INT14599

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Context Info
Confidence 0.79
First Reported 1990
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 36
Total Number 38
Disease Relevance 14.58
Pain Relevance 7.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Tpsab1) extracellular region (Tpsab1)
Anatomy Link Frequency
mast cells 19
visceral 1
plasma 1
gut 1
blood 1
Tpsab1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 20 99.80 Very High Very High Very High
Codeine 32 99.14 Very High Very High Very High
corticosteroid 22 99.04 Very High Very High Very High
spastic colon 74 98.92 Very High Very High Very High
Morphine 5 97.24 Very High Very High Very High
Neuropeptide 29 97.16 Very High Very High Very High
Opioid 6 96.68 Very High Very High Very High
c fibre 4 96.20 Very High Very High Very High
anesthesia 8 95.96 Very High Very High Very High
cINOD 8 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anaphylaxis 34 100.00 Very High Very High Very High
Hypersensitivity 18 99.96 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

71 99.26 Very High Very High Very High
Diarrhoea 8 98.94 Very High Very High Very High
Overdose 2 97.48 Very High Very High Very High
Coagulation Disorder 6 96.96 Very High Very High Very High
Mastocytosis 9 96.88 Very High Very High Very High
Stress 111 96.72 Very High Very High Very High
Nociception 2 96.28 Very High Very High Very High
Systemic Mastocytosis 9 95.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, plasma was assayed for tryptase, a marker of mast cell release.
Localization (release) of tryptase in plasma
1) Confidence 0.79 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9052314 Disease Relevance 0.16 Pain Relevance 0.09
Many agents used in anaesthesia can trigger mast cell degranulation with release of histamine, prostaglandin, tryptase and heparin.
Localization (release) of tryptase in mast cell
2) Confidence 0.79 Published 2009 Journal Anaesthesist Section Abstract Doc Link 19795098 Disease Relevance 0.27 Pain Relevance 0.14
During the IgE-mediated anaphylactic reaction mast cells release proteases such as tryptase, histamine and vasoactive mediators.
Localization (release) of tryptase in mast cells associated with anaphylaxis
3) Confidence 0.79 Published 2006 Journal Lijec Vjesn Section Abstract Doc Link 17128671 Disease Relevance 0.43 Pain Relevance 0.16
The number of mast cells in rectal biopsies and spontaneous release of tryptase were lower in patients with IBS than in healthy volunteers.
Localization (release) of tryptase in mast cells
4) Confidence 0.79 Published 2010 Journal Gut Section Body Doc Link 20650926 Disease Relevance 0 Pain Relevance 0
In addition, mast cells were quantified and spontaneous release of tryptase and histamine was determined in rectal biopsies and compared with biopsies from 22 age- and gender-matched healthy volunteers.
Localization (release) of tryptase in mast cells
5) Confidence 0.79 Published 2010 Journal Gut Section Body Doc Link 20650926 Disease Relevance 0 Pain Relevance 0
Tryptase is predominantly found in mast cells, where it resides in secretory granules, and is released with other mediators during mast cell degranulation.
Localization (released) of Tryptase in mast cells
6) Confidence 0.76 Published 1991 Journal Agents Actions Section Abstract Doc Link 1897443 Disease Relevance 0.24 Pain Relevance 0
No correlation was found between the IgE levels and tryptase in either group, supporting the hypothesis that tryptase release was not mediated by an allergic reaction.
Localization (release) of tryptase associated with hypersensitivity
7) Confidence 0.73 Published 1997 Journal Allergy Section Abstract Doc Link 9298181 Disease Relevance 0.32 Pain Relevance 0.26
After heroin inhalation, no tryptase release was observed.
Localization (release) of tryptase
8) Confidence 0.69 Published 2006 Journal Drug Alcohol Depend Section Body Doc Link 16765536 Disease Relevance 0 Pain Relevance 0
Histamine and tryptase release were not altered by ketotifen.
Localization (release) of tryptase
9) Confidence 0.69 Published 2010 Journal Gut Section Body Doc Link 20650926 Disease Relevance 0 Pain Relevance 0
