INT146043

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 39
Total Number 40
Disease Relevance 29.93
Pain Relevance 6.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adipoq) extracellular region (Adipoq) endoplasmic reticulum (Adipoq)
Anatomy Link Frequency
adipocytes 15
fat 6
plasma 4
macrophage 2
endothelium 2
Adipoq (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 256 99.08 Very High Very High Very High
fibrosis 293 98.66 Very High Very High Very High
Cannabinoid receptor 62 98.34 Very High Very High Very High
qutenza 29 97.76 Very High Very High Very High
Inflammation 841 96.72 Very High Very High Very High
Cannabinoid 7 94.24 High High
antagonist 8 92.20 High High
cytokine 99 91.84 High High
tolerance 147 90.56 High High
anesthesia 31 89.60 High High
Disease Link Frequency Relevance Heat
Obesity 2209 100.00 Very High Very High Very High
Diabetes Mellitus 531 99.84 Very High Very High Very High
Increased Venous Pressure Under Development 57 99.84 Very High Very High Very High
Syndrome 23 99.82 Very High Very High Very High
Insulin Resistance 253 99.00 Very High Very High Very High
Cardiovascular Disease 131 98.84 Very High Very High Very High
Coronary Heart Disease 143 98.72 Very High Very High Very High
Necrosis 21 98.72 Very High Very High Very High
Cardiovascular Disorder Under Development 224 98.66 Very High Very High Very High
Cancer 57 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To develop new adiponectin inducers, eight species of ferulic esters and amides, and five related compounds were synthesized and tested on the stimulation of adiponectin production in mouse 3T3-L1 and normal human preadipocytes.
Positive_regulation (stimulation) of Gene_expression (production) of adiponectin in 3T3-L1
1) Confidence 0.67 Published 2008 Journal Life Sci. Section Abstract Doc Link 18166202 Disease Relevance 0.09 Pain Relevance 0.13
Treatment with thiazolidinediones increases the expression and secretion of adiponectin in both rodents and humans [15,16], indicating that changes in this adipokine may be integral to the therapeutic effects of thiazolidinediones [17,18].
Positive_regulation (increases) of Gene_expression (expression) of adiponectin
2) Confidence 0.63 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 1.05 Pain Relevance 0.06
These results suggest that the present ferulamides would be useful lead compounds in developing more potent agents for treatment of metabolic syndromes through promoting the endogenous adiponectin production, and that such an activity is possibly enhanced by the coadministration with DHA.
Positive_regulation (promoting) of Gene_expression (production) of adiponectin associated with syndrome
3) Confidence 0.59 Published 2008 Journal Life Sci. Section Abstract Doc Link 18166202 Disease Relevance 0.10 Pain Relevance 0.13
The adiponectin production by 7 is synergistically enhanced by coaddition of a PPARgamma-specific agonist, pioglitazone (PGZ), or another PPARgamma agonist, docosahexaenoic acid (DHA), in cultured preadipocytes.
Positive_regulation (enhanced) of Gene_expression (production) of adiponectin associated with agonist
4) Confidence 0.59 Published 2008 Journal Life Sci. Section Abstract Doc Link 18166202 Disease Relevance 0.07 Pain Relevance 0.21
Adiponectin overexpression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Adiponectin
5) Confidence 0.51 Published 2008 Journal Diabetes Section Body Doc Link PMC2518499 Disease Relevance 0.15 Pain Relevance 0.17
Importantly, adiponectin expression was significantly increased in adipocytes from IR?
Positive_regulation (increased) of Gene_expression (expression) of adiponectin in adipocytes associated with obesity
6) Confidence 0.45 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.13 Pain Relevance 0.21
HSD1 -/- mice have higher expression of uncoupling protein 2 (UCP-2) when fed high fat diet and this might be due to the elevated expression in adiponectin [5].
Spec (might) Positive_regulation (due) of Gene_expression (expression) of adiponectin in fat
7) Confidence 0.42 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.71 Pain Relevance 0
HSD1 activity in adipocytes is able to increase adiponectin production, suggesting that the effect seen in intact mice is a direct one on the adipose mass.


