INT146107

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.91
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lrp1) endosome (Lrp1) plasma membrane (Lrp1)
nucleus (Lrp1) cytoplasm (Lrp1)
Anatomy Link Frequency
neurons 1
peripheral nerve 1
Lrp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Peripheral nerve injury 3 99.58 Very High Very High Very High
Eae 4 93.68 High High
Inflammation 26 78.36 Quite High
Sciatic nerve 1 76.72 Quite High
cytokine 18 67.64 Quite High
Central nervous system 14 51.52 Quite High
Hippocampus 11 49.60 Quite Low
Thalamus 1 47.36 Quite Low
Neuropathic pain 2 44.52 Quite Low
Dysuria 2 36.52 Quite Low
Disease Link Frequency Relevance Heat
Nervous System Injury 5 99.58 Very High Very High Very High
Disorder Of Lipid Metabolism 8 98.32 Very High Very High Very High
Injury 3 93.68 High High
Disease 139 92.96 High High
Targeted Disruption 13 80.60 Quite High
INFLAMMATION 28 78.36 Quite High
Contracture 33 76.88 Quite High
Death 11 73.12 Quite High
Urinary Calculi 9 72.32 Quite High
Toxicity 5 65.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antagonizing the extracellular interaction between cell-surface APP and LRP increased the level of cell surface APP while decreasing A?
Positive_regulation (surface) of LRP
1) Confidence 0.37 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.52 Pain Relevance 0
These studies demonstrate that an alpha2M derivative is capable of regulating the response to peripheral nerve injury by a mechanism that requires low-density lipoprotein receptor-related protein-1.
Positive_regulation (requires) of receptor-related protein-1 in peripheral nerve associated with nervous system injury and peripheral nerve injury
2) Confidence 0.20 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17725582 Disease Relevance 0.86 Pain Relevance 0.32
After cholesterol is synthesised in astrocytes, it is released through ABCA1 and packaged into lipoprotein particles resembling HDL, which in turn are then taken up into neurons through the recognition of ApoE by a variety of lipoprotein receptors such as LDLR, LRP and the ApoE receptor.
Positive_regulation (variety) of LRP in neurons associated with disorder of lipid metabolism
3) Confidence 0.12 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.10 Pain Relevance 0.03
Of the 641 patients, 439, 49, and 153 underwent RRP, LRP, and RALP, respectively.
Positive_regulation (underwent) of LRP
4) Confidence 0.05 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2963780 Disease Relevance 0.44 Pain Relevance 0

General Comments

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