INT145996

Context Info Confidence 0.18 First Reported 2007 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0 Pain Relevance 0.23

mitochondrion (Gars) ligase activity (Gars) cytoplasm (Gars)

Anatomy Link Frequency pore 1 Gars (Rattus norvegicus)

Pain Link Frequency Relevance Heat gABA 5 99.44 Hippocampus 11 58.60 antagonist 4 57.84 Spinal cord 11 50.00 Pain 7 25.00 spinal dorsal horn 17 5.00 Neuronal excitability 4 5.00 GABAergic 3 5.00 IPN 2 5.00 Pyramidal cell 2 5.00

Disease Link Frequency Relevance Heat Premenstrual Syndrome 6 5.00 Pain 5 5.00 Nociception 4 5.00 Epilepsy 2 5.00 Anxiety Disorder 2 5.00 Disease 2 5.00 Inflammatory Pain 2 5.00 Decapitation 1 5.00 Affective Disorder 1 5.00 Convulsion 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We were interested to know whether E2 and PGN share a common binding site on GlyRs.

GlyRs Binding (binding) of

1) Confidence 0.18 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0 Pain Relevance 0.06

These results define the orientation of PTXININ and PTN binding in the alpha1 GlyR pore and allow us to conclude that the relatively reduced sensitivity of PTN at GABA(A)Rs and alpha2 and alpha3 GlyRs is due predominantly to its larger size and reduced ability to form hydrophobic interactions with 2' alanines.

GlyRs Binding (interactions) of in pore associated with gaba

2) Confidence 0.03 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17714449 Disease Relevance 0 Pain Relevance 0.17

General Comments

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