Positive_regulation (increase) of Gene_expression (production) of adiponectin in adipocytes associated with obesity
8) Confidence 0.42 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.49 Pain Relevance 0.08
HSD1 -/- mice have higher expression of uncoupling protein 2 (UCP-2) when fed high fat diet and this might be due to the elevated expression in adiponectin [5].
Positive_regulation (elevated) of Gene_expression (expression) of adiponectin in fat
9) Confidence 0.42 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.71 Pain Relevance 0
This model displayed increased expression of adiponectin in subcutaneous adipose tissue, when fed a high fat diet compared with wild type [21].
Positive_regulation (increased) of Gene_expression (expression) of adiponectin in fat associated with obesity
10) Confidence 0.42 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 1.02 Pain Relevance 0.09
Effects of BOF and DAI on mRNA expression of adiponectin and its plasma levels
Positive_regulation (levels) of Gene_expression (expression) of adiponectin in plasma
11) Confidence 0.39 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.27 Pain Relevance 0
Consistently with these findings, adiponectin mRNA expression and adiponectin serum levels were elevated in ?
Positive_regulation (elevated) of Gene_expression (expression) of adiponectin
12) Confidence 0.39 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0 Pain Relevance 0
We hypothesized that the antifibrotic effect of pioglitazone on AngII-induced cardiac fibrosis could be mediated through increases in plasma adiponectin because adiponectin overexpression has been reported to attenuate cardiac hypertrophy in mice (30) and because pioglitazone treatment increased plasma adiponectin threefold in AngII-infused cPPAR??
Positive_regulation (overexpression) of Gene_expression (overexpression) of adiponectin in plasma associated with fibrosis, coronary heart disease and cardiovascular disorder under development
13) Confidence 0.34 Published 2008 Journal Diabetes Section Body Doc Link PMC2518499 Disease Relevance 0.83 Pain Relevance 0.25
–independent effects of pioglitazone: increased adiponectin expression and attenuation of proinflammatory macrophage activity.
Positive_regulation (increased) of Gene_expression (expression) of adiponectin in macrophage
14) Confidence 0.34 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2518499 Disease Relevance 1.07 Pain Relevance 0.38
Capsaicin inhibited the expressions of IL-6 and MCP-1 mRNAs and protein release from the adipose tissues and adipocytes of obese mice, whereas it enhanced the expression of the adiponectin gene and protein.
Positive_regulation (enhanced) of Gene_expression (expression) of adiponectin gene in adipocytes associated with qutenza and obesity
15) Confidence 0.33 Published 2007 Journal FEBS Lett. Section Abstract Doc Link 17719033 Disease Relevance 1.19 Pain Relevance 0.68
Importantly, adiponectin expression was significantly increased in adipocytes from IR?
Positive_regulation (increased) of Gene_expression (expression) of adiponectin in adipocytes associated with obesity
16) Confidence 0.33 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.13 Pain Relevance 0.21
Adenovirus expressing mouse adiponectin (Ad-APN) was generated from the full-length cDNA (26), subcloned with an Adenovirus Expression Vector Kit (Takara Biomedical), propagated in HEK293 cells, and purified and quantified with BD Adeno-X Virus Purification and Rapid Titer kits (BD Biosciences).
Positive_regulation (generated) of Gene_expression (expressing) of Ad-APN
17) Confidence 0.30 Published 2008 Journal Diabetes Section Body Doc Link PMC2518499 Disease Relevance 0.15 Pain Relevance 0.16
Consistently with these findings, adiponectin mRNA expression and adiponectin serum levels were elevated in ?
Positive_regulation (elevated) of Gene_expression (expression) of adiponectin mRNA
18) Confidence 0.28 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0 Pain Relevance 0
In addition, our laboratory has demonstrated the anti-diabetic effect of two natural compounds from Radix Astragali, astragaloside II and isoastragaloside I, which can enhance the expression of adiponectin, an insulin-sensitizing adipokine [17].
Positive_regulation (enhance) of Gene_expression (expression) of adiponectin associated with diabetes mellitus
19) Confidence 0.28 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 1.14 Pain Relevance 0.26
Hematological variables according to adiponectin genotype
Positive_regulation (according) of Gene_expression (variables) of adiponectin genotype
20) Confidence 0.27 Published 2007 Journal Nutrition Research and Practice Section Body Doc Link PMC2849047 Disease Relevance 0.84 Pain Relevance 0.03

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