INT145996

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gars) ligase activity (Gars) cytoplasm (Gars)
Anatomy Link Frequency
pore 1
Gars (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 5 99.44 Very High Very High Very High
Hippocampus 11 58.60 Quite High
antagonist 4 57.84 Quite High
Spinal cord 11 50.00 Quite Low
Pain 7 25.00 Low Low
spinal dorsal horn 17 5.00 Very Low Very Low Very Low
Neuronal excitability 4 5.00 Very Low Very Low Very Low
GABAergic 3 5.00 Very Low Very Low Very Low
IPN 2 5.00 Very Low Very Low Very Low
Pyramidal cell 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Premenstrual Syndrome 6 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Nociception 4 5.00 Very Low Very Low Very Low
Epilepsy 2 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Inflammatory Pain 2 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low
Affective Disorder 1 5.00 Very Low Very Low Very Low
Convulsion 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We were interested to know whether E2 and PGN share a common binding site on GlyRs.
GlyRs Binding (binding) of
1) Confidence 0.18 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0 Pain Relevance 0.06
These results define the orientation of PTXININ and PTN binding in the alpha1 GlyR pore and allow us to conclude that the relatively reduced sensitivity of PTN at GABA(A)Rs and alpha2 and alpha3 GlyRs is due predominantly to its larger size and reduced ability to form hydrophobic interactions with 2' alanines.
GlyRs Binding (interactions) of in pore associated with gaba
2) Confidence 0.03 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17714449 Disease Relevance 0 Pain Relevance 0.17

General Comments

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