INT146109

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.73
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serping1) extracellular region (Serping1)
Anatomy Link Frequency
plasma 1
head 1
Serping1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 18 99.96 Very High Very High Very High
Peripheral nerve injury 3 97.60 Very High Very High Very High
Inflammation 159 94.88 High High
Neuropathic pain 1 87.48 High High
long-term potentiation 1 73.92 Quite High
Glutamate receptor 1 72.00 Quite High
Sciatic nerve 1 55.16 Quite High
Eae 2 47.68 Quite Low
Hippocampus 19 24.00 Low Low
Central nervous system 24 16.52 Low Low
Disease Link Frequency Relevance Heat
Head Trauma 1 99.02 Very High Very High Very High
Repression 4 98.26 Very High Very High Very High
Nervous System Injury 5 97.16 Very High Very High Very High
INFLAMMATION 170 94.88 High High
Death 27 94.40 High High
Brain Injury 44 94.04 High High
Apoptosis 8 94.00 High High
Neuropathic Pain 1 87.48 High High
Schizophrenia 7 81.76 Quite High
Disease 27 76.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The regulation of complement appears to be balanced as the slp increase suggests the need for immune complex clearance concomitant with a Serping1 increase, inhibiting complement activation via the classical pathway.
Positive_regulation (increase) of Serping1
1) Confidence 0.59 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.58 Pain Relevance 0.10
After head trauma, the mAb1379-injected mice showed a significant upregulation of the protective Bcl-2 and C1-Inh genes for up to 7 days, as compared to placebo-injected or sham-operated mice (P < 0.05, unpaired Student's t-test; n = 6 per gene, time-point, and TBI group Fig. 7).
Positive_regulation (upregulation) of C1-Inh in head associated with head trauma and brain injury
2) Confidence 0.27 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1867808 Disease Relevance 1.03 Pain Relevance 0
Because LPS-gene profiling indicated repression of the complement classical pathway [C1qa, C1qb and C1qc downregulation and Serping1 (C1-Inhibitor) upregulation], we further characterized the temporal dynamic of this process (Figure S2).
Positive_regulation (upregulation) of C1-Inhibitor associated with repression
3) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.10 Pain Relevance 0
A derivative of the plasma protease inhibitor alpha(2)-macroglobulin regulates the response to peripheral nerve injury.
Positive_regulation (derivative) of plasma protease in plasma associated with nervous system injury, cytokine and peripheral nerve injury
4) Confidence 0.06 Published 2007 Journal J. Neurochem. Section Title Doc Link 17725582 Disease Relevance 1.02 Pain Relevance 0.58

General Comments

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