INT146112

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.19
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b, Tnf) extracellular region (Il1b, Tnf) cell proliferation (Tnf)
signal transduction (Tnf) aging (Il1b) plasma membrane (Tnf)
Il1b (Mus musculus)
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 5 98.30 Very High Very High Very High
Neuropathic pain 1 83.64 Quite High
Inflammation 4 81.76 Quite High
Peripheral nerve injury 3 75.00 Quite High
Sciatic nerve 1 74.72 Quite High
Eae 2 59.76 Quite High
Disease Link Frequency Relevance Heat
Necrosis 1 100.00 Very High Very High Very High
Cancer 1 100.00 Very High Very High Very High
Toxicity 1 98.56 Very High Very High Very High
Neuropathic Pain 1 83.64 Quite High
Nervous System Injury 5 82.80 Quite High
INFLAMMATION 4 81.76 Quite High
Death 1 81.28 Quite High
Injury 3 73.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously, we generated an alpha2M derivative (alpha(2)-macroglobulin activated for cytokine binding; MAC) similar in structure to alpha(2)M conformational intermediates, which binds tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and inhibits endotoxin toxicity.
interleukin-1beta Binding (binds) of TNF-alpha associated with toxicity, necrosis, cancer and cytokine
1) Confidence 0.32 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17725582 Disease Relevance 1.19 Pain Relevance 0.56

General Comments

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