INT146057

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Context Info
Confidence 0.60
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.26
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpr4) plasma membrane (Gpr4) signal transducer activity (Gpr4)
Gpr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 19 93.24 High High
qutenza 44 93.04 High High
nociceptor 10 92.88 High High
vanilloid receptor subtype 1 2 90.48 High High
Hyperalgesia 23 83.36 Quite High
tissue acidosis 3 83.08 Quite High
dorsal root ganglion 5 82.72 Quite High
ischemia 1 81.12 Quite High
Inflammation 51 80.56 Quite High
IPN 28 47.96 Quite Low
Disease Link Frequency Relevance Heat
Pain 21 93.24 High High
Acidosis 4 92.76 High High
Pressure And Volume Under Development 21 84.16 Quite High
Hyperalgesia 27 83.36 Quite High
Ganglion Cysts 5 81.76 Quite High
Cv Unclassified Under Development 1 81.12 Quite High
INFLAMMATION 52 80.56 Quite High
Injury 2 80.00 Quite High
Death 1 74.12 Quite High
Apoptosis 1 70.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Proton-sensing GPCRs, including OGR1, GPR4, G2A, and TDAG8, are fully activated at pH 6.4-6.8 in vitro.
Positive_regulation (activated) of GPR4
1) Confidence 0.60 Published 2007 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 17720533 Disease Relevance 1.27 Pain Relevance 0.98
GPR4, G2A, and TDAG8 transcripts were increased in levels 24 hours after carrageenan injection, but only TDAG8 expression was increased after CFA injection.
Positive_regulation (increased) of GPR4
2) Confidence 0.51 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.99 Pain Relevance 0.96

General Comments

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