INT14600

Context Info Confidence 0.68 First Reported 1990 Last Reported 2010 Negated 10 Speculated 2 Reported most in Abstract Documents 51 Total Number 53 Disease Relevance 22.10 Pain Relevance 7.70

peptidase activity (Tpsab1) extracellular region (Tpsab1)

Anatomy Link Frequency mast cell 16 urine 5 microglial cells 2 skin 2 synovial fluid 1 Tpsab1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Nerve growth factor 24 99.92 Opioid 1 99.52 aspirin 3 99.50 interstitial cystitis 34 99.48 adenocard 4 99.00 addiction 1 98.96 Codeine 5 98.76 psoriasis 1 98.60 chemokine 2 98.56 spastic colon 34 98.32

Disease Link Frequency Relevance Heat Mastocytosis 14 100.00 Myocardial Infarction 7 99.88 Gastroenteritis 1 99.88 Anaphylaxis 67 99.72 Cancer 12 99.58 Rhinitis 1 99.56 Psoriasis 2 99.54 Interstitial Cystitis 34 99.48 Hemorrhage 1 99.42 Pancytopenia 1 99.22

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Recently, methylhistamine, the major metabolite of histamine, and the specific mast cell marker, tryptase, were shown to be significantly elevated in urine of interstitial cystitis patients.

Positive_regulation (elevated) of tryptase in mast cell associated with interstitial cystitis

1) Confidence 0.68 Published 1995 Journal J. Urol. Section Abstract Doc Link 7861501 Disease Relevance 1.26 Pain Relevance 0.80

However, the tryptase levels in 24 h urine samples were greatly elevated only in patients with IC, both before (P < 0.005), and especially after NaCl treatment and dialysis (P < 0.001).

Positive_regulation (elevated) of tryptase in urine

2) Confidence 0.66 Published 1995 Journal Br J Urol Section Body Doc Link 7648070 Disease Relevance 0.13 Pain Relevance 0

The other patient with similar symptoms showed no increase in the level of tryptase, nor any specific IgE to thiopentone or suxamethonium.

Neg (no) Positive_regulation (increase) of tryptase

3) Confidence 0.65 Published 1991 Journal Agents Actions Section Abstract Doc Link 1897443 Disease Relevance 0.26 Pain Relevance 0

One of the patients showed a highly elevated serum level of tryptase reaching 26 micrograms/l 30 min after the initial reaction.

Positive_regulation (elevated) of tryptase

4) Confidence 0.65 Published 1991 Journal Agents Actions Section Abstract Doc Link 1897443 Disease Relevance 0.28 Pain Relevance 0

The increased tryptase concentrations indicate that death was preceded by systemic mast-cell degranulation.

Positive_regulation (increased) of tryptase associated with death

5) Confidence 0.63 Published 1997 Journal Allergy Section Abstract Doc Link 9298181 Disease Relevance 0.25 Pain Relevance 0.17

Tryptase concentrations were increased in only 50% of these patients.

Positive_regulation (increased) of Tryptase

6) Confidence 0.60 Published 2008 Journal Acta Anaesthesiol Scand Section Body Doc Link 18005384 Disease Relevance 0.06 Pain Relevance 0

Mucosal content of tryptase was increased in IBS and mast cells spontaneously released more tryptase (3.22 +/- 3.48 pmol/min/mg vs. 0.87 +/- 0.65 pmol/min/mg, respectively; P = 0.015) and histamine (339.7 +/- 59.0 ng/g vs. 169.3 +/- 130.6 ng/g, respectively; P = 0.015).

Positive_regulation (increased) of tryptase in mast cells

7) Confidence 0.57 Published 2004 Journal Gastroenterology Section Body Doc Link 14988823 Disease Relevance 0.07 Pain Relevance 0

Tryptase levels are not increased during vancomycin-induced anaphylactoid reactions.

Neg (not) Positive_regulation (increased) of Tryptase

8) Confidence 0.56 Published 1998 Journal Anesthesiology Section Title Doc Link 9743397 Disease Relevance 0.27 Pain Relevance 0.16

CONCLUSION: Plasma tryptase levels were not significantly elevated in confirmed anaphylactoid reactions, so they can be used to distinguish chemical from immunologic reactions.

