INT146055

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Context Info
Confidence 0.63
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 10
Disease Relevance 8.12
Pain Relevance 6.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr68) plasma membrane (Gpr68) signal transducer activity (Gpr68)
Anatomy Link Frequency
neuronal 1
neurons 1
nociceptors 1
Gpr68 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 59 99.98 Very High Very High Very High
dorsal root ganglion 5 99.72 Very High Very High Very High
Inflammation 412 99.44 Very High Very High Very High
IPN 225 99.08 Very High Very High Very High
qutenza 352 98.24 Very High Very High Very High
Pain 117 97.92 Very High Very High Very High
Hyperalgesia 184 96.48 Very High Very High Very High
Lasting pain 16 92.60 High High
Neuropathic pain 8 89.88 High High
carrageenan induced 16 85.04 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 5 99.72 Very High Very High Very High
INFLAMMATION 430 99.44 Very High Very High Very High
Inflammatory Pain 225 99.08 Very High Very High Very High
Nociception 74 98.52 Very High Very High Very High
Pain 133 97.92 Very High Very High Very High
Hyperalgesia 216 96.48 Very High Very High Very High
Adhesions 9 92.64 High High
Pressure And Volume Under Development 168 91.92 High High
Neuropathic Pain 8 89.88 High High
Congenital Anomalies 8 87.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The OGR1 family members were widely expressed in neuronal and non-neuronal tissues.
Gene_expression (expressed) of OGR1 in neuronal
1) Confidence 0.63 Published 2007 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 17720533 Disease Relevance 1.36 Pain Relevance 0.96
Examples of these include Ccr2, Gpr84 and Fprl1 that were selectively enriched in BMM as compared to TEPM and RAW264, whilst Gpr68 was enriched in both TEPM and RAW264 but not BMM.
Neg (not) Gene_expression (enriched) of Gpr68
2) Confidence 0.56 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.11 Pain Relevance 0.06
The OGR1 family were expressed differently in these three inflammatory pain models.
Gene_expression (expressed) of OGR1 associated with ipn
3) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 1.47 Pain Relevance 1.56
Saline injection produced no increase or decrease in OGR1 family gene expression (Fig. 2D).


Gene_expression (expression) of OGR1
4) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.87 Pain Relevance 0.60
Here, we demonstrated that OGR1 family subtypes are expressed differently in different inflammatory pain states, which suggests that they are involved in neurogenic, short-term and long-term chronic inflammatory pain.
Gene_expression (expressed) of OGR1 associated with ipn
5) Confidence 0.45 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.43 Pain Relevance 0.49
OGR1 is the only receptor whose expression did not change in any inflammatory pain models we tested.
Gene_expression (expression) of OGR1 associated with ipn
6) Confidence 0.39 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 1.10 Pain Relevance 0.62
In this study, we used the inflammatory agents capsaicin, carrageenan, or complete Freund's adjuvant (CFA) to induce peripheral inflammation and examined the change in expression of OGR1 family genes in DRG neurons.
Gene_expression (expression) of OGR1 in neurons associated with qutenza and inflammation
7) Confidence 0.35 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 1.08 Pain Relevance 0.97
Each subtype of the OGR1 family was expressed differently, which may reflect differences between models in duration and magnitude of hyperalgesia.
Gene_expression (expressed) of OGR1 associated with hyperalgesia
8) Confidence 0.35 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.59 Pain Relevance 0.67
About 31%~40% nociceptors express at least two OGR1 family genes [28].
Gene_expression (express) of OGR1 in nociceptors associated with nociceptor
9) Confidence 0.35 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.18 Pain Relevance 0.27
Each subtype of the OGR1 family was expressed differently, which may reflect differences between models in duration and magnitude of hyperalgesia.
Gene_expression (expressed) of OGR1 associated with hyperalgesia
10) Confidence 0.35 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2716309 Disease Relevance 0.93 Pain Relevance 0.80

General Comments

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