Histamine and tryptase, released during anaphylactoid reactions in anaesthesia, can be measured out by radioimmunoassay, provided that their own pharmacokinetic is respected.
Localization (released) of tryptase
10) Confidence 0.69 Published 1996 Journal Allerg Immunol (Paris) Section Abstract Doc Link 9011165 Disease Relevance 0.07 Pain Relevance 0
RESULTS: Although a significant accumulation of histamine was found in inflamed IBD-tissue, the results indicate, however, that this premedication does not enhance the release of histamine or tryptase from gut mucosal samples, neither in the histologically normal mucosa of control persons nor in tissue unaffected or affected by inflammatory bowel disease.
Localization (release) of tryptase in gut
11) Confidence 0.69 Published 1995 Journal Endoscopy Section Body Doc Link 8549437 Disease Relevance 0 Pain Relevance 0
PATIENTS AND METHODS: The secretion of the mast cell mediators histamine and tryptase was followed from biopsies of patients with and without premedication for 30 minutes in an air-bubbled incubation medium (mucosa oxygenation).
Localization (secretion) of tryptase in mast cell
12) Confidence 0.69 Published 1995 Journal Endoscopy Section Body Doc Link 8549437 Disease Relevance 0 Pain Relevance 0
The release of mast cell mediators like histamine and tryptase may lead to allergic symptoms.
Localization (release) of tryptase in mast cell associated with hypersensitivity
13) Confidence 0.69 Published 2006 Journal Drug Alcohol Depend Section Abstract Doc Link 16765536 Disease Relevance 0.10 Pain Relevance 0.27
This measurement is more comprehensive as it measures the release of serum tryptase from both the tissue mastocytes (MCTC) as well as the mucosal mastocytes (MCM).
Localization (release) of tryptase in mastocytes
14) Confidence 0.64 Published 1997 Journal Allerg Immunol (Paris) Section Abstract Doc Link 9453735 Disease Relevance 0.48 Pain Relevance 0.09
Mucosal content of tryptase was increased in IBS and mast cells spontaneously released more tryptase (3.22 +/- 3.48 pmol/min/mg vs. 0.87 +/- 0.65 pmol/min/mg, respectively; P = 0.015) and histamine (339.7 +/- 59.0 ng/g vs. 169.3 +/- 130.6 ng/g, respectively; P = 0.015).
Localization (released) of tryptase in mast cells
15) Confidence 0.50 Published 2004 Journal Gastroenterology Section Body Doc Link 14988823 Disease Relevance 0.07 Pain Relevance 0
Mast cell tryptase and histamine release were analyzed immunoenzymatically.
Spec (analyzed) Localization (release) of tryptase in Mast cell
16) Confidence 0.50 Published 2004 Journal Gastroenterology Section Body Doc Link 14988823 Disease Relevance 0.09 Pain Relevance 0
Epithelial response in both groups was associated with similar increases in luminal tryptase and alpha-defensins release.
Localization (release) of tryptase
17) Confidence 0.39 Published 2008 Journal Gastroenterology Section Body Doc Link 18455999 Disease Relevance 0 Pain Relevance 0
The time of appearance of the serum tryptase peak differed considerably among patients with similar clinical reactions (from 30 min to 6 h) and was independent of the latent period, severity of symptoms, or the amount of tryptase released.
Localization (released) of tryptase
18) Confidence 0.37 Published 1997 Journal Allergy Section Abstract Doc Link 9404562 Disease Relevance 0.93 Pain Relevance 0.19
On the other hand, mast cell mediators released, e.g. histamine, tryptase and nerve growth factor, can in turn excite and stimulate surrounding neuropeptide-containing C-fibers possibly resulting in feedforward loop and potentiation of neurogenic inflammation.
Localization (released) of tryptase in nerve associated with c fibre, inflammation, nerve growth factor, neuropeptide and neurogenic inflammation
19) Confidence 0.36 Published 2010 Journal G Ital Dermatol Venereol Section Abstract Doc Link 20467393 Disease Relevance 0.64 Pain Relevance 0.49
Tryptase released upon mucosal mast cell degranulation can activate PAR2 (26).
Localization (released) of Tryptase in mast cell
20) Confidence 0.36 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 0.89 Pain Relevance 0.65

General Comments

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