INT146054

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.00
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr68) plasma membrane (Gpr68) signal transducer activity (Gpr68)
Gpr68 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 51 99.72 Very High Very High Very High
Pain 19 93.48 High High
nociceptor 10 92.88 High High
vanilloid receptor subtype 1 2 90.72 High High
IPN 28 90.08 High High
tissue acidosis 3 83.32 Quite High
dorsal root ganglion 5 82.72 Quite High
ischemia 1 81.36 Quite High
chemokine 1 62.76 Quite High
Hyperalgesia 23 47.24 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 52 99.72 Very High Very High Very High
Pain 21 93.48 High High
Acidosis 4 93.00 High High
Inflammatory Pain 28 90.08 High High
Ganglion Cysts 5 81.76 Quite High
Cv Unclassified Under Development 1 81.36 Quite High
Injury 2 80.24 Quite High
Adhesions 1 79.44 Quite High
Congenital Anomalies 1 73.84 Quite High
Nociception 11 64.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Proton-sensing GPCRs, including OGR1, GPR4, G2A, and TDAG8, are fully activated at pH 6.4-6.8 in vitro.
Positive_regulation (activated) of OGR1
1) Confidence 0.57 Published 2007 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 17720533 Disease Relevance 1.27 Pain Relevance 0.99
However, OGR1 protein and function could still be enhanced after inflammation despite no change in mRNA expression.
Neg (no) Positive_regulation (enhanced) of OGR1 protein associated with inflammation
2) Confidence 0.29 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.73 Pain Relevance 0.45

General Comments

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