INT145998

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.31
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gars) ligase activity (Gars) cytoplasm (Gars)
Anatomy Link Frequency
brain 1
pore 1
Gars (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 10 100.00 Very High Very High Very High
agonist 2 98.88 Very High Very High Very High
Cannabinoid 10 98.70 Very High Very High Very High
Spinal cord 25 95.64 Very High Very High Very High
Neuronal excitability 8 88.32 High High
Potency 1 85.68 High High
antagonist 8 83.24 Quite High
Hippocampus 22 82.72 Quite High
Analgesic 2 66.76 Quite High
GABAergic 6 43.92 Quite Low
Disease Link Frequency Relevance Heat
Disease 5 80.16 Quite High
Premenstrual Syndrome 12 77.52 Quite High
Anxiety Disorder 4 74.32 Quite High
Convulsion 2 49.84 Quite Low
Pain 14 36.72 Quite Low
Injury 16 34.48 Quite Low
Nociception 8 13.68 Low Low
Affective Disorder 2 7.20 Low Low
Epilepsy 4 5.00 Very Low Very Low Very Low
Inflammatory Pain 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, we propose that E2 directly binds to and allosterically inhibits GlyRs.


Negative_regulation (inhibits) of GlyRs
1) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0 Pain Relevance 0.05
Since the levels of estrogen fluctuate in both males and females during brain development [31], E2-induced inhibition of GlyRs may contribute to the modulation of estrogen on the early CNS development.
Negative_regulation (inhibition) of GlyRs in brain
2) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0.31 Pain Relevance 0.35
The SF-36 and the GARS appear to be preferable for use in polytrauma patients over the SIP-136.


Negative_regulation (preferable) of GARS
3) Confidence 0.07 Published 2010 Journal J Trauma Manag Outcomes Section Body Doc Link PMC2909985 Disease Relevance 0 Pain Relevance 0
Although the homomeric alpha1 GlyR is equally sensitive to both compounds, we show here that homomeric alpha2 and alpha3 GlyRs, like most GABA(A)Rs, are selectively inhibited by PTXININ.
Negative_regulation (inhibited) of GlyRs associated with gaba
4) Confidence 0.05 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17714449 Disease Relevance 0 Pain Relevance 0.20
We conclude that cannabinoid agonists may be useful as pharmacological tools for selectively inhibiting alpha2 and alpha3 GlyRs.
Negative_regulation (inhibiting) of GlyRs associated with cannabinoid and agonist
5) Confidence 0.05 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18755158 Disease Relevance 0 Pain Relevance 0.56
These results define the orientation of PTXININ and PTN binding in the alpha1 GlyR pore and allow us to conclude that the relatively reduced sensitivity of PTN at GABA(A)Rs and alpha2 and alpha3 GlyRs is due predominantly to its larger size and reduced ability to form hydrophobic interactions with 2' alanines.
Negative_regulation (reduced) of GlyRs in pore associated with gaba
6) Confidence 0.03 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17714449 Disease Relevance 0 Pain Relevance 0.18

General Comments

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