INT146139

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Context Info
Confidence 0.12
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 8.43
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (ETV4) nucleus (ETV4) intracellular (ETV4)
Anatomy Link Frequency
lung 1
ETV4 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 22 96.48 Very High Very High Very High
corticosteroid 4 79.76 Quite High
Inflammation 60 50.60 Quite High
cytokine 26 5.00 Very Low Very Low Very Low
tolerance 16 5.00 Very Low Very Low Very Low
imagery 15 5.00 Very Low Very Low Very Low
cva 13 5.00 Very Low Very Low Very Low
palliative 9 5.00 Very Low Very Low Very Low
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 554 99.84 Very High Very High Very High
Infection 101 99.34 Very High Very High Very High
Pancreatic Cancer 410 98.52 Very High Very High Very High
Idiopathic Pulmonary Fibrosis 9 97.32 Very High Very High Very High
Adenovirus Infection 10 93.32 High High
Toxicity 39 91.96 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 88.44 High High
Disease 109 87.60 High High
Hepatitis 1 86.64 High High
Influenza Virus Infection 2 86.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Viral DNA replication and E1A expression were also assessed by quantitative PCR.
Gene_expression (expression) of E1A
1) Confidence 0.12 Published 2007 Journal J Gene Med Section Body Doc Link 17729237 Disease Relevance 0 Pain Relevance 0
Therefore, to determine the specificity of Ad5MK replication, we used pancreatic cancer cell lines with different levels of midkine expression and then examined E1A expression by Western blotting (Figure 3A).
Spec (examined) Gene_expression (expression) of E1A associated with pancreatic cancer
2) Confidence 0.03 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2529268 Disease Relevance 0.82 Pain Relevance 0
The proteins were subjected to SDS-PAGE and expression of E1A protein was analyzed by Western blotting.
Gene_expression (expression) of E1A
3) Confidence 0.03 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2529268 Disease Relevance 0.46 Pain Relevance 0
In the Suit-2 subcutaneous xenograft model, expression of E1A was detected in Ad5MK-treated tumors, but not in untreated and Ad5GFP-treated tumors.
Gene_expression (expression) of E1A associated with cancer
4) Confidence 0.03 Published 2008 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2529268 Disease Relevance 0.68 Pain Relevance 0
Despite the target selectivity of Ad5MK, weak E1A expression was found in midkine-negative cells after infection with 5 MOI of Ad5MK.
Gene_expression (expression) of E1A associated with infection
5) Confidence 0.03 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2529268 Disease Relevance 0.56 Pain Relevance 0
E1A expression was higher in cell lines with strong midkine expression than in cell lines with weak midkine expression.
Gene_expression (expression) of E1A
6) Confidence 0.03 Published 2008 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2529268 Disease Relevance 0.92 Pain Relevance 0
We prepared recombinant adenovirus type 5 containing the 0.6 kb midkne promoter (Ad5MK) for midkne-regulated expression of E1A[24].
Gene_expression (expression) of E1A
7) Confidence 0.03 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2529268 Disease Relevance 0.26 Pain Relevance 0
RT-PCR analysis for human adenovirus type 5 E1A showed that E1A expression could be detected in the Ad5MK groups (Figure 5A).
Gene_expression (expression) of E1A
8) Confidence 0.03 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2529268 Disease Relevance 0.35 Pain Relevance 0
Since the adenoviral infection cycle is completed within 24 h, E1A expression by infected cells after 48 h reflects viral replication.
Gene_expression (expression) of E1A associated with infection
9) Confidence 0.03 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2529268 Disease Relevance 0.71 Pain Relevance 0
Tumour cells have high levels of free E2F and therefore genes that have E2F responsive elements (E1A, TS, TK, dhfr, E2F itself etc.) should be more highly expressed in tumour cells.
Gene_expression (expressed) of E1A associated with cancer
10) Confidence 0.01 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 1.14 Pain Relevance 0
High E2F levels in tumour cells will also drive viral E1A expression allowing effective tumour cell kill by the virus.
Gene_expression (expression) of E1A associated with cancer
11) Confidence 0.01 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 1.07 Pain Relevance 0
Several studies in adult patients have indicated that the adenovirus gene product E1A could be detected in lung tissues by in situ hybridization in up to 16% of cases of idiopathic pulmonary fibrosis.
Gene_expression (detected) of E1A in lung associated with fibrosis and idiopathic pulmonary fibrosis
12) Confidence 0.01 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2939531 Disease Relevance 1.45 Pain Relevance 0.11

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