INT146088

Context Info Confidence 0.49 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.09 Pain Relevance 0.34

transport (Abcb1b, Abcb1a) ATPase activity (Abcb1b, Abcb1a) transmembrane transport (Abcb1b, Abcb1a) mitochondrion (Abcb1b) plasma membrane (Abcb1a)

Abcb1b (Mus musculus) Abcb1a (Mus musculus)

Pain Link Frequency Relevance Heat fluoxetine 8 99.46

Disease Link Frequency Relevance Heat Drug Induced Neurotoxicity 3 94.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The purpose of this investigation is to evaluate the pharmacokinetic drug interaction between MDMA and fluoxetine and also to determine the role of P-glycoprotein (P-gp) on mediating drug-drug interactions with MDMA.

P-glycoprotein Regulation (role) of P-gp associated with fluoxetine

1) Confidence 0.49 Published 2008 Journal J Pharm Sci Section Abstract Doc Link 17724664 Disease Relevance 0.09 Pain Relevance 0.34

General Comments

This test has worked.