INT146179

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 9.39
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (KRT6A)
Anatomy Link Frequency
epidermis 4
keratinocyte 3
sweat glands 2
Lymph node 1
mammary gland 1
KRT6A (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 3 97.68 Very High Very High Very High
Inflammation 96 92.72 High High
Pain 9 77.04 Quite High
medulla 112 51.44 Quite High
Chronic pancreatitis 16 5.00 Very Low Very Low Very Low
Bile 16 5.00 Very Low Very Low Very Low
Potency 16 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 1373 100.00 Very High Very High Very High
Skin Cancer 464 99.84 Very High Very High Very High
Injury 192 99.84 Very High Very High Very High
Targeted Disruption 310 99.62 Very High Very High Very High
Breast Cancer 178 99.52 Very High Very High Very High
Metastasis 257 98.82 Very High Very High Very High
Adenocarcinoma 736 97.64 Very High Very High Very High
Metaplasia 64 97.56 Very High Very High Very High
Wound Healing 64 97.48 Very High Very High Very High
Oral Leukoplakia 16 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Imaging in live mice using the Xenogen IVIS system demonstrated that the K6a-specific siRNA strongly inhibited bicistronic K6a-luciferase gene expression in vivo.
Gene_expression (expression) of K6a associated with imagery
1) Confidence 0.75 Published 2008 Journal J. Invest. Dermatol. Section Abstract Doc Link 17762855 Disease Relevance 0.30 Pain Relevance 0.10
We demonstrated near-complete ablation of endogenous K6a protein expression in two keratinocyte cell lines, HaCaT and NEB-1, by transient transfection of each of the four K6a siRNAs.
Gene_expression (expression) of K6a in keratinocyte
2) Confidence 0.75 Published 2008 Journal J. Invest. Dermatol. Section Abstract Doc Link 17762855 Disease Relevance 0.39 Pain Relevance 0.11
OBJECTIVE: Determine if mTOR inhibitors (rapamycin, temsirolimus or everolimus) are viable drug candidates for treatment of PC and other disorders caused by inappropriate expression of K6a and K6b.
Gene_expression (expression) of K6a
3) Confidence 0.75 Published 2009 Journal J. Dermatol. Sci. Section Body Doc Link 19699613 Disease Relevance 0 Pain Relevance 0
CONCLUSION: Rapamycin selectively blocks K6a expression in human keratinocytes.
Gene_expression (expression) of K6a in keratinocytes
4) Confidence 0.75 Published 2009 Journal J. Dermatol. Sci. Section Body Doc Link 19699613 Disease Relevance 0 Pain Relevance 0
Furthermore, treatment of this HaCaT cell line with siRNAs targeting components of the mTOR pathway altered the levels of K6a expression.
Gene_expression (expression) of K6a
5) Confidence 0.75 Published 2009 Journal J. Dermatol. Sci. Section Body Doc Link 19699613 Disease Relevance 0 Pain Relevance 0
We demonstrated near-complete ablation of endogenous K6a protein expression in two keratinocyte cell lines, HaCaT and NEB-1, by transient transfection of each of the four K6a siRNAs.
Gene_expression (transfection) of K6a in keratinocyte
6) Confidence 0.65 Published 2008 Journal J. Invest. Dermatol. Section Abstract Doc Link 17762855 Disease Relevance 0.37 Pain Relevance 0.11
Notably, the pathologic changes affect those tissues that constitutively express K6a and K16 (see above) but not the interfollicular epidermis.
Neg (not) Gene_expression (express) of K6a in epidermis
7) Confidence 0.44 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.52 Pain Relevance 0.03
K6 and K16 are also consistently expressed in non-keratinizing stratified squamous epithelia (Moll et al. 1982b).
