INT146091

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 9.12
Pain Relevance 4.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (IFNAR1)
Anatomy Link Frequency
arm 1
leg 1
frontal cortex 1
IFNAR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal-cord stimulation 46 99.82 Very High Very High Very High
analgesia 17 98.12 Very High Very High Very High
Pain refractory 2 96.96 Very High Very High Very High
reflex sympathetic dystrophy 12 96.92 Very High Very High Very High
rheumatoid arthritis 56 96.64 Very High Very High Very High
lidocaine 24 96.40 Very High Very High Very High
Pain 224 96.16 Very High Very High Very High
Clonidine 20 95.84 Very High Very High Very High
balanced analgesia 8 91.96 High High
cINOD 16 89.92 High High
Disease Link Frequency Relevance Heat
Complex Regional Pain Syndromes 622 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 48 100.00 Very High Very High Very High
Li-fraumeni Syndrome 8 99.96 Very High Very High Very High
Urological Neuroanatomy 1 97.92 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

1 97.42 Very High Very High Very High
Intractable Pain 2 96.96 Very High Very High Very High
Rheumatoid Arthritis 56 96.64 Very High Very High Very High
Pain 216 96.16 Very High Very High Very High
Cognitive Disorder 13 95.52 Very High Very High Very High
Recurrence 56 94.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adequate perioperative analgesia, limitation of operating time, limited use of tourniquet, and use of regional anaesthetic techniques are recommended for secondary prevention of CRPS-I.
Negative_regulation (prevention) of CRPS-I associated with complex regional pain syndromes and analgesia
1) Confidence 0.25 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2861029 Disease Relevance 0.74 Pain Relevance 0.54
Adequate perioperative analgesia, limitation of operating time, limited use of tourniquet, and use of regional anaesthetic techniques are recommended for secondary prevention of CRPS-I.


Negative_regulation (prevention) of CRPS-I associated with complex regional pain syndromes and analgesia
2) Confidence 0.18 Published 2010 Journal BMC Neurol Section Abstract Doc Link PMC2861029 Disease Relevance 0.74 Pain Relevance 0.56
Prevention of CRPS-I
Negative_regulation (Prevention) of CRPS-I associated with complex regional pain syndromes
3) Confidence 0.18 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2861029 Disease Relevance 0.83 Pain Relevance 0.17
In a randomized double-blind study in 84 patients with a history of CRPS-I in the hand or arm scheduled for hand or arm surgery, intravenous regional blockade with lidocaine and clonidine (1 ?
Negative_regulation (history) of CRPS-I in arm associated with complex regional pain syndromes, lidocaine and clonidine
4) Confidence 0.18 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2861029 Disease Relevance 1.21 Pain Relevance 0.79
Adequate perioperative analgesia, limitation of operation time and limited use of bloodlessness are advised for the secondary prevention of CRPS-I.
Negative_regulation (prevention) of CRPS-I associated with complex regional pain syndromes and analgesia
5) Confidence 0.08 Published 2007 Journal Ned Tijdschr Geneeskd Section Abstract Doc Link 17725255 Disease Relevance 0.71 Pain Relevance 0.51
She had received lumbar SCS under a diagnosis of CRPS-I in her left leg for 8 years.
Negative_regulation (diagnosis) of CRPS-I in leg associated with complex regional pain syndromes and spinal-cord stimulation
6) Confidence 0.05 Published 2009 Journal Masui Section Abstract Doc Link 19764441 Disease Relevance 0.86 Pain Relevance 0.73
After the conditioning LFS, VRS-I, VRS-U, SES-S, and SES-A decreased as compared to Pre series and Control.
Negative_regulation (decreased) of VRS-I associated with li-fraumeni syndrome
7) Confidence 0.02 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19604709 Disease Relevance 1.97 Pain Relevance 1.09
Studies in human postmortem brain have previously demonstrated a general decrease in calcium/cAMP-related signaling transcripts in frontal and motor cortex of human alcoholics [13], a decrease in adenylate cyclase (AC) type I (AC-I) protein levels and activity in temporal and frontal cortex in alcoholics [22]–[23] and in AC-I mRNA and protein in temporal cortex from heroin addicts [24].
Negative_regulation (decrease) of ) type I in frontal cortex associated with urological neuroanatomy
8) Confidence 0.01 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.53 Pain Relevance 0.18
In addition, ERA patients exhibited a mild dyslipidemia characterized by an increase in the serum levels of total cholesterol, LDL-cholesterol, triglycerides and Apo B as well as by a decrease in the serum levels of HDL-cholesterol and Apo A-I compared with controls.
Negative_regulation (decrease) of A-I associated with rheumatoid arthritis and disorder of lipid metabolism
9) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860077 Disease Relevance 1.42 Pain Relevance 0.30

General Comments

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