Neg (not) Positive_regulation (elevated) of tryptase in Plasma

9) Confidence 0.49 Published 1998 Journal Anesthesiology Section Body Doc Link 9743397 Disease Relevance 0 Pain Relevance 0

CONCLUSION: Serum levels of tryptase are not elevated in patients with acute coronary syndromes.

Neg (not) Positive_regulation (elevated) of tryptase

10) Confidence 0.48 Published 2001 Journal Int. J. Cardiol. Section Body Doc Link 11259815 Disease Relevance 0.06 Pain Relevance 0

Increased tryptase concentration in serum is a marker for systemic mast cell activation.

Positive_regulation (Increased) of tryptase in mast cell

11) Confidence 0.46 Published 2006 Journal Lijec Vjesn Section Abstract Doc Link 17128671 Disease Relevance 0.87 Pain Relevance 0.26

Nine observations were itemized (0.047%): 3 generalized erythema observations (grade I), in which atracurium was incriminated twice, and propacetamol once; 2 observations of grade II, in which vecuronium (elevated tryptase) and atracurium were incriminated; 4 anaphylactic shocks, in which three neuromuscular blocking drugs (suxamethonium, vecuronium and pancuronium), and one antibiotic (cloxacilline) were incriminated.

Positive_regulation (elevated) of tryptase associated with erythema, anaphylaxis and shock

12) Confidence 0.46 Published 1998 Journal Allerg Immunol (Paris) Section Abstract Doc Link 9657022 Disease Relevance 0.60 Pain Relevance 0

Elevated mast cell tryptase in the urine of patients with interstitial cystitis.

Positive_regulation (Elevated) of tryptase in urine associated with interstitial cystitis

13) Confidence 0.45 Published 1995 Journal Br J Urol Section Title Doc Link 7648070 Disease Relevance 0.19 Pain Relevance 0.28

In 32%, the concentration of tryptase was elevated (> or = 10 micrograms/l), and the mean value of tryptase was significantly different from a control group dying from known, nonimmunologic causes (P < 0.05).

Positive_regulation (elevated) of tryptase

14) Confidence 0.42 Published 1997 Journal Allergy Section Abstract Doc Link 9298181 Disease Relevance 0.23 Pain Relevance 0.14

HYPOTHESIS: Acute coronary events (acute myocardial infarction and unstable angina pectoris) are associated with increased mast cell activity, reflected by elevated serum tryptase levels.

Positive_regulation (elevated) of tryptase in mast cell

15) Confidence 0.42 Published 2001 Journal Int. J. Cardiol. Section Body Doc Link 11259815 Disease Relevance 0.09 Pain Relevance 0

Changes in tryptase (at peak histamine and 10 min after vancomycin infusion), histamine levels, and histamine-mediated symptoms were assessed using Fisher's exact test, the Student's t test, or the paired t test, as appropriate.

Positive_regulation (Changes) of tryptase

16) Confidence 0.41 Published 1998 Journal Anesthesiology Section Body Doc Link 9743397 Disease Relevance 0 Pain Relevance 0

Application to the measurement of serum tryptase].

Positive_regulation (measurement) of tryptase

17) Confidence 0.40 Published 1997 Journal Allerg Immunol (Paris) Section Title Doc Link 9453735 Disease Relevance 0.53 Pain Relevance 0.11

The mast cell tryptase was also significantly elevated at 76 microg/L, (Normal 2-14 microg/L).

Positive_regulation (elevated) of tryptase in mast cell

18) Confidence 0.40 Published 2009 Journal Am J Forensic Med Pathol Section Abstract Doc Link 19465816 Disease Relevance 0.95 Pain Relevance 0.48

There was a significant difference in the incidence of positive intradermal tests, radioimmunoassay tests and evidence of an IgE-mediated reaction in patients whose mast cell tryptase concentrations were increased.

Positive_regulation (increased) of tryptase in mast cell

19) Confidence 0.36 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9505773 Disease Relevance 0.21 Pain Relevance 0

Seven of 143 patients whose mast cell tryptase concentrations were not increased at appropriate sampling times had positive tests for IgE antibodies, and in 33 of 158 patients with increased mast cell tryptase concentrations no IgE antibodies were detected.

Positive_regulation (increased) of tryptase in mast cell

20) Confidence 0.36 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9505773 Disease Relevance 0.21 Pain Relevance 0

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