Gene_expression (expressed) of K6
8) Confidence 0.44 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.10 Pain Relevance 0
Using this MAb, plantar epidermis shows extended albeit heterogeneous expression of K6a, while interfollicular epidermis is negative or exhibits only some positive suprabasal cell groups (Demirkesen et al. 1995; Swensson et al. 1998).
Gene_expression (expression) of K6a in epidermis
9) Confidence 0.44 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0 Pain Relevance 0
However, quantitatively, squamous cell carcinomas rather embark on an alternative maturation pathway characterized by abundant expression of K6 and K16 (see above; Fig. 4d).
Gene_expression (expression) of K6 associated with skin cancer
10) Confidence 0.44 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.53 Pain Relevance 0
Lymph node metastasis of a squamous cell carcinoma of the head and neck region, expressing K5 (c; more intensely in the peripheral tumor cell layers) as well as K6 (d; particularly strongly in central tumor cells) as signs of their keratinocyte origin.
Gene_expression (expressing) of K6 in Lymph node associated with cancer, skin cancer and metastasis
11) Confidence 0.39 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.86 Pain Relevance 0
Among tumors, K6 and K16 are typically and strongly expressed in squamous cell carcinomas of different sites (Moll et al. 1982b; Moll 1998), preferentially in inner, maturing layers of the tumor cell nests (Fig. 4d).
Gene_expression (expressed) of K6 associated with cancer and skin cancer
12) Confidence 0.39 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.01 Pain Relevance 0
Non-keratinizing stratified squamous epithelia express K6 uniformly in all suprabasal cell layers.
Gene_expression (express) of K6
13) Confidence 0.39 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.06 Pain Relevance 0
Molecular genetic studies have revealed that in humans three isoforms of K6 exist, K6a, K6b, and K6c, encoded by distinct genes (Rogers et al. 2005; Schweizer et al. 2006).
Gene_expression (exist) of K6a
14) Confidence 0.38 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0 Pain Relevance 0
Another interesting feature of K17 is its inducibility after skin injury: after K6/K16 (see above), K17 is switched on in regenerating and migrating epidermal keratinocytes upon wound healing (Paladini et al. 1996).
Gene_expression (switched) of K6 in skin associated with wound healing and injury
15) Confidence 0.38 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.53 Pain Relevance 0.03
K6/K16: keratins of hyperproliferative keratinocytes inducible in “activated” epidermis
Gene_expression (/) of K6 in epidermis
16) Confidence 0.38 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.37 Pain Relevance 0
Molecular genetic studies have revealed that in humans three isoforms of K6 exist, K6a, K6b, and K6c, encoded by distinct genes (Rogers et al. 2005; Schweizer et al. 2006).
Gene_expression (exist) of K6
17) Confidence 0.38 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0 Pain Relevance 0
The best performance on paraffin sections is displayed by MAb D5/16B4 (Lobeck et al. 1989; Demirkesen et al. 1995) which—although being often regarded as “K5/K6 antibody”—specifically recognizes K5 (Böcker et al. 2002).
Gene_expression (antibody) of K6
18) Confidence 0.33 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.84 Pain Relevance 0
Although low expression of these keratins may be found in adenocarcinomas such as occasionally in adenocarcinomas of the uterine cervix (Smedts et al. 1993) and in less than 20% of invasive breast carcinomas (Wetzels et al. 1991), K6 as detected by MAb KA12 may be suitable—in addition to K5—as another immunohistochemical marker of squamous differentiation in poorly differentiated squamous cell carcinomas (Moll 1998).


Gene_expression (detected) of K6 in uterine cervix associated with adenocarcinoma, breast cancer and skin cancer
19) Confidence 0.33 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.08 Pain Relevance 0
Thus, K6 (most probably K6a) and K16 are expressed in ductal luminal cells as well as in some secretory cells of human eccrine sweat glands (Fig. 5; Demirkesen et al. 1995; Langbein et al. 2005).
Gene_expression (expressed) of K6a in sweat glands
20) Confidence 0.30 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.45 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox