence 0.31 Published 1994 Journal Virchows Arch. Section Title Doc Link 7529621 Disease Relevance 0.51 Pain Relevance 0.09

The appearances of fibronectin, alpha 5 beta 1, vinculin and actin in regenerating epithelial cells and fibroblasts during tracheal wound healing are well coordinated.

Gene_expression (appearances) of alpha 5 beta 1 in epithelial cells associated with wound healing

16) Confidence 0.31 Published 1994 Journal Virchows Arch. Section Abstract Doc Link 7529621 Disease Relevance 0.51 Pain Relevance 0.06

Immunoelectron microscopy 2 days after injury showed that alpha 5 beta 1 and vinculin were localized on the basal and lateral surfaces of regenerating epithelial cells and fibroblast surfaces, and fibronectin was localized just under the regenerating epithelial cells, around collagen fibrils and sporadically around fibroblasts.

Gene_expression (localized) of alpha 5 beta 1 in lateral surfaces associated with injury

17) Confidence 0.31 Published 1994 Journal Virchows Arch. Section Abstract Doc Link 7529621 Disease Relevance 0.56 Pain Relevance 0.08

Brownish granules in the cytoplasm were recognized as positive staining for tryptase.

Gene_expression (staining) of tryptase

18) Confidence 0.31 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2564972 Disease Relevance 0 Pain Relevance 0.03

We calculated the tryptase positive mast cells in 5 representative areas at 400× magnification by Image-Pro Plus 5.0 (USA) Statistics

Gene_expression (mast cells) of tryptase in mast cells

19) Confidence 0.31 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2564972 Disease Relevance 0.05 Pain Relevance 0.05

BACKGROUND: Mast cell tryptase is used clinically in the evaluation of anaphylaxis during anesthesia, because symptoms and signs of anaphylaxis are often masked by the effect of anesthesia.

Gene_expression (used) of tryptase in Mast cell associated with anesthesia and anaphylaxis

20) Confidence 0.30 Published 2010 Journal Anesthesiology Section Abstract Doc Link 20395827 Disease Relevance 0.20 Pain Relevance 0.43

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